SITC 2017 Abstract Titles – Oncogenetics and Immunogenomics

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DNA Repair Genetic Aberrations and Tumor Mutation Burden in Biliary Tract Cancers

Reham Abdel-Wahab1,2, Rachna Shroff1, Jean Nicolas Vauthey1, Eugene Jon Koay1, Siraj Ali3, Lawrence Kwong1, Mingxin Zuo1, Asif Rashid1, Milind Javle1

1MD Anderson Cancer Center, Houston, TX, USA 2Assiut University Hospital, Assiut Faculty of Medicine, Assiut, Egypt 3Foundation Medicine, Cambridge, MA, USA

Gene expression | Checkpoint blockade


Evolving immune response in lung squamous carcinogenesis

Celine Mascaux1, Mihaela Angelova2, Angela Vasaturo2, Jennifer Beane3, Kahkeshan Hijazi4, Geraldine Anthoine5, Karen Willard-Gallo5, Annick Haller6, Vincent Ninane7, Arsène Burny5, Jean-Paul Sculier8, Avrum Spira9, Jérôme Galon2

1Marseille Early Phases Cancer Trials Center CLIP, Marseille, France 2Laboratory of Integrative Cancer Immunology, Paris, France 3Boston Univ. School of Medicine, Boston, MA, USA 4Research Center for Modeling and Simulation, Islamabad, Pakistan 5Institut Jules Bordet, Université Libre de Bruxelles, Brussels, Belgium 6University Chidren's Hospital Queen Fabiola, Brussels, Belgium 7CHU Saint-Pierre - Service de Pneumologie, Brussels, Belgium 8Institut Jules Bordet, Centre des Tumeurs de l'Université Libre de Bruxelles, Brussels, Belgium 9Boston University Medical Center, Boston, MA, USA

Bioinformatics | Carcinogenesis | Immune contexture | Immune tolerance | Tumor microenvironment | Immunoscore | Tumor infiltrating lymphocytes (TILs) | Gene expression | Tumor evasion | Immune suppression




Tumor Mutation Load Assessment of FFPE samples using an NGS based assay

Ruchi Chaudhary1, Asha Kamat1, Warren Tom1, Iris Casuga1, Dinesh Cyanam2, Dumitru Brinza1, Janice Au-Young1, Fiona Hyland1

1Thermofisher Scientific, South San Francisco, CA, USA 2Thermofisher Scientific, Ann Arbor, MI, USA

Bioinformatics | Biomarkers


Rationally improving T cell-mediated cancer immunotherapy using Sleeping Beauty mutagenesis to identify novel drug targets

Laura Rogers1, Adam Dupuy1, George Weiner1

1University of Iowa, Iowa City, IA, USA

Adoptive immunotherapy | Bioinformatics | T cell | Tumor infiltrating lymphocytes (TILs) | CAR T cells | Checkpoint blockade | Tumor microenvironment


Evaluation of tumor genetics and microenvironment through next-generation sequencing (NGS)

Alex So1, Shannon Kaplan1, Joyee Yao1, Shile Zhang1, Aaron Wise1, Kristina Kruglyak1, Naomi O'Grady1, Jeremiah Mcdole1, Marina Bibikova1

1Illumina, San Diego, CA, USA

T cell | Tumor microenvironment | Checkpoint blockade | Neoantigens | Vaccine | Tumor infiltrating lymphocytes (TILs) | B cell