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Tbet-positive regulatory T cells accumulate in oropharyngeal cancers with ongoing tumor-specific type 1 T cell responses

Published in the Journal for ImmunoTherapy of Cancer (JITC), is a research article showing that high numbers of both conventional and Tbet co-expressing Foxp3 hi Tregs accumulate in human papilloma virus (HPV)-driven oropharyngeal squamous cell carcinoma (OPSCC). The infiltration of Tbet+...

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Hyperspectral cell sociology reveals spatial tumor-immune cell interactions associated with lung cancer recurrence

Published in the Journal for ImmunoTherapy of Cancer (JITC), is a research article concludes that Hyperspectral Cell Sociology expands our understanding of the complex interplay between tumor cells and immune infiltrate. This technology could improve predictions of responses to immunotherapy and...

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Chimeric tumor modeling reveals role of partial PDL1 expression in resistance to virally induced immunotherapy

Published in the Journal for ImmunoTherapy of Cancer (JITC), is a research article indicating that the responsiveness of partially PDL1 + tumors correlates linearly with the percentage of PDL1 capable cells present at the initiation of treatment. Additionally, tumors which relapse after...

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Cutaneous adverse reactions in B-RAF positive metastatic melanoma following sequential treatment with B-RAF/MEK inhibitors and immune checkpoint blockade or vice versa. A single-institutional case-se

Published in the Journal for ImmunoTherapy of Cancer (JITC), is a case report on patients treated with immune-checkpoint blockade followed by targeted therapy, or vice versa, who experienced cutaneous toxicities with unique histological patterns, a feature that has not been well described in...

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Advances in Cancer Immunotherapy™ Webinar Series: Updates from the Field - Clinical Updates from SITC 2018

This webinar provided an update on developments in the field relating to content presented at the Advances in Cancer Immunotherapy programs and focused on applicable information for a clinical audience. More specifically, program organizers Christian M. Capitini, MD, and Zachary S. Morris,...

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Advances in Cancer Immunotherapy™ Webinar Series - Updates from the Field: ESMO Congress Clinical Trials Recording

This webinar provided an update on developments in the field relating to content presented at the Advances in Cancer Immunotherapy programs and focused on applicable information for a clinical audience. More specifically, program organizers Theodore F. Logan, MD, and David F. McDermott, MD,...

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Primer on Cancer Immunology and Immunotherapy

Primer on Cancer Immunology and Immunotherapy International Conference on Immunotherapy Radiotherapy Combinations September 20, 2018 Presentered by Gustave Roussy and SOCRATE, in collaboration with the Society for Immunotherapy of Cancer Program Summary Over 420 attendees from 4 continents,...

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Nephrotoxicity of immune checkpoint inhibitors beyond tubulointerstitial nephritis: single-center experience

Published in the Journal for ImmunoTherapy of Cancer (JITC), is a short report of cases of biopsy proven acute tubulointerstitial nephritis (ATIN) and glomerulonephritis (GN) induced by CPIs and discuss potential mechanisms of these adverse effects. Authors: Omar Mamlouk , Umut Selamet , ...

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Complete response of metastatic melanoma in a patient with Crohn’s disease simultaneously receiving anti-α4β7 and anti-PD1 antibodies

Published in the Journal for ImmunoTherapy of Cancer (JITC), is a case report of a man with Crohn’s disease actively requiring immunosuppressive therapy who subsequently received pembrolizumab for metastatic melanoma. Authors: Christopher C. Frohne , Ernesto M. Llano , Ashley Perkovic , ...

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Infliximab for treatment-refractory transverse myelitis following immune therapy and radiation

Published in the Journal for ImmunoTherapy of Cancer (JITC), is a case report of a 68-year-old with metastatic melanoma, who developed transverse myelitis in the setting of immune checkpoint blockade and spinal irradiation for vertebral metastases. Authors: Victoria A. Chang , Daniel R....