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Antibiotic therapy and outcome from immune-checkpoint inhibitors

Sensitivity to immune checkpoint inhibitor (ICPI) therapy is governed by a complex interplay of tumor and host-related determinants. Epidemiological studies have highlighted that exposure to antibiotic therapy influences the probability of response to ICPI and predict for shorter patient...


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Adoptive Cellular Therapies Workshop - Friday Presentations

Available here are the presentation slides and video recordings from the Friday, September 6, 2019 Adoptive Cellular Therapies Workshop. In the wake of the 2017 U.S. Food and Drug Administration approvals for Chimeric Antigen Receptor (CAR) T cell therapies for the treatment of patients with...

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Adoptive Cellular Therapies Workshop - Thursday Presentations

Available here are the presentation slides and video recordings from the Thursday, September 5, 2019 Adoptive Cellular Therapies Workshop. In the wake of the 2017 U.S. Food and Drug Administration approvals for Chimeric Antigen Receptor (CAR) T cell therapies for the treatment of patients with...

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Cancer Immune Responsiveness Workshop - Thursday Presentations

Available here are the presentation slides and video recordings from the Thursday, September 5, 2019 Cancer Immune Responsiveness Workshop. Building upon the success of 2018's Interim Workshop on Cancer Immune Responsiveness (CIR), the goal of this year's CIR workshop was the continued...

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Cancer Immune Responsiveness Workshop - Wednesday Presentations

Available here are the presentation slides and video recordings from the Wednesday, September 4, 2019 Cancer Immune Responsiveness Workshop. Building upon the success of 2018's Interim Workshop on Cancer Immune Responsiveness (CIR), the goal of this year's CIR workshop was the continued...

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Gut microbiome affects the response to anti-PD-1 immunotherapy in patients with hepatocellular carcinoma

Checkpoint blockade immunotherapy targeting programmed cell death protein 1 (PD-1) has recently shown promising efficacy in hepatocellular carcinoma (HCC). However, the factors affecting and predicting the response to anti-PD-1 immunotherapy in HCC are still unclear. The authors report the...


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Role of antibiotic use, plasma citrulline and blood microbiome in advanced non-small cell lung cancer patients treated with nivolumab

Recent data suggested a role of gut microbiota and antibiotic use on immune checkpoint inhibitors efficacy. The authors aimed to evaluate the impact of early use of antibiotic (EUA), blood microbiome and plasmatic citrulline (marker of the intestinal barrier) on nivolumab efficacy in non-small...




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Exploring the emerging role of the microbiome in cancer immunotherapy

In this review the authors summarize 1) basic methodologies and considerations for studies of host-microbiota interactions; 2) experimental evidence towards a causal link between gut microbiota composition and immunotherapeutic efficacy; 3) possible mechanisms governing the microbiota-mediated...