Keynote Address
9:10–10:10 a.m. ET

Functional Genomics and Systems Immunology in Mapping the Metabolic Basis of Cancer Immunity
Hongbo Chi, PhD – St. Jude Children's Research Hospital

Question and Answer

Session I: Cancer Metabolism and Metastasis
10:10-11:30 a.m. ET

Metabolic and Immune Characteristics of Melanoma Metastasis in the Brain
Vashisht Yennu Nanda, PhD – The University of Texas MD Anderson Cancer Center

Measuring the Metabolism of Tumors and Inflamed Tissues In Vivo
Caroline R. Bartman, PhD – University of Pennsylvania

(58) Role of Drp1 in Mediating Immune Suppressive TME in KRAS Mutant Pancreatic Cancer
Victoria A. Remley, BS – University of Virginia

(78) Targeting lipid metabolism to improve PARP inhibitor response in BRCA-associated TNBC
Carlos Wagner S. Wanderley, PhD – Brigham and Women's Hospital

Session II: Cancer Metabolism and Tumor Microenvironment
1–2:20 p.m. ET

Metabolic Networks in the Tumor Microenvironment
Costas A. Lyssiotis, PhD – University of Michigan 

Compartmentalization of Cofactor Metabolism
Nathaniel W. Snyder, PhD, MPH, DABT – Temple University

(9) Fatty Acids in Ovarian Cancer Ascites Contribute to Impaired T Cell Function Independent of CD36
Erica G. Brown, BS – University of Pennsylvania

(80) Intercellular Highways Pave the Way for Protumorigenic Mitochondria Transfer in Glioblastoma
Dionysios C. Watson, MD, PhD – University of Miami

Session III:  Interactions Between Systemic Metabolism and Cancer Metabolism
2:20–3:40 p.m. ET

A Metabolic Switch that Boosts Immune Cell Fitness Against Cancer
Semir Beyaz, PhD – Cold Spring Harbor Laboratory 

Paradoxical Effects of Obesity on Tumor Metabolism and Therapeutic Response
Jennifer L. McQuade, MD – The University of Texas MD Anderson Cancer Center

Adjuvant Effects of Obesity on Resident Dendritic Cells
Tim O'Sullivan, PhD – University of California, Los Angeles

(37) MEF2C Regulates NK Cell Effector Functions Through Control of Lipid Metabolism
Joey Li – University of California, Los Angeles

(65) Germline Genetic Variation Shape the Lipid Metabolic & Immune Landscapes of Cancer
Rosalyn W. Sayaman, PhD – University of California, San Francisco

Workshop: Technical Frontiers in Immunometabolism and Tumor Microenvironment
4–6 p.m. ET

Spatial Metabolomics with Cellular Resolution
Nathalie Agar, PhD – Harvard University

Imaging T cell Metabolism with Single-cell Resolution
Melissa Skala, PhD – Morgridge Institute for Research

In situ Tumor Arrays Reveal Environmental Control of Cancer Immunity
Christine Moussion, PhD – Genentech

New Analytical Tools for Deeper Insights into Immune Cell Metabolism and Function
Natalia Romero, PhD – Agilent Technologies, Inc. 

Continuous and Long Term Cell Culture Oxygen Consumption Rate Analysis Utilizing Resipher
Ryan Titmas, MBA – Lucid Scientific, Inc.

Panel Discussion – What's Next?

Session IV:  Metabolism of Adaptive Anti-tumor Immunity
9:05–10:25 a.m. ET

Impact of Tumor Metabolism on the Immune-Vascular Architecture of the Tumor Microenvironment: Implications for Cancer Immunotherapy
Roberta Zappasodi, PhD – Weill Cornell Medicine

Environmental Bottlenecks on T-cell Immunity
Santosha A. Vardhana, MD, PhD – Memorial Sloan Kettering Cancer Center 

(32) Acetyl-CoA Carboxylase Obstructs CD8+ T-cell Lipid Utilization in the Tumor Microenvironment
Elizabeth Hunt – University of North Carolina at Chapel Hill

(36) Mitochondrial Regulator REXO2 is Essential for the Anti-tumor T Cell Immunity
Soundharya Kumaresan, MS – Winship Cancer Institute at Emory University

Session V:  Myeloid Cell Metabolism in the Context of Cancer
10:45 a.m.–12:05 p.m. ET

Targeting Macrophage Lipid Metabolism to Enhance Anti-tumor Responses
Jennifer L. Guerriero, PhD – Brigham and Women’s Hospital 

Innate Immune Control of Tumor Development
Ivan Zanoni, PhD – Harvard Medical School  - Boston Children’s Hospital 

(88) VISTA modulates the metabolic signature of myeloid-derived suppressor cells by regulating polyamine biosynthesis and mitochondrial function
Amin Zakeri, PhD – Cleveland Clinic Foundation

Session VI:  Metabolic Stress in Anti-tumor Immunity
1:25 p.m.–2:45 p.m. ET

Immunometabolic Programs Controlled by ER Stress in Cancer
Juan R. Cubillos-Ruiz, PhD – Weill Cornell Medicine 

Metabolic Polarization of Myeloid Cells in Tumors
Paulo C. Rodriguez, PhD – Moffitt Cancer Center 

(60) Sheltering Telomeres From Oxidative Damage in Therapeutic T Cells Protects Against Tumor-induced Immune Dysfunction
Dayana Rivadeneira, PhD – University of Pittsburgh

(61) Characterization of Myeloid-derived Suppressor Cells in Response to Restraint Stress in Preclinical Models of Ovarian Cancer
Yadiel A. Rivera-Lopez, BS – Ponce Health Sciences University

Workshop: Metabolic Improvements of Cell Therapies
3:10–5:15 p.m. ET 

Immunometabolic Reprogramming of Natural Killer Cells for Immunotherapy of Solid Tumors
Sandro Matosevic, PhD – Purdue University 

Progressively Enhancing Stemness of Adoptive Transferred CD8 T cells with PI3K Delta Blockade Improve Metabolism and Antitumor Immunity
Chrystal M. Paulos, PhD – Winship Cancer Institute at Emory University 

Tools for Bringing Key Metabolite Measurements to the Point of Use in the Development of Cell Therapies
Will Thompson, PhD – 908 Devices 

(27) Redirecting Glucose Flux During in Vitro Expansion Generates Epigenetically & Metabolically Superior T cells for Cancer Immunotherapy
Andrew Frisch, BS – University of Pittsburgh

(29) IL-18-enhanced non-activated CAR T-cells for Improved Metabolic Function & Therapeutic Efficacy
Saba Ghassemi, PhD – Center for Cellular Immunotherapies, Perelman School of Medicine at the University of Pennsylvania

Panel Discussion – What's Next?

Session VII:  Microbiome and Tumor Microenvironment
8:05–9:25 a.m. ET

Understanding Intratumoral Microbes in Human Cancers
Christopher D. Johnston, PhD – Fred Hutchinson Cancer Center 

Presentation Title TBA
Laurence Zitvogel, MD, PhD – Institut Gustave Roussy

Microbes & Their Influence in Remote Tumors Behavior
Florencia McAllister, MD – The University of Texas MD Anderson Cancer Center 

(17) Harnessing Gut Microbiota & Microbial-derived Short-chain Fatty Acids to Improve Combinatorial Chemotherapy/Immunotherapy Efficacy in Triple-negative
Kenysha YJ Clear, BS – Wake Forest University School of Medicine

(47) The Oral Microbiome Can Modulate the Tumor Microenvironment in Metastatic Brain Tumors
Golnaz Morad, DDS, PhD – The University of Texas MD Anderson Cancer Center

Session VIII:  Microbiome Interaction with Immunity in Cancer
9:45–11:05 a.m. ET

Dietary Modifications of Lachnospiraceae Abundance Promotes Response to Immune Checkpoint Blockade
Daniel Spakowicz, PhD – The Ohio State University Medical Center 

Presentation Title TBA
Guido Kroemer, MD, PhD – Institut Gustave Roussy

Sickeningly Sweet: Diet and Microbiome Control of the Tumor Microenvironment
Abby E. Overacre, PhD – University of Pittsburgh

(2) Spatial Profiling Reveals Modulation of the Immune Microenvironment in Rectal Adenocarcinoma by Tumor-Associated Microbes
Reed I. Ayabe, MD – The University of Texas MD Anderson Cancer Center

(16) Microbial Regulation of Anti-tumor Immunity in Metastatic Colorectal Cancer
Charlie Chung – Cold Spring Harbor Laboratory

Session IX:  Translational Relevance: Modulating Cancer and Immune Metabolism in the Clinic
11:25 a.m.–12:45 p.m. ET

Temperature: The Overlooked Factor in the Tumor Microenvironment
Jeffrey C. Rathmell, PhD – Vanderbilt University Medical Center

Microbiome-based Interventions in Oncology Patients
Saman Maleki, PhD – Western University

(19) Window of Opportunity for Durvalumab Plus Metformin Trial for Squamous Cell Carcinoma of the Head & Neck (HNSCC)
Joseph Curry, MD – Thomas Jefferson University

(68) Metabolic, Genetic & Inflammatory Endpoints as Biomarkers of Immune Checkpoint Therapy Efficacy & Immune-Related Adverse Events
David R. Soto-Pantoja, PhD – Wake Forest University School of Medicine