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Population pharmacokinetics, exposure-safety, and immunogenicity of atezolizumab in pediatric and young adult patients with cancer

The iMATRIX-atezolizumab study was a phase I/II, multicenter, open-label study designed to assess the safety and pharmacokinetics of atezolizumab in pediatric and young adult patients. The authors describe the pharmacokinetics, exposure-safety, and immunogenicity of atezolizumab in pediatric and...



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Tumor immune microenvironment and genomic evolution in a patient with metastatic triple negative breast cancer and a complete response to atezolizumab

Metastatic TNBC (mTNBC) has a poor prognosis and few treatment options. The anti-PD-L1 antibody atezolizumab demonstrated clinical activity in mTNBC patients with PD-L1-positive tumor-infiltrating immune cells. The current study describes the tumor immune microenvironment (TiME) and genomic...


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Late-differentiated effector neoantigen-specific CD8+ T cells are enriched in peripheral blood of non-small cell lung carcinoma patients responding to atezolizumab treatment

There is strong evidence that immunotherapy-mediated tumor rejection can be driven by tumor-specific CD8+ T cells reinvigorated to recognize neoantigens derived from tumor somatic mutations. Thus, the frequencies or characteristics of tumor-reactive, mutation-specific CD8+ T cells could be used...




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Lung Cancer Living Room™ - Spanish Edition - A Resource from the GO2 Foundation for Lung Cancer

Every month the GO 2 Foundation for Lung Cancer presents their "Lung Cancer Living Room™" a patient education and support series created for patients and their families. Through presentations by lung cancer specialists, physicians, and researchers, this unrestricted, relaxed forum covers all...


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Lung Cancer Living Room™ - Chinese Edition - A Resource from the GO2 Foundation for Lung Cancer

Every month the GO 2 Foundation for Lung Cancer presents their "Lung Cancer Living Room™" a patient education and support series created for patients and their families. Through presentations by lung cancer specialists, physicians, and researchers, this unrestricted, relaxed forum covers all...


Library Entry
Lung Cancer Living Room™ - A Resource from the GO2 Foundation for Lung Cancer

Every month the GO 2 Foundation for Lung Cancer presents their "Lung Cancer Living Room™" a patient education and support series created for patients and their families. Through presentations by lung cancer specialists, physicians, and researchers, this unrestricted, relaxed forum covers all...