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Merger of dynamic two-photon and phosphorescence lifetime microscopy reveals dependence of lymphocyte motility on oxygen in solid and hematological tumors

Published in the Journal for ImmunoTherapy of Cancer (JITC), is a research article finding both in bone marrow leukemia and solid tumor models, TILs encountered regions of varying oxygen concentrations, including regions of hypoxia (defined as pO 2 below 5 mmHg), especially in advanced-stage...


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Expression and clinical significance of PD-L1, B7-H3, B7-H4 and TILs in human small cell lung Cancer (SCLC)

Published in the Journal for ImmunoTherapy of Cancer (JITC), is a research article in which the levels of 3 different B7 family ligands PD-L1, B7-H3, B7-H4 and major tumor infiltrating lymphocyte (TIL) subsets in 90 SCLC samples represented in tissue microarray format were measured using...


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Radiotherapy enhances responses of lung cancer to CTLA-4 blockade

Published in the Journal for ImmunoTherapy of Cancer (JITC), is a research article editorial discussing the clinical outcomes and translational readouts of a trial by Formenti et al.of the anti-CTLA-4 inhibitor, ipilimumab, in combination with palliative radiotherapy in 39 patients with non...


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α-PD-1 therapy elevates Treg/Th balance and increases tumor cell pSmad3 that are both targeted by α-TGFβ antibody to promote durable rejection and immunity in squamous cell carcinomas

Published in the Journal for ImmunoTherapy of Cancer (JITC), is a research article showing that α-PD-1 not only initiates a tumor rejection program, but can induce a competing TGFβ-driven immuno-suppressive program. Additionally, the article identifoes new opportunities for α-PD-1/α-TGFβ...


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Intralymphatic histiocytosis in a patient with lung adenocarcinoma treated with pembrolizumab: a case report

Published in the Journal for ImmunoTherapy of Cancer (JITC), is a research article detailing a case in which a 67-year-old man with lung adenocarcinoma who developed ILH associated with pembrolizumab treatment. He was treated with palliative thoracic radiotherapy for superior vena cava syndrome....


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Phase Ib evaluation of a self-adjuvanted protamine formulated mRNA-based active cancer immunotherapy, BI1361849 (CV9202), combined with local radiation treatment in patients with stage IV non-small c

Published in the Journal for ImmunoTherapy of Cancer (JITC), is a research article describing a phase Ib clinical trial evaluating treatment with BI1361849 combined with local radiation in 26 stage IV NSCLC patients with partial response (PR)/stable disease (SD) after standard first-line therapy...


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Proliferative potential and resistance to immune checkpoint blockade in lung cancer patients

Published in the Journal for ImmunoTherapy of Cancer (JITC), is a research article in which tumor specimens from 120 NSCLC patients from 10 institutions were evaluated for PD-L1 expression by immunohistochemistry, and global proliferative profile by targeted RNA-seq. The article concludes that...



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Hyperspectral cell sociology reveals spatial tumor-immune cell interactions associated with lung cancer recurrence

Published in the Journal for ImmunoTherapy of Cancer (JITC), is a research article concludes that Hyperspectral Cell Sociology expands our understanding of the complex interplay between tumor cells and immune infiltrate. This technology could improve predictions of responses to immunotherapy and...