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A novel TLR4 binding protein, 40S ribosomal protein S3, has potential utility as an adjuvant in a dendritic cell-based vaccine

Published in the Journal for ImmunoTherapy of Cancer (JITC), is a research article in which 40S ribosomal protein S3 (RPS3) was screened through pull-down assay using TLR4. BMDCs from wild type (WT) and TLR4 knock-out mice were treated by RPS3 to identify the activation and maturation of DCs. T...


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Persistent mutant oncogene specific T cells in two patients benefitting from anti-PD-1

Published in the Journal for ImmunoTherapy of Cancer (JITC), is a research article which studied two patients with unexpected responses to checkpoint blockade monotherapy: a patient with PD-L1-negative and low mutational burden NSCLC and one with mismatch repair proficient colorectal cancer (CRC...


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Phase Ib evaluation of a self-adjuvanted protamine formulated mRNA-based active cancer immunotherapy, BI1361849 (CV9202), combined with local radiation treatment in patients with stage IV non-small c

Published in the Journal for ImmunoTherapy of Cancer (JITC), is a research article describing a phase Ib clinical trial evaluating treatment with BI1361849 combined with local radiation in 26 stage IV NSCLC patients with partial response (PR)/stable disease (SD) after standard first-line therapy...


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Two roads for oncolytic immunotherapy development

Published in the Journal for ImmunoTherapy of Cancer (JITC), is an editorial article suggesting that further studies on Oncolytic viruses should include assessment of viral replication in tumor tissue and consider comparative trials using IV and intratumoral delivery to fully optimize oncolytic...


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Demarcated thresholds of tumor-specific CD8 T cells elicited by MCMV-based vaccine vectors provide robust correlates of protection

Published in the Journal for ImmunoTherapy of Cancer (JITC), is a research article highlighting the effectiveness of CMV-based vaccine vectors, and showing that demarcated thresholds of vaccine-specific T cells could be defined that correlate to tumor protection. Together, these results may hold...


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FLT PET/CT imaging of metastatic prostate cancer patients treated with pTVG-HP DNA vaccine and pembrolizumab

Published in the Journal for ImmunoTherapy of Cancer (JITC), is a research article illustrating that FLT PET uptake was significantly predictive of progression-free survival and the occurrence of adverse events relating to thyroid function. The results suggest FLT PET imaging has potential as a...


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A phase 1 dose escalation study of the oncolytic adenovirus enadenotucirev, administered intravenously to patients with epithelial solid tumors (EVOLVE)

Published in the Journal for ImmunoTherapy of Cancer (JITC), is a research article providing key clinical data in patients with solid epithelial tumors following treatment with IV enadenotucirev monotherapy and supports further investigation of enadenotucirev in combination with other...


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Targeting the tumor stroma with an oncolytic adenovirus secreting a fibroblast activation protein-targeted bispecific T-cell engager

Published in the Journal for ImmunoTherapy of Cancer (JITC), is a research article demonstrating that the combination of viral oncolysis of cancer cells and FBiTE-mediated cytotoxicity of FAP-expressing CAFs might be an effective strategy to overcome a key limitation of oncolytic virotherapy,...



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Chemo-immunotherapy improves long-term survival in a preclinical model of MMR-D-related cancer

Published in the Journal for ImmunoTherapy of Cancer (JITC), is a research article where researchers explained how vaccination were combined with single low-dose chemotherapy as precondition to polarize immunosuppressive cells and thus modulate the immune system. Authors: Claudia Maletzki , ...