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Hyperspectral cell sociology reveals spatial tumor-immune cell interactions associated with lung cancer recurrence

Published in the Journal for ImmunoTherapy of Cancer (JITC), is a research article concludes that Hyperspectral Cell Sociology expands our understanding of the complex interplay between tumor cells and immune infiltrate. This technology could improve predictions of responses to immunotherapy and...


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Chimeric tumor modeling reveals role of partial PDL1 expression in resistance to virally induced immunotherapy

Published in the Journal for ImmunoTherapy of Cancer (JITC), is a research article indicating that the responsiveness of partially PDL1 + tumors correlates linearly with the percentage of PDL1 capable cells present at the initiation of treatment. Additionally, tumors which relapse after...


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Advances in Cancer Immunotherapy™ Webinar Series: Updates from the Field - Clinical Updates from SITC 2018

This webinar provided an update on developments in the field relating to content presented at the Advances in Cancer Immunotherapy programs and focused on applicable information for a clinical audience. More specifically, program organizers Christian M. Capitini, MD, and Zachary S. Morris,...


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Advances in Cancer Immunotherapy™ Webinar Series - Updates from the Field: ESMO Congress Clinical Trials Recording

This webinar provided an update on developments in the field relating to content presented at the Advances in Cancer Immunotherapy programs and focused on applicable information for a clinical audience. More specifically, program organizers Theodore F. Logan, MD, and David F. McDermott, MD,...



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High and low mutational burden tumors versus immunologically hot and cold tumors and response to immune checkpoint inhibitors

Published in the Journal for ImmunoTherapy of Cancer (JITC), is a commentary on the evaluation of tumors based on both their immune phenotype and genomic mutation profile to determine which patients have a higher likelihood of responding to treatment with ICIs. Author: Saman Maleki Vareki ...


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Non-invasive biomarkers derived from the extracellular matrix associate with response to immune checkpoint blockade (anti-CTLA-4) in metastatic melanoma patients

Published in the Journal for ImmunoTherapy of Cancer (JITC), is a research article that evaluates the association between serum biomarkers of collagen and vimentin turnover and outcomes in metastatic melanoma patients treated with the anti-CTLA-4 antibody ipilimumab (IPI). Authors: Christina...



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SITC 2018 workshop report: Immuno-Oncology Biomarkers: State of the Art

Published in the Journal for ImmunoTherapy of Cancer (JITC), is a report on t he results of the 2018 Immuno-Oncology Biomarker: State of the Art Workshop include the development of new initiatives for the SITC Biomarkers Committee. Authors: Lisa H. Butterfield , Mary L. Disis , Bernard A....


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Immunotherapy utilizing the combination of natural killer– and antibody dependent cellular cytotoxicity (ADCC)–mediating agents with poly (ADP-ribose) polymerase (PARP) inhibition

Published in the Journal for ImmunoTherapy of Cancer (JITC), is a research article which examined if olaparib, when combined with IgG 1 antibody-dependent cellular cytotoxicity (ADCC)-mediating monoclonal antibodies (mAbs) cetuximab (anti-EGFR), or avelumab (anti-PD-L1), would increase tumor...