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B cell depletion or absence does not impede anti-tumor activity of PD-1 inhibitors

Published in the Journal for ImmunoTherapy of Cancer (JITC), is a short report discussing the role of B cells in the anti-tumor activity of PD-1 inhibitors and their activity in mouse models receiving B cell depleting drugs or with immunoglobulin deficiencies. Authors: William Damsky , Lucia...


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CD45RA+CCR7− CD8 T cells lacking co-stimulatory receptors demonstrate enhanced frequency in peripheral blood of NSCLC patients responding to nivolumab

Published in the Journal for ImmunoTherapy of Cancer (JITC), is a research article demonstrating that high numbers of peripheral CD8 T cells expressing differentiation markers and lacking co-stimulatory receptors at baseline are associated with response to nivolumab in NSCLC patients. Authors: ...


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DNA damage repair gene mutations and their association with tumor immune regulatory gene expression in muscle invasive bladder cancer subtypes

Published in the Journal for ImmunoTherapy of Cancer (JITC), is a research article providing evidence for co-expression of multiple immune checkpoint genes including, PD-1 , PD-L1, IDO1, TIGIT, TIM-3, TGFB1, LAG3, and others, that potentially contribute to compensatory immune evasion in...


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PD-L1 detection using 89Zr-atezolizumab immuno-PET in renal cell carcinoma tumorgrafts from a patient with favorable nivolumab response

Published in the Journal for ImmunoTherapy of Cancer (JITC), is a case report discussing immuno-PET studies of PD-L1 in a preclinical tumorgraft model of clear cell RCC (ccRCC) from a patient who had a favorable response to anti-PD-1 therapy. Authors: Joseph Vento , Aditi Mulgaonkar , ...


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Prognostic impact of immune gene expression signature and tumor infiltrating immune cells in localized clear cell renal cell carcinoma

Published in the Journal for ImmunoTherapy of Cancer (JITC), is a research article investigating the correlation of tumor infiltrating immune cell characteristics with rates of recurrence following surgery in localized ccRCC. Authors: Pooja Ghatalia , Jennifer Gordetsky , Fengshen Kuo , ...


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Paired whole exome and transcriptome analyses for the Immunogenomic changes during concurrent chemoradiotherapy in esophageal squamous cell carcinoma

Published in the Journal for ImmunoTherapy of Cancer (JITC), is a research article seeking to analyze the early immunogenomic changes in ESCC induced by CCRT and to correlate them with clinical outcomes. The results provide a potential basis for combining immunotherapy with CCRT for the...



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Advances in Cancer Immunotherapy™ Webinar Series: Updates from the Field - Clinical Updates from SITC 2018 (Presentation Slides)

This webinar provided an update on developments in the field relating to content presented at the Advances in Cancer Immunotherapy programs and focused on applicable information for a clinical audience. More specifically, program organizers Christian M. Capitini, MD, and Zachary S. Morris,...

Advances in Cancer Immunotherapy Updates from the Field - Clinical Updates from SITC 2018.pdf