Annual Meeting & Pre-Conference Programs • Schedule

As a benefit for attending the 33rd Annual Meeting & Pre-Conference Programs of the Society for Immunotherapy of Cancer (SITC) provides enduring materials free of charge for the specific programs attended. If you are a SITC member, or member of the general public, but did not register to attend a Pre-Conference program or the 33rd Annual Meeting, the materials are now available by clicking the links below.

Open Access Availability*

  • All materials are open to the public after May 31, 2019.

*Presentations and video recordings are available based on permission from presenters.

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Browse the full schedule by day by clicking the blue tabs below. Also, visit the dedicate landing pages for the Pre-Conference Programs  and 33rd Annual Meeting page to learn more.

Wednesday, Nov. 7

Immune Escape: Current Understanding of Mechanisms and Advances in Therapeutics Approaches

Session I: Therapeutic Strategies to Overcome Immune Resistance

2 p.m.

Introductionno_symbol.pngDaniel S. Chen, MD, PhD – IGM Biosciences

2:05 p.m.

Mechanisms of Immune Escape to Checkpoint Inhibitors
Priti S. Hegde, PhD – Genentech, Inc.

2:25 p.m.

A Novel Inflammasome-Wnt Ligand Signaling Axis Promotes Immune Escape During Anti-PD-1 Antibody Immunotherapy
Brent A. Hanks, MD, PhD – Duke University Medical Center no_symbol.png

2:40 p.m.

Cell Proliferation Defines an Additional Mechanism of Immune Escape in Non-small Cell Lung Cancer
Grace Dy, MD – Roswell Park Comprehensive Cancer Centerno_symbol.png

2:55 p.m.

Melanoma Tissue Microarray Characterization with Digital Spatial Profiling Identifies Biomarkers of Clinical Response to Immunotherapy
David Rimm, MD, PhD – Yale Universityno_symbol.png

3:10 p.m.

Primary and Secondary Mechanisms of Resistance to Autologous Anti-CD19 CAR T cell Therapy in Refractory Non-Hodgkin's Lymphoma (rNHL)
John Rossi, MD – Kite Pharma

3:25 p.m.

Group Discussionno_symbol.png

3:45 p.m.

Break

4 p.m.

Panel Discussion: Can CAR T cells Overcome and Influence Resistance to Other Treatment Modalities & New Concepts in Immune Checkpoint Blockade Designed to Overcome Local Immune Resistance
Co-Moderators:
Adrian Bot, MD, PhD – Kite a Gilead Company
Eric H. Rubin, MD – Merck
Panelists:
Daniel S. Chen, MD, PhD – IGM Biosciences
Gordon J. Freeman, PhD – Dana-Farber Cancer Center
Carl H. June, MD – University of Pennsylvania
Alan Korman, PhD – Bristol-Myers Squibb
Marcela Maus, MD, PhD – Massachusetts General Hospitalno_symbol.png

Session II: Underlying Mechanisms of Immune Escape

5 p.m.

Analysis of TIL from Human Carcinoma Combined with Tissue Imaging and in vitro Models Uncovers Tumor-inflicted T Cell Deviations Related to Immune Escape and Strategies of Intervention
Elfriede Noessner, PhD – Helmholtz Zentrum Munchenno_symbol.png

5:15 p.m.

Impact of Tumor Inherent Interferons on Immune Reactivity and Personalized Therapy in Triple Negative Breast Cancer
Natasha K. Brockwell, BBiomed (Hons) – La Trobe Institute for Molecular Scienceno_symbol.png

5:30 p.m.

Repurposing Anti-Pathogen Vaccines to Overcome Immune Escape within the Tumor Microenvironment
Andrew Zloza, MD, PhD – Rutgers Cancer Institute of New Jerseyno_symbol.png

5:45 p.m.

First in Human Data in Advanced Solid Tumors of NANT Cancer Vaccine: A Novel Temporospatial Orchestration of the Innate (NK) & Adaptive Immune System to Induce Antigen Cascade & Immunogenic Cell Death
Patrick Soon-Shiong – NANT Cancer Immunotherapy, Inc.

6 p.m.

Group Discussionno_symbol.png

6:20 p.m.

Break

6:35 p.m.

Panel Discussion: Immune Resistance and the Tumor Micronenvironment & Using Oncolytic Immunotherapy to Overcome Immune Resistance in the Tumor Microenvironment
Co-Moderators:
Alessandra Cesano, MD, PhD – NanoString Inc.
Howard L. Kaufman, MD, FACS – Replimune Group Inc.
Panelists: Robert Coffin, PhD – Replimune Group Inc.
George Coukos, MD, PhD – University of Lausanne
Francesco M. Marincola, MD – Refuge Biotechnologies
Ira Mellman, PhD – Genentech/Roche
Ryan Sullivan, MD – Massachusetts General Hospital
Dmitriy Zamarin, MD, PhD – Memorial Sloan Kettering Cancer Centerno_symbol.png

7:35 p.m.

Underlying Mechanisms of Immune Escape
Thomas F. Gajewski, MD, PhD – University of Chicagono_symbol.png

Closing

7:55 p.m.

Salil Patel, PhD – Bristol-Myers Squibbno_symbol.png

Immune Escape Reception

8 p.m.

Reception

Thursday, Nov. 8

Workshop on Nutrition, Metabolism and the Microbiome in Cancer Therapy

Introduction

8 a.m.

Laurence Zitvogel, MD, PhD – Institute Gustave Roussyno_symbol.png

Session I: The Impact of the Microbiome on Cancer Therapy

8:05 a.m. The Evolving Role of the Microbiome on Response to Cancer Therapy
Laurence Zitvogel, MD, PhD – Institute Gustave Roussyno_symbol.png

8:30 a.m. Mechanistic Insights Into the Influence of Gut Microbiota on Anti-Tumor Immunity
Thomas F. Gajewski, MD, PhD – University of Chicagono_symbol.png

9:00 a.m. The Microbiome as a Biomarker and a Therapeutic Target
Jennifer A. Wargo, MD, MMSc – University of Texas MD Anderson Cancer Center

9:30 a.m. Panel Discussion
Moderator: 
Laurence Zitvogel, MD, PhD – Institute Gustave Roussy
Panelists: Jennifer A. Wargo, MD, MMSc – University of Texas MD Anderson Cancer Center
Thomas F. Gajewski, MD, PhD – University of Chicagono_symbol.png

9:45 a.m.

Break

Session II: Interplay of Nutrition, Metabolism, and the Microbiome

10:00 a.m. The Influence of Nutrition on the Microbiome and Immune Function
Guido Kroemer, MD, PhD – Institute Gustave Roussyno_symbol.png
10:30 a.m.

Harnessing Diet and the Microbiome for Cancer Patients and Survivors
Carrie Daniel-MacDougall, MPH, PhD – University of Texas MD Anderson Cancer Centerno_symbol.png

11:00 a.m.

Homeostatic and Inflammatory Immune Responses to Human Microbiotas in Gnotobiotic Mice
Graham Britton, PhD – Icahn School of Medicine at Mount Sinai


11:30 a.m.

The Interplay Between Diet, Intestinal Microbiota and Colorectal Cancer
Christian Jobin, PhD – University of Floridano_symbol.png

Panel Discussion

Noon Moderator: Laurence Zitvogel, MD, PhD – Institute Gustave Roussy
Panelists:
Thomas F. Gajewski, MD, PhD – University of Chicago
Jennifer Wargo, MD, MMSc – University of Texas MD Anderson Cancer Center
Guido Kroemer, MD, PhD – Institute Gustave Roussy
Carrie Daniel-MacDougall, PhD – University of Texas MD Anderson Cancer Center
Christian Jobin, PhD – University of Florida
Graham Britton, PhD – Icahn School of Medicine at Mount Sinaino_symbol.png

Primer on Tumor Immunology and Cancer Immunotherapy™

Introduction

8 a.m.

Jonathan Powell, MD, PhD – Johns Hopkins University School of Medicine no_symbol.png

Session I: Generating Anti-Tumor Immunity

8:05 a.m. Adaptive Immunity to Tumors: Laying the Foundation for Immunotherapy

Jonathan Powell, MD, PhD – Johns Hopkins University School of Medicine


8:35 a.m. Dendritic Cells
Tyler Curiel, MD – UT Health San Antonio

9:05 a.m. Harnessing Natural Killer Cells to Potentiate Antitumor Immunity
Amir Horowitz, PhD – Icahn School of Medicine at Mount Sinai

9:35 a.m. Panel Discussionno_symbol.png

9:55 a.m.

Break

Session II: Breaking Through the Barriers - Passive Immunotherapy

10:10 a.m. Introduction
Timothy NJ Bullock, PhD – University of Virginiano_symbol.png
10:15 a.m.

Cancer Vaccines : From Ex Vivo Production to In Vivo Vaccination
Tanja de Gruijl, PhD – VU University Medical Center


10:45 a.m. Monoclonal Antibodies and Their Derivatives
Charles G. Drake, MD, PhD – Columbia Universityno_symbol.png
11:15 a.m. Cytokines in Cancer: Biology and Therapy
Kim A. Margolin, MD – City of Hope

11:45 a.m. Panel Discussion

Session III: Analysis of Resistance and Response

1:05 p.m. Introduction
Jonathan Powell, MD, PhD – Johns Hopkins University School of Medicineno_symbol.png
1:10 p.m. Mechanisms of Extrinsic Resistance : A Miserable Microenvironment
Michael A. Curran, PhD – University of Texas MD Anderson Cancer Center

1:40 p.m. Mechanisms of Resistance: Checkpoint Receptors
Julie R. Brahmer, MD – Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins

2:10 p.m. A High-dimensional Assay and Analysis Platform to Discover Immune Correlates of Cancer Immunotherapy
Sacha Gnjatic, PhD – Icahn School of Medicine at Mount Sinaino_symbol.png
2:40 p.m. Panel Discussionno_symbol.png

3:10 p.m.

Break

Session IV: Current IO Immunotherapy

3:25 p.m. Introduction
Jonathan Powell, MD, PhD – Johns Hopkins University School of Medicineno_symbol.png
3:30 p.m. Adoptive T Cell Therapy
Patrick Hwu, MD – University of Texas MD Anderson Cancer Center

4 p.m. Combination Therapies
Leisha Emens, MD, PhD – University of Pittsburghno_symbol.png
4:30 p.m. Panel Discussionno_symbol.png
4:50 p.m. Closing
Jonathan Powell, MD, PhD – Johns Hopkins University School of Medicineno_symbol.png

Thursday, Nov. 8

Immune-modified Response Criteria in Cancer Immunotherapy Clinical Trials Workshop

Introduction

2 p.m.

Marc Theoret, MD – U.S. Food & Drug Administration, OHOP
Howard Kaufman, MD, FACS – Replimune Group, Inc.no_symbol.png

Session I

Pseudoprogression with Immuno-oncology Therapeutics - Current Challenges with Evaluation

2:10 p.m. Pseudoprogression and Current Clinical Challenges in the Management of Patients on Immuno-Oncology Therapy 
Kim Margolin, MD – City of Hope

2:30 p.m. Immune-Modified Response Criteria in Clinical Development Programs of Immuno-Oncology Therapeutics
Sanjay Goel, MD – Montefiore Medical Center

2:50 p.m. Regulatory Perspectives with Use of Immune-modified Response Criteria for Assessment of Surrogate Clinical Efficacy Endpoints for Registration Trials
Patricia Keegan, MD – U.S. Food and Drug Administrationno_symbol.png
3:10 p.m. Panel Discussion

Moderator: Marc Theoret, MD – U.S. Food & Drug Administration, OHOP 
Panelists: Peter Bross, MD – U.S. Food & Drug Administration, CBER, DCEPT
David Feltquate, MD, PhD – Bristol Myers Squibb
Sanjay Goel, MD – Montefiore Medical Center
Patricia Keegan, MD – U.S. Food and Drug Administration
Kim Margolin, MD – City of Hope
Steven Silverstein, MBA – Melanoma Research Foundation
Jon Wigginton, MD – MacroGenics, Inc.no_symbol.png

3:55 p.m.

Break

Session II

Evaluating Surrogate Endpoints for IO Drug Development: “New and renewed” Concepts and Perspectives

4:10 p.m. Clinical Trial Endpoints Considerations for Evaluating Efficacy in Immuno-Oncology Clinical Trials
David McDermott, MD – Beth Israel Deaconess Medical Center

4:30 p.m. Beyond Conventional Tumor-Based Measurements: Analysis Considerations for Clinical Efficacy Endpoints to More Fully Capture the Benefit of IO Therapeutics
Rajeshwari Sridhara, PhD – U.S. Food & Drug Administrationno_symbol.png
4:50 p.m. How to Integrate Biomarkers and Other Correlates of Response Into the Regulatory Landscape

Genevieve Boland, MD, PhD – Massachusetts General Hospitalno_symbol.png

5:10 p.m. Panel Discussion

Moderator: Howard Kaufman, MD, FACS – Replimune Group Inc.
Panelists: Genevieve Boland, MD, PhD – Massachusetts General Hospital
Samir Khleif, MD – Georgetown University
Ke Liu, MD, PhD – U.S. Food and Drug Administration, CBER
David McDermott, MD – Beth Israel Deaconess Medical Center
Reena Philip, PhD – U.S. Food & Drug Administration
Meredith Regan, ScD – Dana-Farber Cancer Institute
Lawrence H. Schwartz, MD – Columbia University College of Physicians and Surgeons
Rajeshwari Sridhara, PhD – U.S. Food & Drug Administrationno_symbol.png

5:55 p.m. Closing

Michael B. Atkins, MD – Georgetown-Lombardi Comprehensive Cancer Center
Ke Liu, MD, PhD – Food and Drug Administration, CBERno_symbol.png

Grant Writing: From Start to Finish, and Then Starting Again

Introduction

6:30 p.m. Jennifer Guerriero, PhD – Dana-Farber Cancer Institute

Session Schedule

6:35 p.m. Obtaining Funding in Academia - Identifying and Selecting the Appropriate Grant 
Pawel Kalinski, MD, PhD – Roswell Park

6:55 p.m. Obtaining Funding in Academia - Mechanics of Grant Writing
Thomas Gajewski, MD, PhD – University of Chicagono_symbol.png
7:15 p.m. NIH/NCI Grants: The NIH Grant Review Process
Denise  R. Shaw, PhD – National Institutes of Health

7:35 p.m.

Melanoma Research Alliance (MRA)/Foundation Funding
Kristen Mueller, PhD – Melanoma Research Alliance


7:55 p.m. Panel Discussion
Moderator:
Lorenzo Falchi, MD – Columbia University Medical Centerno_symbol.png
8:25 p.m. Closing
Ana Carrizosa Anderson, PhD – Harvard Medical Schoolno_symbol.png

Friday, Nov. 9

Annual Meeting

7:15 a.m.

Presidential Champagne Toast & Membership Business Meeting

Presidential Welcome

8 a.m.

Lisa Butterfield, PhD – University of Pittsburghno_symbol.png

Session 100: FDA & SU2C Update Session

8:05 a.m.

Food & Drug Administration Update: Cell and Gene Therapy
Raj Puri, MD, PhD – Food & Drug Administration

8:20 a.m.

Stand Up To Cancer Update
Carl H. June – University of Pennsylvaniano_symbol.png

Session 101: Keynote Address

8:35 a.m.

Introduction
Lisa H. Butterfield – University of Pittsburghno_symbol.png

8:40 a.m.

Next Gen T Cell-based Immunotherapy
Nicholas Restifo, MD – National Cancer Instituteno_symbol.png

Session 102: Understanding the Tumor Microenvironment

Co-Chairs:

Bernard A. Fox, PhD – Earle A. Chiles Research Institute, Robert W. Franz Cancer Center
Stefani Spranger, PhD – Koch Institute for Integrative Cancer Research at MIT

9:25 a.m.

Introduction
Bernard A. Fox, PhD – Earle A. Chiles Research Institute, Robert W. Franz Cancer Centerno_symbol.png

9:30 a.m.

Genomic Approaches to the Tumor Microenvironment
Alexandra Snyder Charen, MD Merck

9:50 a.m.

Understanding the Tumor Immune Composition Using Quantitative and Spatially Resolved Imaging Mass Cytometry
Kurt A. Schalper, MD, PhD Yale School of Medicineno_symbol.png

10:10 a.m.

Break

10:25 a.m.

Single Cell Genomics – Using a Finer Lens to Unravel Features of Human Immunity
Alexandra-Chloe Villani, PhD – Massachusetts General Hospital

10:45 a.m.

Mouse Models of the TME
Tyler Jacks, PhD – Koch Institute for Integrative Cancer Research at MITno_symbol.png

11:05 a.m.

Reinvigorating TILs by hyper-oxygenation
Tomasz Zal, PhD – MD Anderson Cancer Centerno_symbol.png

11:20 a.m.

Comparison of biomarker assay modalities in anti-PD-(L)1 monotherapy: a meta-analysis
Steve Lu, BS – John Hopkins University School of Medicineno_symbol.png

11:35 a.m.

Panel Discussionno_symbol.png

11:55 a.m.

Closing
Stefani Spranger, PhD – Koch Institute for Integrative Cancer Research at MITno_symbol.png

Session 103: Late-Breaking Abstract Session

Late-Breaking Abstract Session
Chair: Crystal Mackall, MD – Stanford University

Noon

Imaging of tumor infiltrating T cells with an anti-CD8 minibody 89Zr-IAB22M2C in advanced solid tumors: a phase I first-in-human study
Michael Gordon, MD – HonorHealth Research Instituteno_symbol.png

12:15 p.m.

In silico assessment of variation in TMB quantification across diagnostic platforms: Phase 1 of the Friends of Cancer Research Harmonization Project
David Fabrizio, PhD – Foundation Medicineno_symbol.png

12:30 p.m.

Team TimIOs – A Pooled Analysis of Durable versus Transient Responders on Immunotherapy Trials
Yana Najjar, MD – University of Pittsburgh
Randy Sweis, MD – University of Chicago

12:45 p.m.

Lunch; Poster Viewing & Exhibits

Rapid Oral Abstract Presentations

Co-Chairs:
Sebastiano Battaglia, PhD – Roswell Park Comprehensive Cancer Institute
Claire Vanpouille-Box, PhD – Weill Cornell Medical College

1 p.m.

High-dimensional flow cytometry of circulating immune cells predicts clinical responses to combination Immune Checkpoint Blockade (ICB) and Radiotherapy (RT) in Gastroesophageal Cancer (GEC)
Joseph Chao, MD – City of Hope Comprehensive Cancer Center

1:05 p.m.

Fast quality gauging of tumor-infiltrating lymphocytes (TIL) for the treatment of patients with solid cancer
Georgia Paraschoudi, M.Sc. – Champalimaud Foundationno_symbol.png

1:10 p.m.

Immunologic biomarkers in a multi-center, single arm, open label Phase II clinical trial of mFOLFOX6 and pembrolizumab in patients with advanced colorectal cancer
Matthew Farren, PhD – Emory University

1:15 p.m.

Deep learning of the immune synapse
John- William Sidhom, MSE – John Hopkins University

1:20 p.m.

Overcoming genetically-based resistance mechanisms to PD-1 blockade
Davis Torrejon, MD – UCLA Hematology-Oncology

1:25 p.m.

Fecal microbiota transplantation for refractory immune checkpoint inhibitor-associated colitis
Yinghong Wang, MD, PhD –  University of Texas MD Anderson Cancer Center

1:30 p.m.

Using high dimensional mass cytometry (CyTOF) and machine assisted analysis to detect biomarkers in the immunotherapy of cancer
Carsten Krieg, PhD – Medical University of South Carolinano_symbol.png

1:35 p.m.

Development of a next-generation sequencing-based microsatellite instability assay (MSI-NGS) for solid tumor testing
Sean Glenn, PhD – Omniseq, Inc.

1:40 p.m.

Molecular profiling of anti-PD-1 treated melanoma patients reveals importance of assessing neoantigen burden and tumor escape mechanisms for clinical treatment
Sekwon Jang, MD – iNova/Personalisno_symbol.png

1:45 p.m.

Preinfusino product doubling time is associated with CAR T cell expansion and outcomes in zumit-1, the pivotal study of axicabtagene cildeneel (axi-ced) in refractory large B cell lymphoma
Frederick Locke, MD - H. Lee Moffitt Cancer Center and Research Institute no_symbol.png

1:50 p.m.

SIRPα blockade increases the activity of multiple myeloid lineage cells, enhances dendritic cell cross-presentation, and aids in remodeling the tumor microenvironment
Jay Hyok Chung – Aduro Biotechno_symbol.png

1:55 p.m.

DuoBody-PD-L1x4-1BB combines checkpoint blockade and 4-1BB co-stimulation to promote antigen-specific T-cell stimulation and proliferation
Isil Altintas, PhD – Genmabno_symbol.png

2:00 p.m.

Molecular determinants of response to PD-L1 blockade across tumor types
Romain Banchereau – Genentechno_symbol.png

2:05 p.m.

CYAD-101: an allogeneic NKG2D CAR T cell therapy using a TCR inhibitory molecule
Alexandre E. Michaux, PhD – Celyad SAno_symbol.png

Concurrent Session 104: Immune Checkpoints – Beyond PD-1

Co-Chairs:

Ana Carrizosa Anderson, PhD – Harvard Medical School
Charles G. Drake, MD, PhD – Columbia University Medical Center

2:15 p.m.

Introduction
Ana Carrizosa Anderson, PhD – Harvard Medical Schoolno_symbol.png

2:20 p.m.

LAG-3: Signaling, Function and Potential Impact on Cancer Immunotherapy
Dario A.A. Vignali University of Pittsburghno_symbol.png

2:45 p.m.

Regulation of Dendritic Cell Function by TIM-3
Brian Ruffell, PhD Moffitt Cancer Centerno_symbol.png

3:10 p.m.

Break

3:25 p.m.

Targeting the TIGIT/CD226 Axis in Cancer Immunotherapy
Hassane M. Zarour, MD UPMC Hillman Cancer Centerno_symbol.png

3:50 p.m.

4-1BB and Metabolism
Ignacio Melero, MD, PhD Clinica Universidad de Navarra-FIMAno_symbol.png

4:15 p.m.

Remodeling the tumor microenvironment – Targeting Scavenger receptors
Dhifaf Sarhan, PhD – Karolinska Institutetno_symbol.png

4:30 p.m.

Resistance to PD1 blockade in the absence of metalloprotease-mediated LAG3 shedding
Lawrence P. Andrews, PhD – University of Pittsburghno_symbol.png

4:45 p.m.

Closing
Charles G. Drake, MD, PhD – Columbia University Medical Centerno_symbol.png

Concurrent Session 105: Early Phase 1 Clinical Trials

Co-Chairs:

David S. Hong, MD – University of Texas MD Anderson Cancer Center
Patricia LoRusso, DO – Yale University

2:15 p.m.

Introduction
David S. Hong, MD – University of Texas MD Anderson Cancer Center

2:20 p.m.

Phase 1 study using mogamulizumab (KW-0761) to deplete regulatory T cells in combination with checkpoint inhibitors durvalumab (MEDI4736) or tremelimumab in subjects with advanced solid tumors
Dmitriy Zamarin, MD, PhD – Memorial Sloan Kettering Cancer Center

2:35 p.m.

First-in-human phase 1 dose-escalation trial of the potent and selective next generation transforming growth factor-β receptor type 1 (TGF-βR1) inhibitor LY3200882 in patients with advanced cancers
Timothy Yap, MD – University of Texas MD Anderson Cancer Center

2:50 p.m.

Expert Discussant
Zihai Li, MD, PhD – MUSC Hollings Cancer Centerno_symbol.png

3:00 p.m.

The GAPVAC approach of actively personalized peptide vaccination for patients with newly diagnosed glioblastoma
Hideho Okada, MD, PhD – University of California, San Francisco, USA and Parker Institute for Cancer Immunotherapy

3:15 p.m.

The Personal Vaccine, NEO-PV-01 with anti-PD1, Induces Neoantigen-Specific De Novo Tumor-Related Immunity in Patients with Advanced Cancer
Siwen Hu-Lieskovan, MD, PhD – Ronald Reagan UCLA Medical Centerno_symbol.png

3:30 p.m.

Expert Discussant
Drew Pardoll, MD, PhD – Johns Hopkins Universityno_symbol.png

3:40 p.m.

A phase 1 study of TSR-022, an anti-TIM-3 monoclonal antibody, in combination with TSR-042 (anti-PD-1) in patients with colorectal cancer and post-PD-1 NSCLC and melanoma
Diwakar Davar, MD – University of Pittsburgh Department of Medicine

3:55 p.m.

Results from a Phase I dose escalation trial (TACTI-mel) with the soluble LAG-3 protein (IMP321, eftilagimod alpha) together with pembrolizumab in unresectable or metastatic melanoma
Adnam Khattak, MD – Perth University

4:10 p.m.

The anti–LAG-3 antibody MK-4280 as monotherapy and in combination with pembrolizumab for advanced solid tumors: first-in-human phase 1 dose-finding study
Nehal Lakhani, MD, PhD – START-Midwest

4:25 p.m.

Phase 1 dose-finding study of the anti–TIGIT antibody MK-7684 as monotherapy and in combination with pembrolizumab in patients with advanced solid tumors
Talia Golan – Sheba Medical Center

4:40 p.m.

Expert Discussant
Aung Naing, MD, FACP – University of Texas MD Anderson Cancer Center

4:50 p.m.

Break

Concurrent Session 106: Cytokines Reinvented

Co-Chairs:

James L. Gulley, MD, PhD, FACP – National Cancer Institute
Darrell J. Irvine, PhD – Massachusetts Institute of Technology

5:05 p.m.

Introduction
James L. Gulley, MD, PhD, FACP – National Cancer Institute

5:07 p.m.

NHS/IL15
Marijo Bilusic, MD, PhD National Cancer Institute, National Institutes of Health

5:27 p.m.

Harnessing Potent Immune Agonist Pathways through Kinetic Engineering
Deborah Charych, PhD

5:47 p.m.

Locoregional Cytokine Immunotherapy
K. Dane Wittrup, PhD Massachusetts Institute of Technology

6:07 p.m.

Immune monitoring after NKTR-214 plus nivolumab (PIVOT-02) in previously untreated patients with metastatic Stage IV melanoma
Adi Diab, MD – The University of Texas MD Anderson Cancer Center

6:17 p.m.

Decoy-resistant Interleukin-18 overcomes the soluble immune checkpoint IL-18BP to unlock a potent immunotherapeutic cytokine pathway
Aaron Ring – Yale School of Medicine

6:27 p.m.

Closing
Darrell J. Irvine, PhD – Massachusetts Institute of Technologyno_symbol.png

Concurrent Session 107: Metabolic Manipulation of the TME

Co-Chairs:

Greg M. Delgoffe, PhD – University of Pittsburgh
Michele W. Teng, PhD – QIMR Berghofer Medical Research Institute

5:05 p.m.

Targeting the Adenosinergic Pathway to Improve Combination Immunotherapy
Michele W. Teng, PhD – QIMR Berghofer Medical Research Instituteno_symbol.png

5:25 p.m.

Enhancement of Oncolytic Virus Immunotherapy Through Vector-Encoded Metabolic Modulation of the Tumor Microenvironment
Greg M. Delgoffe, PhD – University of Pittsburghno_symbol.png

5:45 p.m.

Chronic endoplasmic reticulum stress drives mitochondrial exhaustion of CD8 TILs
Jessica Thaxton, PhD MSCR – Medical University of South Carolina

6:00 p.m.

Suppression of Myeloid Cell Arginase Activity leads to Therapeutic Response in a NSCLC Mouse Model by Activating Anti-Tumor Immunity
Esra Akbay, PhD – University of Texas Southwestern Medicalno_symbol.png

6:15 p.m.

Tumor cell oxidative metabolism as a barrier to PD-1 blockade immunotherapy in melanoma
Ashley Menk, BS – University of Pittsburghno_symbol.png

6:30 p.m.

Poster Reception

Saturday, Nov. 10

Annual Meeting

7:20 a.m.

Annual Meeting Organizer Welcome
Krista M. Rubin, MS, FNP-BC – Massachusetts General Hospital

Session 200: Policy Committee Update Session

7:25 a.m.

Policy Committee Update
Samir N. Khleif, MD Georgetown Universityno_symbol.png

Session 201: Smalley Keynote

7:40 a.m.

Introduction
Lisa Butterfield, PhD – University of Pittsburghno_symbol.png

7:45 a.m.

Engineering T cells to Effectively Target Tumors and Overcome Obstacles To Achieving Tumor Eradication
Philip D. Greenberg, MD – Fred Hutchinson Cancer Research Center
no_symbol.png

Session 202: Cell-Based Therapies for Solid Tumors

Co-Chairs:

Chantale Bernatchez, PhD – University of Texas MD Anderson Cancer Center 
Mitchell Cairo, MD – New York Medical College at Maria Fareri Children's Hospital   
Crystal L. Mackall, MD – Stanford University

8:30 a.m.

Introduction
Crystal Mackall, MD – Stanford Universityno_symbol.png

8:35 a.m.

Pre-Clinical Approaches to CAR NK cell Therapy in Neuroblastoma and Sarcomas
Mitchell Cairo, MD – New York Medical College at Maria Fareri Children's Hospital   no_symbol.png

8:55 a.m.

CAR T cell Therapies in Glioblastoma
Christine Brown, PhD – City of Hope National Medical Centerno_symbol.png

9:15 a.m.

Break

9:30 a.m.

CAR T Cell Therapies in Solid Tumors
Gianpietro Dotti, MD – University of North Carolina, Chapel Hillno_symbol.png

9:50 a.m.

TIL Therapy for Melanoma and Beyond - Lessons Learned on Optimal Tumor Rejection Antigens for Solid Tumors
Steven A. Rosenberg, MD, PhD – National Cancer Institute, National Institutes of Healthno_symbol.png

10:10 a.m.

Tscm-like CD8+ T-cells are Associated with Adoptive TIL Therapy Response and Survival
Matthew Beatty, PhD – Moffitt Cancer Centerno_symbol.png

10:25 a.m.

Next-generation retroviral vector with membrane-anchored IL-12 to improve adoptive T cell immunotherapy and enhance its safety
Ling Zhang, PhD – National Institutes of Healthno_symbol.png

10:40 a.m.

Panel Discussionno_symbol.png

11:00 a.m.

Closing
Chantale Bernatchez, PhD – University of Texas MD Anderson Cancer Centerno_symbol.png


Organized in collaboration with the International Society for Cellular Therapy (ISCT).

Concurrent Session 203: National Cancer Institute Update Session

11:05 a.m.

National Cancer Institute Update: Immuno-oncology Research at the National Cancer Institute
Norman E. Sharpless, MD – National Cancer Instituteno_symbol.png

Concurrent Session 204: Clinical Management of Cell Therapy Administration

Co-Chairs:

Harriet Kluger, MD – Yale University
Krista M. Rubin, MS, FNP-BC – Massachusetts General Hospital  

11:05 a.m.

Introduction
Harriet Kluger, MD – Yale University
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11:10 a.m. Tumor Infiltrating Lymphocytes
Ronnie Shapira, MD -Frommer, MD – Ella Institute for Immuno-Oncologyno_symbol.png
11:30 a.m.

Clinical and Biomarker Correlates and Management of Common Cellular Therapy Toxicities Including Cytokine Release Syndrome and Neurotoxicity
Eric L. Smith, MD, PhD – Memorial Sloan Kettering Cancer Centerno_symbol.png

11:50 a.m. CAR T Cell Therapy and Cell Therapy in Pediatric Cancer Treatment
Shannon L. Maude, MD, PhD – Children's Hospital of Philadelphia Center for Childhood Cancer Researchno_symbol.png
12:10 p.m. Q&Ano_symbol.png
12:25 p.m. Closing
Krista Rubin, MS, FNP-BC – Massachusetts General Hospitalno_symbol.png

Session 205: Late-Breaking Abstract Session

Chair: Naiyer A. Rizvi, MD – Columbia University Medical Center

11:35 a.m.

Pembrolizumab in combination with chemoradiotherapy (CRT) in human papilloma virus (HPV)-associated head and neck squamous cell carcinoma (HNSCC)
Steven F. Powell, MD – Sanford Cancer Center

11:50 a.m.

Expert Discussant
Charles Drake, MD, PhD – Columbia University Medical Centerno_symbol.png

Concurrent Session 206: SITC Sparkathon Update

12:05 p.m.

Team METIOR Incubator: Strengthening Communication Across Scientific Disciplines
Alexandra Cadena, BS/BA – MD Anderson Cancer Center
Sebastiano Battaglia – Roswell Park Cancer Institute

Rapid Oral Abstract Presentations

Chair:
Julie Decock, PhD – Qatar Biomedical Research Institute

12:35 p.m.

Pharmacodynamic Activity of MEDI1873, a Glucocorticoid-Induced Tumor Necrosis Factor Family-Related protein (GITR) Agonist Molecule, Administered Intravenously to Patients with Advanced Solid Tumors
Nicholas Durham, PhD – MedImmune

12:40 p.m.

Intratumoral injection of a novel oncolytic virus, Voyager V1 (VV1): completed phase 1 monotherapy in patients with refractory solid tumors
Steven Powell, MD – Sanford Cancer Center

12:45 pm.

First-in-human phase 1 study of IT1208, a defucosylated humanized anti-CD4 depleting antibody, in patients with advanced solid tumors
Kohei Shitara, MD – National Cancer Hospital East

12:50 p.m.

Initial results from a phase 1a/b study of etigilimab (OMP-313M32), an anti-T cell immunoreceptor with Ig and ITIM domains (TIGIT) antibody, in advanced solid tumors
Sunil Sharma, MD – Honor Health Research Institute

12:55 p.m.

A phase 1 study of ALX148: CD47 blockade in combination with anticancer antibodies to bridge innate and adaptive immune responses for advanced malignancy
Nehal Lakhani, MD, PhD – START Midwest

1 p.m.

Phase I dose-finding study of MIW815 (ADU-S100), an intratumoral STING agonist, in patients with advanced solid tumors or lymphomas
Funda Meric-Bernstam, MD – MD Anderson Cancer Center

1:05 p.m.

Preliminary evidence of intratumoral activation and immunomodulatory effect of CX-072, a Probody therapeutic antibody prodrug targeting PD-L1, in a phase 1/2a trial
Luc R. Desnoyers, PhD – CytomX Therapeutics, Inc.no_symbol.png

1:10 p.m.

Preliminary Biomarker Analysis of Sitravatinib in Combination with Nivolumab in NSCLC Patients Progressing on Prior Checkpoint Inhibitor
Kai He, MD, PhD

1:15 p.m.

A phase 1b/2 trial of lenvatinib in combination with pembrolizumab in patients with non-small cell lung cancer
Marcia Brose – Abramson Cancer Center of the University

1:20 p.m.

HyPeR: A Phase 1, Dose Escalation Study of Guadecitabine (SGI-110) a Second Generation HypoMethylating Agent in Combination with Pembrolizumab (MK3475) in Patients with Refractory Solid Tumours
Malaka Ameratunga, MBBS – Royal Marsden Hospitalno_symbol.png

1:25 p.m.

Interleukin-6 gene expression is highly upregulated in immune checkpoint mediated enterocolitis
Daniel Johnson, MD – MD Anderson Cancer Center

1:30 p.m.

Clinical efficacy of immune checkpoint inhibitors in patients with small cell lung cancer is associated with high tumor mutational burden and development of immune-related adverse events
Biagio Ricciuti, MD – Dana-Farber Cancer Institute

12:20 p.m.

Lunch; Poster Viewing & Exhibiting

Session 207: Presidential Session

1:55 p.m.

Introduction
Lisa H. Butterfield, PhD – University of Pittsburgh

2 p.m.

PAK4 inhibition reverses immune cell exclusion and overcomes resistance to checkpoint blockade therapy
Gabriel Abril-Rodriguez, MS – University of California, Los Angeles

2:15 p.m.

Adaptive plasticity of IL10+ and IL35+ regulatory T cells and their cooperative regulation of anti-tumor immunity
Hiroshi Yano, BS – University of Pittsburghno_symbol.png

2:30 p.m.

Expert Discussant
Nicholas P. Restifo, MD – National Cancer Instituteno_symbol.png

2:40 p.m.

Endoplasmic reticulum stress-induced transcription factor C/EBP homologous protein (Chop) thwarts effector T cell activity in tumors through repression of T-bet
Yu Cao, PhD – H. Lee Moffitt Cancer Center & Research Instituteno_symbol.png

2:55 p.m.

Engineering adoptive T cell therapy to co-opt Fas ligand-mediated death signaling in solid tumors
Kristin Anderson, PhD – Fred Hutchinson Cancer Research Centerno_symbol.png

3:10 p.m.

Expert Discussant
Patrick Hwu, MD - University of Texas MD Anderson Cancer Center

3:20 p.m.

Break

Concurrent Session 208: Advances in Immunotherapy of Breast and Gynecologic Cancers

Co-Chairs:

George Plitas, MD – Memorial Sloan Kettering Cancer Center
Alessandro Santin, MD – Yale School of Medicine

3:35 p.m.

Introduction
George Plitas, MD – Memorial Sloan Kettering Cancer Center     

3:40 p.m.

Advances in Immunotherapy of Gynecologic Malignancies
Dmitrity Zamarin, MD, PhD – Memorial Sloan Kettering Cancer Center


4:05 p.m. Breast Cancer
Sylvia Adams, MD – New York University Cancer Instituteno_symbol.png
4:30 p.m.

Increased tumor-resident memory T cells in breast cancer is associated with improved prognosis
Paul Neeson, PhD – Peter MacCallum Cancer Centreno_symbol.png

4:45 p.m.

Tumor infiltrating lymphocyte recruitment after peri-lymphatic IRX-2 cytokine immunotherapy in resectable breast cancer and head and neck carcinoma
David Page, MD – Providence Portland Medical Center

Concurrent Session 209: Advances in Immunotherapy of GI and Pancreatic Cancer

Co-Chairs:

Dung T. Le, MD – The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins University
Herbert J. Zeh, MD – University of Pittsburgh Medical Center

3:35 p.m.

Introduction
Dung T. Le, MD – The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins University

3:40 p.m. Augmenting T cell Immunity in Pancreatic Cancer
Stephanie K. Dougan, PhD – Dana-Farber Cancer Instituteno_symbol.png
3:55 p.m.

Reprograming the Pancreatic Tumor Microenvironment to Improve Responses to Therapy
David G. DeNardo, PhD – Washington University


4:10 p.m.

Exploiting the Complex Stromal Biology of Pancreas Cancer
Sunil R. Hingorani, MD, PhD – Fred Hutchinson Cancer Research Centerno_symbol.png

4:25 p.m. Immunotherapy in Hepatocellular Carincoma (HCC)
Kevin Staveley-O'Carroll, MD, PhD, MBA – University of Missourino_symbol.png
4:40 p.m.

Lipid accumulation in the pancreatic tumor microenvironment drives metabolic exhaustion of CD8+ T cells
Teresa Manzo, PhD – European Institute of Oncology, Milanno_symbol.png

4:55 p.m. Closing
Herbert J. Zeh, MD – UT Southwestern Medical Center 

Concurrent Session 210: Advances in Immunotherapy of GU Tumors

Co-Chairs:

Arjun V. Balar, MD – Perlmutter Cancer Center - New York University Langone Medical Center
Padmanee Sharma, MD, PhD – University of Texas MD Anderson Cancer Center 

3:35 p.m. Introduction
Arjun V. Balar, MD – Perlmutter Cancer Center – New York University Langone Medical Centerno_symbol.png
3:40 p.m.

The Management of Urothelial Bladder Cancer in the Era of Cancer Immunotherapy
Arjun V. Balar, MD – Perlmutter Cancer Center - New York University Langone Medical Center


4:00 p.m.

Clinical Genomics and Cancer Immunotherapy
Eliezer Van Allen, MD – Dana-Farber Cancer Institute


4:20 p.m.

From the Clinic to the Lab: Investigating Response and Resistance Mechanisms to Immune Checkpoint Therapy
Padmanee Sharma, MD, PhD – University of Texas MD Anderson Cancer Centerno_symbol.png

4:40 p.m.

Refractory renal cell cancer (RCC) exhibits high adenosine A2A receptor (A2AR) expression and prolonged survival following treatment with the A2AR antagonist, CPI-444
Lawrence Fong, MD – University of California

4:55 p.m. Closing
Padmanee Sharma, MD, PhD – University of Texas MD Anderson Cancer Center  no_symbol.png

Concurrent Session 211: Advances in Immunotherapy of Hematologic Malignancies

Co-Chairs:

Joshua Brody, MD – Mount Sinai School of Medicine
Elizabeth Shpall, MD – University of Texas MD Anderson Cancer Center

3:35 p.m.

Off-The-Shelf Engineered NK Cells for The Treatment of Cancer
Katayoun Rezvani, MD, PhD – University of Texas MD Anderson Cancer Centerno_symbol.png

4:00 p.m. CAR T cells
Stanley R. Riddell, MD – Fred Hutchinson Cancer Research Centerno_symbol.png
4:25 p.m. Checkpoint Blockade
Thomas Marron, PhD – Mount Sinai Hospital

4:45 p.m.

LSD1 Inhibition Promotes CD141Hi Dendritic Cell Differentiation in Myelodysplastic Syndromes
Pragya Srivastava, PhD – Roswell Park Comprehensive Cancer Centerno_symbol.png

Organized in collaboration with the American Society of Blood and Marrow Transplant (ASBMT).

Concurrent Session 212: Advances in Immunotherapy of Lung, Head and Neck Cancer

Co-Chairs:

Naiyer A. Rizvi, MD – Columbia University Medical Center
Tanguy Seiwert, MD – University of Chicago

3:35 – 3:40 p.m.

Introduction
Naiyer A. Rizvi, MD – Columbia University Medical Centerno_symbol.png

3:40 – 4:05 p.m.

The Influence of the Cancer Genome on Efficacy of Immunotherapy in Lung Cance
Nadeem Riaz, MD, MSc – Memorial Sloan Kettering Cancer Center

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4:05  4:30 p.m. Head and Neck Cancer
Tanguy Seiwert, MD – University of Chicago
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4:30 - 4:45 p.m.

Identification and profiling of neoantigen-specific T cells in NSCL cancer patients treated with atezolizumab
Alessandra Nardin, DVM – immunoSCAPEno_symbol.png

4:45 – 5 p.m.

Peripheral T cell dynamics in resectable NSCLC patients treated with neoadjuvant PD-1 blockade
Jiajia Zhang, MD – MPH – Johns Hopkins University

Concurrent Session 213: Advances in Immunotherapy of Pediatric Malignancies

Co-Chairs:

Kavita M. Dhodapkar, MD – Emory University
Crystal L. Mackall, MD – Stanford University

3:35 p.m.

Introduction
Kavita Dhodapkar, MD – Emory Universityno_symbol.png

3:40 p.m.

Preventing Relapse After CAR T cell Immunotherapy for B cell Malignanices
Terry J. Fry, MD – Children's Hospital of Coloradono_symbol.png

4:00 p.m.

Vaccines Targeting Malignant Brain Tumors
Duane A. Mitchell, MD, PhD – University of Floridano_symbol.png

4:20 p.m. Tumor Microenvironment
Kavita M. Dhodapkar, MD – Emory University
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4:40 p.m.

Characterization of Anti-Tumor Immune Responses and Effects on Survival of Neoadjuvant Oncolytic Virotherapy in Spontaneous Osteosarcoma
Kelly Makielski, DVM, MS – University of Minnesota

4:55 p.m. Closing

Crystal Mackall, MD – Stanford University

5 p.m.

Break

Concurrent Session 214: Basic Biology of Tregs

Co-Chairs:

Sergio A. Quezada, PhD – University College London
Dario A.A. Vignali, PhD – University of Pittsburgh

5:10 p.m.

Targeting Regulatory T Cells for Therapeutic Gain: Means and Mechanisms
Sergio A. Quezada, PhD – University College London

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5:31 p.m.

The TNFR2 Treg Receptor and Oncogene: Dominant Antagonistic Antibody Targeting for Cancer
Denise L. Faustman, MD, PhD – Harvard Medical School


5:51 p.m.

Lactic acid metabolically supports the high suppressive function of tumor infiltrating regulatory T cells
McLane Watson, BS – University of Pittsburghno_symbol.png

6:01 p.m.

Anti-CTLA4 activation of intratumoral NK cells may contribute to intratumoral Treg depletion
Erica Stone, PhD – Wistar Instituteno_symbol.png

6:11 p.m.

Neuropilin-1 Stabilizes Human Tregs in Cancer Patients Leading to More Potent Suppressive Function
Christopher A. Chuckran, BS – University of Pittsburgh School of Medicineno_symbol.png

6:21 p.m.

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Concurrent Session 215: Myeloid Derived Suppressive Populations

Co-Chairs:

Dmitry I. Gabrilovich, MD, PhD – The Wistar Institute
Sourav Ghosh, PhD – Yale School of Medicine

5:10 p.m.

Innate Immune Checkpoints and Cancer Immunotherapy
Sourav Ghosh, PhD – Yale School of Medicineno_symbol.png

5:35 p.m.

Regulation of Myeloid-Derived Suppressor Cells in Cancer
Dmitry I. Gabrilovich, MD, PhD – The Wistar Institute

6:00 p.m.

Reprogramming suppressive myeloid cells in tumor microenvironment with pepinemab, first-in-class Semaphorin 4D Mab, enhances combination immunotherapy
Greg Lesinski, PhD, MPH – Winship Cancer Institute of Emory University

6:15 p.m.

Using artificial intelligence to distinguish subjects with prostate cancer (PCa) from benign prostate hyperplasia (BPH) through immunophenotyping of MDSCs and lymphocyte cell populations
George A. Dominguez, PhD – Anixa Biosciences

Concurrent Session 216: Role of B cells in Immunotherapy & Toxicity

Co-Chairs:

Tullia C. Bruno, PhD – University of Pittsburgh
Madhav Dhodapkar, MD – Emory University

5:10 p.m.

Introduction
Madhav Dhodapkar, MD – Emory Universityno_symbol.png

5:15 p.m.

Role of B cells in Tumors
Tullia C. Bruno, PhD – University of Pittsburghno_symbol.png

5:35 p.m.

Role of B cells in Autoimmunity
Kavita M. Dhodapkar, MD – Emory Universityno_symbol.png

5:55 p.m.

B-cells and tertiary lymphoid structures (TLS) predict response to immune checkpoint blockade (ICB)
Sangeetha Reddy, MD, MSci – MD Anderson Cancer Centerno_symbol.png

6:10 p.m.

Anti-Tumor Immune Responses in Metastatic Breast Cancer Exceptional Responder Patients
William H. Robinson, MD, PhD – Stanford University School of Medicineno_symbol.png

6:25 p.m.

Closing
Tullia C. Bruno, PhD – University of Pittsburgh no_symbol.png

Award Ceremony

6:35 p.m.

Award Ceremony

Poster Reception

7 p.m.

Poster Reception

Sunday, Nov. 11

Annual Meeting

7:30 a.m.

Annual Meeting Organizer Welcome
Dario A.A. Vignali, PhD – University of Pittsburghno_symbol.png

7:35 a.m.

Cancer Immunotherapy Trials Network Update 

Martin A. Cheever, MD – Fred Hutchinson Cancer Research Centerno_symbol.png

Concurrent Session 301: Next Generation Bispecifics and Antibody-Like Molecules

Co-Chairs:

Ignacio Melero, MD, PhD – FIMA - University of Navarra
Farhad Ravandi, MD – University of Texas MD Anderson Cancer Center

8:05 a.m.

Introduction
Ignacio Melero, MD, PhD – FIMA-University of Navarrano_symbol.png

8:10 a.m.

Next Generation T Cell Bispecific Antibodies and Fusion Proteins for Cancer Immunotherapy
Pablo Umaña, PhD – Roche Glycart AGno_symbol.png

8:35 a.m.

Blinatumomab: Can We Improve Efficacy Using Checkpoint Inhibitors
Dirk Nagorsen, MD, PhD – Amgen Inc.no_symbol.png

9 a.m.

Chimeric Antibodies in AML: Hope or Reality?
Farhad Ravandi, MD – University of Texas MD Anderson Cancer Center

9:25 a.m.

A new immunomodulatory strategy of inhibiting the glyco-immune checkpoint axis with EAGLE technology to treat cancer
Li Peng, PhD – Palleon Pharmaceuticals

9:40 a.m.

FS120 mAb2, a dual agonist bispecific antibody targeting OX40 and CD137, activates T cells in vitro and induces potent, FcγR-independent anti-tumour activity
Miguel Gaspar, PhD – F-star Biotechnology ltdno_symbol.png

9:55 a.m.

Immuno-oncology tHERApy with HERA-GITRL: the novel hexavalent human GITR agonist activates T cells and promotes anti-tumor efficacy independent of Fc-functionality
David M. Richards – Apogenix AGno_symbol.png

10:10 a.m.

Closing
Farhad Ravandi, MD – University of Texas MD Anderson Cancer Center

Concurrent Session 302: Clinical Trials Session

Co-Chairs:
Michael Atkins, MD – Georgetown-Lombardi Comprehensive Cancer Center
Mario Sznol, MD – Yale Cancer Center

8:10 a.m. Safety and efficacy of cryopreserved autologous tumor infiltrating lymphocyte therapy (LN-144, lifileucel) in advanced metastatic melanoma patients following progression on checkpoint inhibitors
Amod Sarnaik, MD – H. Lee Moffitt Cancer Center & Researchno_symbol.png
8:25 a.m.

Infusion of TGFβ-resistant EBV-specific T-cells post cytoreductive chemotherapy is safe and associated with clinical benefit in patients with recurrent/metastatic NPC
Christopher DeRenzo, MD – St. Jude Children’s Research Hospital

8:40 a.m. Expert Discussant

Cara Haymaker, PhD – University of Texas MD Anderson Cancer Center


8:50 a.m. Using high dimensional mass cytometry (CyTOF) and machine assisted analysis to detect biomarkers in the immunotherapy of cancer
Carsten Krieg, PhD – Medical University of South Carolinano_symbol.png
9:05 a.m. Monalizumab in combination with cetuximab in recurrent or metastatic squamous cell carcinoma of the head and neck (R/M SCCHN): clinical and translational biomarker results
Roger Cohen – University of Pennsylvania

9:20 a.m. Combination of subcutaneous selicrelumab (CD40 agonist) and vanucizumab (anti-Ang2/VEGF) in patients with solid tumors demonstrates early clinical activity and a favorable safety profile
Emiliano Calvo, MD, PhD – START Madrid

9:35 a.m. A phase 1, open-label, dose-escalation study of enoblituzumab in combination with pembrolizumab in patients with select solid tumors
Charu Aggarwal, MD, MPH – University of Pennsylvaniano_symbol.png
9:50 a.m. Phase 2 trial of mocetinostat in combination with durvalumab in NSCLC patients with progression on prior checkpoint inhibitor therapy
Manish Patel, DO – University of Minnesota Medical Center

10:05 a.m. Expert Discussant
Elad Sharon, MD, MPH – National Institutes of Healthno_symbol.png

10:15 a.m.

Break

Concurrent Session 303: Immunoscore Update Session

10:30 a.m.

Immunoscore Update 
Jerome Galon, PhD – Universite Pierre Et Marie Curie, Sorbonne Universitesno_symbol.png

Concurrent Session 304: Hot Topic Symposium: Lessons from Recent Immuno-Oncology Trials When Active

10:45 a.m.

Introduction
Marc Theoret, MD – U.S. Food & Drug Administration
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10:50 a.m.

Strength of Rationale, Potential Pharmacodynamic/Pharmacokinetic Considerations
Jason J. Luke, MD, FACP – University of Chicago

11:20 a.m.

Dosing and Dosage Regimen
Renzo Canetta, MD

11:35 a.m.

Biomarker Selection Considerations
Roy S. Herbst, MD, PhD – Yale Cancer Center
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11:05 a.m.

Clinical Development Strategy/Trial Design
Mario Sznol, MD – Yale Cancer Center
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11:50 a.m.

Panel Discussion
Moderators: 
Marc Theoret, MD – U.S. Food & Drug Administration
Helen Chen, MD – National Cancer Institute
Panelists:
Renzo Canetta, MD
Roy S. Herbst, MD, PhD – Yale Cancer Center
Jason J. Luke, MD, FACP – University of Chicago
Rajeshwari Sridhara, PhD – U.S. Food & Drug Administration
Mario Sznol, MD – Yale Cancer Centerno_symbol.png

Adjourn

12:15 p.m.

Thank you for attending SITC 2018!

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