2024 Spring Scientific - Schedule

Metabolism at the Hub of Cancer and Immunity

MARCH 10–12, 2024

PLEASE NOTE: Daylight Savings Time begins on Sunday, March 10, 2024. Spring Scientific sessions begin at 9 a.m. EDT on Sunday, March 10, 2024. 

Sunday, March 10

Registration & Breakfast  |  8-9 a.m. ET

Opening Remarks

9-9:10 a.m ET  |  Bayfront Ballroom  | 

Greg M. Delgoffe, PhD – University of Pittsburgh

Keynote Address
9:10–10:10 a.m. ET

9:10 a.m.

Functional Genomics and Systems Immunology in Mapping the Metabolic Basis of Cancer Immunity
Hongbo Chi, PhD – St. Jude Children's Research Hospital

10 a.m.

Question and Answer

Session I: Cancer Metabolism and Metastasis
10:10-11:30 a.m. ET

10:10 a.m.
Influence of Nutrient Environment on Immune Response
Matthew Vander Heiden, MD, PhD – Koch Institute at MIT 
10:30 a.m.

Metabolic and Immune Characteristics of Melanoma Metastasis in the Brain
Vashisht Yennu Nanda, PhD – The University of Texas MD Anderson Cancer Center

10:50 a.m.

Measuring the Metabolism of Tumors and Inflamed Tissues In Vivo
Caroline R. Bartman, PhD – University of Pennsylvania

11:10 a.m.

(58) Role of Drp1 in Mediating Immune Suppressive TME in KRAS Mutant Pancreatic Cancer
Victoria A. Remley, BS – University of Virginia

11:20 a.m.

(78) Targeting lipid metabolism to improve PARP inhibitor response in BRCA-associated TNBC
Carlos Wagner S. Wanderley, PhD – Brigham and Women's Hospital

Lunch & Poster Preview

11:30 a.m.-1 p.m. ET

(Odd numbered posters will be presented on Sunday, March 10, 2024)

Session II: Cancer Metabolism and Tumor Microenvironment
1–2:20 p.m. ET

1 p.m. Metabolic Impact on Cancer Immunotherapy
Weiping Zou, MD, PhD – University of Michigan 
1:20 p.m.

Metabolic Networks in the Tumor Microenvironment
Costas A. Lyssiotis, PhD – University of Michigan 

1:40 p.m.

Compartmentalization of Cofactor Metabolism
Nathaniel W. Snyder, PhD, MPH, DABT – Temple University

2 p.m.

(9) Fatty Acids in Ovarian Cancer Ascites Contribute to Impaired T Cell Function Independent of CD36
Erica G. Brown, BS – University of Pennsylvania

2:10 p.m.

(80) Intercellular Highways Pave the Way for Protumorigenic Mitochondria Transfer in Glioblastoma
Dionysios C. Watson, MD, PhD – University of Miami

Session III:  Interactions Between Systemic Metabolism and Cancer Metabolism
2:20–3:40 p.m. ET

2:20 p.m.

A Metabolic Switch that Boosts Immune Cell Fitness Against Cancer
Semir Beyaz, PhD – Cold Spring Harbor Laboratory 

2:40 p.m.

Paradoxical Effects of Obesity on Tumor Metabolism and Therapeutic Response
Jennifer L. McQuade, MD – The University of Texas MD Anderson Cancer Center

3 p.m.

Adjuvant Effects of Obesity on Resident Dendritic Cells
Tim O'Sullivan, PhD – University of California, Los Angeles

3:20 p.m.

(37) MEF2C Regulates NK Cell Effector Functions Through Control of Lipid Metabolism
Joey Li – University of California, Los Angeles

3:30 p.m.

(65) Germline Genetic Variation Shape the Lipid Metabolic & Immune Landscapes of Cancer
Rosalyn W. Sayaman, PhD – University of California, San Francisco

Break

3:40–4 p.m. ET

Workshop: Technical Frontiers in Immunometabolism and Tumor Microenvironment
4–6 p.m. ET

4 p.m.

Spatial Metabolomics with Cellular Resolution
Nathalie Agar, PhD – Harvard University

4:20 p.m.

Imaging T cell Metabolism with Single-cell Resolution
Melissa Skala, PhD – Morgridge Institute for Research

4:40 p.m.

In situ Tumor Arrays Reveal Environmental Control of Cancer Immunity
Christine Moussion, PhD – Genentech

5 p.m.

New Analytical Tools for Deeper Insights into Immune Cell Metabolism and Function
Natalia Romero, PhD – Agilent Technologies, Inc. 

5:15 p.m.

Continuous and Long Term Cell Culture Oxygen Consumption Rate Analysis Utilizing Resipher
Ryan Titmas, MBA – Lucid Scientific, Inc.

5:30 p.m.

Panel Discussion – What's Next?

Abstract Poster Session & Networking Reception 

6-7 p.m. ET

(Odd numbered posters will be presented on Sunday, March 10, 2024) 

Monday, March 11

Registration & Breakfast (Career Development Panel Discussion - Advice over breakfast for early career researchers)    |  8-9 a.m. ET

Career Development Panel Discussion

8-9 a.m ET

Moderators:

Greg M. Delgoffe, PhD – University of Pittsburgh 

Jennifer L. Guerriero, PhD – Brigham and Women's Hospital

Panel:

Caroline R. Bartman, PhD – University of Pennsylvania 

Juan R. Cubillos-Ruiz, PhD – Weill Cornell Medicine 

James L. Gulley, MD, PhD, FACP – National Cancer Institute

Jennifer L. McQuade, MD – The University of Texas MD Anderson Cancer Center 

Amber Mueller, PhD  – Cell Metabolism

Alexia-Ileana Zaromytidou, PhD – Nature Cancer 

Opening Remarks

9-9:05 a.m ET  |  Bayfront Ballroom |

Greg M. Delgoffe, PhD – University of Pittsburgh &

Jennifer L. Guerriero, PhD – Brigham and Women’s Hospital 

Session IV:  Metabolism of Adaptive Anti-tumor Immunity
9:05–10:25 a.m. ET

9:05 a.m. Metabolic Factors Underlying T cell Exhaustion
Greg M. Delgoffe, PhD – University of Pittsburgh 
9:25 a.m.

Impact of Tumor Metabolism on the Immune-Vascular Architecture of the Tumor Microenvironment: Implications for Cancer Immunotherapy
Roberta Zappasodi, PhD – Weill Cornell Medicine

9:45 a.m.

Environmental Bottlenecks on T-cell Immunity
Santosha A. Vardhana, MD, PhD – Memorial Sloan Kettering Cancer Center 

10:05 a.m.

(32) Acetyl-CoA Carboxylase Obstructs CD8+ T-cell Lipid Utilization in the Tumor Microenvironment
Elizabeth Hunt – University of North Carolina at Chapel Hill

10:15 a.m.

(36) Mitochondrial Regulator REXO2 is Essential for the Anti-tumor T Cell Immunity
Soundharya Kumaresan, MS – Winship Cancer Institute at Emory University

Break

10:25–10:45 a.m. ET

Session V:  Myeloid Cell Metabolism in the Context of Cancer
10:45 a.m.–12:05 p.m. ET

10:45 a.m. Tumor Promoting Macrophage Differentiation
Edward J. Pearce, PhD – Johns Hopkins School of Medicine
11:05 a.m.

Targeting Macrophage Lipid Metabolism to Enhance Anti-tumor Responses
Jennifer L. Guerriero, PhD – Brigham and Women’s Hospital 

11:25 a.m.

Innate Immune Control of Tumor Development
Ivan Zanoni, PhD – Harvard Medical School  - Boston Children’s Hospital 

11:45 a.m. (5) AXL Limits the Mobilization of Cholesterol to Regulate Dendritic Cell Maturation & the Immunogenic Response to Cancer
Meriem Belabed, PhD – Icahn School of Medicine at Mount Sinai
11:55 a.m.

(88) VISTA modulates the metabolic signature of myeloid-derived suppressor cells by regulating polyamine biosynthesis and mitochondrial function
Amin Zakeri, PhD – Cleveland Clinic Foundation

Lunch & Poster Preview

                                             Meet-the-Editors (JITC, Cell Metabolism, Nature Cancer)

12:05–1:25 p.m. ET

(Even numbered posters will be presented on Monday, March 11, 2024) 

Session VI:  Metabolic Stress in Anti-tumor Immunity
1:25 p.m.–2:45 p.m. ET

1:25 p.m. Restructuring T-Cell Lipid Utilization in Tumors
Jessica Thaxton, PhD, MS – University of North Carolina at Chapel Hill 
1:45 p.m.

Immunometabolic Programs Controlled by ER Stress in Cancer
Juan R. Cubillos-Ruiz, PhD – Weill Cornell Medicine 

2:05 p.m.

Metabolic Polarization of Myeloid Cells in Tumors
Paulo C. Rodriguez, PhD – Moffitt Cancer Center 

2:25 p.m.

(60) Sheltering Telomeres From Oxidative Damage in Therapeutic T Cells Protects Against Tumor-induced Immune Dysfunction
Dayana Rivadeneira, PhD – University of Pittsburgh

2:35 p.m.

(61) Characterization of Myeloid-derived Suppressor Cells in Response to Restraint Stress in Preclinical Models of Ovarian Cancer
Yadiel A. Rivera-Lopez, BS – Ponce Health Sciences University

Break

2:45–3:10 p.m. ET

Workshop: Metabolic Improvements of Cell Therapies
3:10–5:15 p.m. ET 

3:10 p.m. Optimizing Fuel Selection for CAR T cells
Roddy O'Connor, PhD, MS, BSc – University of Pennsylvania
3:30 p.m.

Immunometabolic Reprogramming of Natural Killer Cells for Immunotherapy of Solid Tumors
Sandro Matosevic, PhD – Purdue University 

3:50 p.m.

Progressively Enhancing Stemness of Adoptive Transferred CD8 T cells with PI3K Delta Blockade Improve Metabolism and Antitumor Immunity
Chrystal M. Paulos, PhD – Winship Cancer Institute at Emory University 

4:10 p.m.

Tools for Bringing Key Metabolite Measurements to the Point of Use in the Development of Cell Therapies
Will Thompson, PhD – 908 Devices 

4:25 p.m.

(27) Redirecting Glucose Flux During in Vitro Expansion Generates Epigenetically & Metabolically Superior T cells for Cancer Immunotherapy
Andrew Frisch, BS – University of Pittsburgh

4:35 p.m.

(29) IL-18-enhanced non-activated CAR T-cells for Improved Metabolic Function & Therapeutic Efficacy
Saba Ghassemi, PhD – Center for Cellular Immunotherapies, Perelman School of Medicine at the University of Pennsylvania

4:45 p.m.

Panel Discussion – What's Next?

Abstract Poster Session & Networking Reception

5:15-6:45 p.m. ET

(Even numbered posters will be presented on Monday, March 11, 2024) 

Tuesday, March 12

Registration & Breakfast  |  7-8 a.m. ET

Opening Remarks

8-8:05 a.m. ET |  Bayfront Ballroom | 

Greg M. Delgoffe, PhD – University of Pittsburgh &

Jennifer L. Guerriero, PhD – Brigham and Women’s Hospital 

 

Session VII:  Microbiome and Tumor Microenvironment
8:05–9:25 a.m. ET

8:05 a.m.

Understanding Intratumoral Microbes in Human Cancers
Christopher D. Johnston, PhD – Fred Hutchinson Cancer Center 

8:25 a.m.

Presentation Title TBA
Laurence Zitvogel, MD, PhD – Institut Gustave Roussy

8:45 a.m.

Microbes & Their Influence in Remote Tumors Behavior
Florencia McAllister, MD – The University of Texas MD Anderson Cancer Center 

9:05 a.m.

(17) Harnessing Gut Microbiota & Microbial-derived Short-chain Fatty Acids to Improve Combinatorial Chemotherapy/Immunotherapy Efficacy in Triple-negative
Kenysha YJ Clear, BS – Wake Forest University School of Medicine

9:15 a.m.

(47) The Oral Microbiome Can Modulate the Tumor Microenvironment in Metastatic Brain Tumors
Golnaz Morad, DDS, PhD – The University of Texas MD Anderson Cancer Center

Break

9:25–9:45 a.m. ET

Session VIII:  Microbiome Interaction with Immunity in Cancer
9:45–11:05 a.m. ET

9:45 a.m.

Dietary Modifications of Lachnospiraceae Abundance Promotes Response to Immune Checkpoint Blockade
Daniel Spakowicz, PhD – The Ohio State University Medical Center 

10:05 a.m.

Presentation Title TBA
Guido Kroemer, MD, PhD – Institut Gustave Roussy

10:25 a.m.

Sickeningly Sweet: Diet and Microbiome Control of the Tumor Microenvironment
Abby E. Overacre, PhD – University of Pittsburgh

10:45 a.m.

(2) Spatial Profiling Reveals Modulation of the Immune Microenvironment in Rectal Adenocarcinoma by Tumor-Associated Microbes
Reed I. Ayabe, MD – The University of Texas MD Anderson Cancer Center

10:55 a.m.

(16) Microbial Regulation of Anti-tumor Immunity in Metastatic Colorectal Cancer
Charlie Chung – Cold Spring Harbor Laboratory

Break

11:05–11:25 a.m. ET

Session IX:  Translational Relevance: Modulating Cancer and Immune Metabolism in the Clinic
11:25 a.m.–12:45 p.m. ET

11:25 a.m. Systemic, Immune, & Anti-tumor Effect of a Lactate Dehydrogenase Inhibitor
Chi V. Dang, MD, PhD – Johns Hopkins University School of Medicine
11:45 a.m.

Temperature: The Overlooked Factor in the Tumor Microenvironment
Jeffrey C. Rathmell, PhD – Vanderbilt University Medical Center

12:05 p.m.

Microbiome-based Interventions in Oncology Patients
Saman Maleki, PhD – Western University

12:25 p.m.

(19) Window of Opportunity for Durvalumab Plus Metformin Trial for Squamous Cell Carcinoma of the Head & Neck (HNSCC)
Joseph Curry, MD – Thomas Jefferson University

12:35 p.m.

(68) Metabolic, Genetic & Inflammatory Endpoints as Biomarkers of Immune Checkpoint Therapy Efficacy & Immune-Related Adverse Events
David R. Soto-Pantoja, PhD – Wake Forest University School of Medicine

Closing Remarks

12:45–12:50 p.m. ET  |  Bayfront Ballroom | 

Greg M. Delgoffe, PhD – University of Pittsburgh &

Jennifer L. Guerriero, PhD – Brigham and Women’s Hospital