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CAR-T cell therapy: a potential new strategy against prostate cancer

Prostate cancer (PCa) is one of the main causes of cancer-related death in men. In the present immunotherapy era , several immunotherapeutic agents have been evaluated in PCa with poor results, possibly due to its low mutational burden. The recent development of chimeric antigen receptor (CAR...

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Combination immunotherapy and radiotherapy causes an abscopal treatment response in a mouse model of castration resistant prostate cancer

Prostate cancer is poorly responsive to immune checkpoint inhibition, yet a combination with radiotherapy may enhance the immune response. In this study, the authors combined radiotherapy with immune checkpoint inhibition (iRT) in a castration-resistant prostate cancer (CRPC) preclinical model....

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Targeting Interleukin(IL)-30/IL-27p28 signaling in cancer stem-like cells and host environment synergistically inhibits prostate cancer growth and improves survival

Interleukin(IL)-30/IL-27p28 production by Prostate Cancer (PC) Stem-Like Cells (SLCs) has proven, in murine models, to be critical to tumor onset and progression. In PC patients, IL-30 expression by leukocytes infiltrating PC and draining lymph nodes correlates with advanced disease grade and...

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Perception of cure among patients with metastatic genitourinary cancer initiating immunotherapy

Despite the advent of checkpoint inhibitors (CPIs) for advanced genitourinary (GU) cancers, existing studies suggest that durable complete responses are observed in fewer than 10% of patients. This study sought to evaluate the association between expectations of cure reported by patients with...

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Clinical Track - 2019 SITC Cancer Immunotherapy Winter School

The Society for Immunotherapy of Cancer (SITC) hosted the 2019 SITC Cancer Immunotherapy Winter School, a comprehensive cancer immunotherapy education program on F ebruary 18-22, 2019. Available here are the presentation slides and video from the Clinical Track program. (Information regarding...

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