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Mechanisms involved in IL-15 superagonist enhancement of anti-PD-L1 therapy

Published in the Journal for ImmunoTherapy of Cancer (JITC), is a research article examining the anti­tumor efficacy and immunomodulatory effects of combining N-803 with an anti-PD-L1 antibody in preclinical models of solid carcinomas refractory to anti-PD-L1 or N-803. Authors: Karin M....


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Phase 1/2 study of epacadostat in combination with ipilimumab in patients with unresectable or metastatic melanoma

Published in the Journal for ImmunoTherapy of Cancer (JITC), is a research article concluding that when combined with ipilimumab, epacadostat ≤50 mg BID demonstrated clinical and pharmacologic activity and was generally well tolerated in patients with advanced melanoma. Authors: Geoffrey T....


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Complete response of renal cell carcinoma vena cava tumor thrombus to neoadjuvant immunotherapy

Published in the Journal for ImmunoTherapy of Cancer (JITC), is a research article case report detailing a 54-year-old female diagnosed with a locally advanced clear cell renal cell carcinoma with a level IV tumor thrombus of the vena cava. Preoperative immunotherapy with nivolumab and...


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Expression and clinical significance of PD-L1, B7-H3, B7-H4 and TILs in human small cell lung Cancer (SCLC)

Published in the Journal for ImmunoTherapy of Cancer (JITC), is a research article in which the levels of 3 different B7 family ligands PD-L1, B7-H3, B7-H4 and major tumor infiltrating lymphocyte (TIL) subsets in 90 SCLC samples represented in tissue microarray format were measured using...


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Radiotherapy enhances responses of lung cancer to CTLA-4 blockade

Published in the Journal for ImmunoTherapy of Cancer (JITC), is a research article editorial discussing the clinical outcomes and translational readouts of a trial by Formenti et al.of the anti-CTLA-4 inhibitor, ipilimumab, in combination with palliative radiotherapy in 39 patients with non...


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Exceptional response and multisystem autoimmune-like toxicities associated with the same T cell clone in a patient with uveal melanoma treated with immune checkpoint inhibitors

Published in the Journal for ImmunoTherapy of Cancer (JITC), is a research article case report of a patient with wide spread uveal melanoma who had an exceptional response to treatment with ipilimumab and nivolumab, but suffered severe immune-related sequelae, including central serous...


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α-PD-1 therapy elevates Treg/Th balance and increases tumor cell pSmad3 that are both targeted by α-TGFβ antibody to promote durable rejection and immunity in squamous cell carcinomas

Published in the Journal for ImmunoTherapy of Cancer (JITC), is a research article showing that α-PD-1 not only initiates a tumor rejection program, but can induce a competing TGFβ-driven immuno-suppressive program. Additionally, the article identifoes new opportunities for α-PD-1/α-TGFβ...


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A multicenter study of body mass index in cancer patients treated with anti-PD-1/PD-L1 immune checkpoint inhibitors: when overweight becomes favorable

Published in the Journal for ImmunoTherapy of Cancer (JITC), is a research article investigating the potential correlation between overweight and the efficacy of immune checkpoint inhibitors (ICIs) in cancer patients. Authors: Alessio Cortellini , Melissa Bersanelli , Sebastiano Buti , ...


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The immune suppressive microenvironment of human gliomas depends on the accumulation of bone marrow-derived macrophages in the center of the lesion

Published in the Journal for ImmunoTherapy of Cancer (JITC), is a research article in which Myeloid and lymphoid infiltrate were characterized in grade II, III and IV gliomas by multicolor flow cytometry, along with the composition of the cell subsets of circulating myeloid cells. Macrophages...


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Increased intratumoral mast cells foster immune suppression and gastric cancer progression through TNF-α-PD-L1 pathway

Published in the Journal for ImmunoTherapy of Cancer (JITC), is a research article seeking to illuminate the nature, regulation, function, and clinical relevance of mast cells in human gastric cancer (GC). Authors: Yipin Lv , Yongliang Zhao , Xianhua Wang , Na Chen , Fangyuan Mao , ...