SITC Archive Library

The Society for Immunotherapy of Cancer (SITC) hosted the "Pre-Conference Program: Workshop on Nutrition, Metabolism and the Microbiome in Cancer Therapy" during the SITC 2018 Annual Meeting on November 8, 2018. Available here are the presentation slides and video from the program.

Program Organizers

• Jennifer A. Wargo, MD, MMSC – University of Texas MD Anderson Cancer Center 
• Laurence Zitvogel, MD, PhD – Institute Gustave Roussy

Program Summary

Recently, the concept that the intestinal microbiota determines the efficacy of anticancer immunotherapies has been proven by epidemiological associations in clinical studies, as well as by experiments in mouse models. The microbiota offers new prognostic biomarkers as it promises to become the target for future antineoplastic treatments. Over the past few years, a multidimensional network of functional connections between the gut microbiome, intestinal physiology, whole-body metabolism, the immune system and neoplastic disease has emerged. An initial exploration of this new research space has become possible due to rampant technological progress, including, but not limited to improved high-throughput microbiome sequencing technologies aided by refined databases; culturomics to render an ever-growing portion of the microbiota cultivatable and hence investigable; mass spectrometry and single-cell transcriptomics for an in-depth characterization of individual enteric, immune or neoplastic cells; high-throughput metabolomics applicable to distinct organs; and, last but not least, sophisticated bioinformatics tools for data deconvolution and integration. Thus, recent progress has been marked by methodological advances that allowed description of the impact of individual bacterial species on the intestinal barrier and organism-wide immune responses. SITC presented major advances reported in 2016-2017 and future prospects of the microbiome space in cancer therapy.

Disclaimer: Due to the rapidly-evolving field of cancer immunotherapy, some of the content on this page may be out of date. For current information from SITC on cancer immunotherapy, scroll down to view Related Entries and Links.

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