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CD45RA+CCR7− CD8 T cells lacking co-stimulatory receptors demonstrate enhanced frequency in peripheral blood of NSCLC patients responding to nivolumab

Published in the Journal for ImmunoTherapy of Cancer (JITC), is a research article demonstrating that high numbers of peripheral CD8 T cells expressing differentiation markers and lacking co-stimulatory receptors at baseline are associated with response to nivolumab in NSCLC patients. Authors: ...


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Automated image analysis of NSCLC biopsies to predict response to anti-PD-L1 therapy

Published in the Journal for ImmunoTherapy of Cancer (JITC), is a research article reporting an automated image analysis solution to determine the predictive and prognostic values of the product of PD-L1+ cell and CD8+ tumor infiltrating lymphocyte (TIL) densities (CD8xPD-L1 signature) in...


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Biomarker Testing: Inhale for Life

If you’ve been diagnosed with non-small cell lung cancer, you should ask your doctor about comprehensive biomarker testing. For some kinds of lung cancer, comprehensive biomarker testing may provide information on whether there are changes in the cancer cells that can be treated with targeted...


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Treatment Option for Squamous Cell Lung Cancer (from LUNGevity)

There are numerous treatment options available to people diagnosed with squamous cell lung cancer, and doctors are working hard to develop and improve these treatments. This website can help you: Learn about squamous cell lung cancer Understand the treatment options available for squamous...


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Treatment Options for Lung Adenocarcinoma (from LUNGevity)

There are numerous treatment options available to people affected by lung adenocarcinoma, and doctors are working hard to develop and improve these treatments. This website from LUNGevity can help you: Learn about lung adenocarcinoma Understand the treatment options available for lung...


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Severe cytokine release syndrome resulting in purpura fulminans despite successful response to nivolumab therapy in a patient with pleomorphic carcinoma of the lung: a case report

Published in the Journal for ImmunoTherapy of Cancer (JITC), is a case report presenting the case of a 52-year-old woman with successful regression of pleomorphic carcinoma of the lung following nivolumab therapy. Osamu Honjo , Terufumi Kubo , Fumiko Sugaya , Takahiro Nishizaka , ...


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Determinant roles of dendritic cell-expressed Notch Delta-like and Jagged ligands on anti-tumor T cell immunity

Published in the Journal for ImmunoTherapy of Cancer (JITC), is a research article exploring the roles of dendritic cell (DC)-expressed Notch ligands in the regulation of T-cell effector function. Elena E. Tchekneva , Mounika U.L. Goruganthu , Roman V. Uzhachenko , Portia L. Thomas , ...


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Use of targeted next generation sequencing to characterize tumor mutational burden and efficacy of immune checkpoint inhibition in small cell lung cancer

Published in the Journal for ImmunoTherapy of Cancer (JITC), is a research article detemining whether TMB by targeted NGS is associated with efficacy of ICIs in patients with SCLC Authors: Biagio Ricciuti , Sasha Kravets , Suzanne E. Dahlberg , Renato Umeton , Adem Albayrak , Safiya J....


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Immune-enrichment of non-small cell lung cancer baseline biopsies for multiplex profiling define prognostic immune checkpoint combinations for patient stratification

Published in the Journal for ImmunoTherapy of Cancer (JITC), is a research article in which an innovative, tumor heterogeneity reducing, immune-enriched tissue microarray was constructed from baseline biopsies, and multiplex immunofluorescence was used to profile 25 immune-checkpoints and immune...


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Merger of dynamic two-photon and phosphorescence lifetime microscopy reveals dependence of lymphocyte motility on oxygen in solid and hematological tumors

Published in the Journal for ImmunoTherapy of Cancer (JITC), is a research article finding both in bone marrow leukemia and solid tumor models, TILs encountered regions of varying oxygen concentrations, including regions of hypoxia (defined as pO 2 below 5 mmHg), especially in advanced-stage...