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Late-differentiated effector neoantigen-specific CD8+ T cells are enriched in peripheral blood of non-small cell lung carcinoma patients responding to atezolizumab treatment

There is strong evidence that immunotherapy-mediated tumor rejection can be driven by tumor-specific CD8+ T cells reinvigorated to recognize neoantigens derived from tumor somatic mutations. Thus, the frequencies or characteristics of tumor-reactive, mutation-specific CD8+ T cells could be used...


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Niclosamide, an antihelmintic drug, enhances efficacy of PD-1/PD-L1 immune checkpoint blockade in non-small cell lung cancer

PD-1/PD-L1 blockade has received approval for clinical application due to its encouraging benefit with improving prognosis in selected populations. Unfortunately, the response to immunotherapy for many patients remains unsatisfactory. It remains a great challenge to generate potential...





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Immunotherapy for the Treatment of Lung Cancer

Published in partnership with the Society for Immunotherapy of Cancer (SITC), this Patient Resource Guide provides current, medically accurate information intended specifically for patients with Lung cancers and their caregivers. Immunotherapy for the Treatment of Lung cancer outlines...

2019 Immunotherapy Lung.pdf


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Immunotherapy in small-cell lung cancer: from molecular promises to clinical challenges

While immune checkpoint inhibitors (ICIs) have had a major impact on the clinical outcome of several solid tumors, including non-small cell lung cancer, the potential role of ICIs is currently under investigation in SCLC and some promising data are available. The authors summarize the current...



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Perilesional edema in brain metastases: potential causes and implications for treatment with immune therapy

Little is known about tumor-associated vasogenic edema in brain metastasis, yet it causes significant morbidity and mortality. The authors' purpose was to characterize edema in patients treated with anti-PD-1 and to study potential causes of vessel leakage in humans and in pre-clinical models....


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Epigenetic alterations are associated with tumor mutation burden in non-small cell lung cancer

The authors profiled genomic and epigenomic data from a naïve Chinese non-small cell lung cancer (NSCLC) cohort and investigated the association between tumor mutation burden (TMB) and DNA methylation (DNAm) to explore potential alternative/complimentary biomarkers for NSCLC immunotherapies. The...