SITC Archive Library

Back to Library

SITC 2018 Pre-Conference Program: Immune Escape: Current Understanding of Mechanisms and Advances in Therapeutic Approaches 

11-29-2018 15:24

The Society for Immunotherapy of Cancer (SITC) hosted the "Pre-Conference Program: Immune Escape - Current Understanding of Mechanisms and Advances in Therapeutic Approaches" during the SITC 2018 Annual Meeting on November 7, 2018. Available here are the presentation slides and video from the session.

Program Organizers

  • Adrian Bot, MD, PhD – Kite, a Gilead Company
  • Alessandra Cesano, MD, PhD – Nanostring, Inc.
  • Daniel S. Chen, MD, PhD – IGM Biosciences, Inc.
  • Howard Kaufman, MD, FACS – Replimune Group Inc.
  • Salil Patel, PhD – Bristol-Myers Squibb
  • Eric Rubin, MD – Merck & Co., Inc.

Program Summary

As the categories and number of immunotherapies in clinical practice diversified, it became evident that renewed efforts to characterize and address mechanisms of primary immune resistance and secondary treatment failures are needed. This forum covered current mechanistic understanding of pre-existing and acquired mechanisms of immune resistance to interventions such as immune checkpoint blockade and CAR T cell therapy, with a focus on tumor microenvironment. This was complemented by the newest information pointing to biomarkers that could be useful to identify appropriate immune interventions or combination therapies to overcome such immune resistance. Finally, a series of panel discussions addressed how specific categories of immune therapies such as immune checkpoint blockade, oncolytic viruses and T cell therapies could be utilized most judiciously to maximize the likelihood of clinical success of immunotherapy in face of the diversity of resistance mechanisms.

Disclaimer: Due to the rapidly-evolving field of cancer immunotherapy, some of the content on this page may be out of date. For current information from SITC on cancer immunotherapy, scroll down to view Related Entries and Links.

#ImmuneResponsiveness#BladderCancer#BreastCancers#GastrointestinalCancers
#HeadandNeckCancers#NonSmallCellLungCancer#Lymphoma#PresentationSlides
#Video#AnnualMeeting#SITC#AdverseEvents#AdoptiveCellTherapy#Atezolizumab
#ImmuneCheckpointInhibitors#Pembrolizumab#Vaccines#Clinician#RegisteredNurse
#Oncologist#Pharmacist#Researcher#2018

Statistics
2 Favorited
477 Views
4 Files
0 Shares
624 Downloads

​
Attachment(s)
Download All
pdf file
"Primary and Secondary Mechanisms of Resistance to Autolo...   1.13 MB   1 version
Uploaded - 11-29-2018
Meeting: SITC 33 Annual Meeting: Session: Immune Escape: Understanding of Mechanisms and Advances in Therapeutic Approaches; Session I: Therapeutic Strategies to Overcome Immune Resistance; Presenter: John Rossi, MD – Kite Pharma; Date: November 7, 2018
 
Download
mp4 file
"Primary and Secondary Mechanisms of Resistance to Autolo...   188.24 MB   1 version
Uploaded - 12-03-2018
Meeting: SITC 33 Annual Meeting: Session: Immune Escape: Understanding of Mechanisms and Advances in Therapeutic Approaches; Session I: Therapeutic Strategies to Overcome Immune Resistance; Presenter: John Rossi, MD – Kite Pharma; Date: November 7, 2018
 
Download
pdf file
A Novel Temporospatial Orchestration of the Innate (NK) ...   3.89 MB   1 version
Uploaded - 11-29-2018
Meeting: SITC 33 Annual Meeting: Session: Immune Escape: Understanding of Mechanisms and Advances in Therapeutic Approaches; Session II: Underlying Mechanisms of Immune Escape; Presenter: Patrick Soon-Shiong – NANT Cancer Immunotherapy, Inc.; Date: November 7, 2018
 
Download
mp4 file
A Novel Temporospatial Orchestration of the Innate (NK) ...   255.94 MB   1 version
Uploaded - 12-03-2018
Meeting: SITC 33 Annual Meeting: Session: Immune Escape: Understanding of Mechanisms and Advances in Therapeutic Approaches; Session II: Underlying Mechanisms of Immune Escape; Presenter: Patrick Soon-Shiong – NANT Cancer Immunotherapy, Inc.; Date: November 7, 2018
 
Download

Comments

Anil Shanker
12-24-2018 22:20

Thank you, Dr. Soon-Shiong for presenting your work from the chemo-free NANT immunotherapy trials! Exciting!! This proves our studies that we published in JI, 2007 and Immunology, 2010. - Anil Shanker