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Targeting interferon signaling and CTLA-4 enhance the therapeutic efficacy of anti-PD-1 immunotherapy in preclinical model of HPV+ oral cancer

The US is experiencing an epidemic of HPV + oropharyngeal cancers (OPC), the rates and burden of which now exceed that for cervical cancer. Immunotherapy targeting programmed death 1 (PD-1) on tumor-infiltrating lymphocytes and/or its ligand PD-L1 on tumor cells, which was effective in...

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Isolation of T cell receptor specifically reactive with autologous tumour cells from tumour-infiltrating lymphocytes and construction of T cell receptor engineered T cells for esophageal squamouscell

T cell receptor-engineered T cells (TCR-Ts) therapy is a promising cancer treatment strategy. Nowadays, most studies focused on identification of high-avidity T cell receptors (TCRs) directed against neoantigens derived from somatic mutations. However, few neoantigens per patient are able to...

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Paired whole exome and transcriptome analyses for the Immunogenomic changes during concurrent chemoradiotherapy in esophageal squamous cell carcinoma

The immunogenomic changes triggered by concurrent chemoradiation therapy (CCRT), a standard neoadjuvant treatment for locally advanced esophageal squamous cell carcinoma (ESCC), are unknown. The authors aimed to analyze the early immunogenomic changes in ESCC induced by CCRT and to correlate...

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Advances in Cancer Immunotherapy™ Webinar Series: Updates from the Field: Clinical Updates from SITC 2018 - Recorded Webinar and Presentation Slides

With cutting-edge data regularly emerging from conferences and new FDA approvals, keeping updated with the latest cancer immunotherapy research is an arduous task for a practicing clinician. To complement and expand upon the live Advances in Cancer Immunotherapy™ (ACI) programs, SITC is proud to...

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SITC Cancer Immunotherapy Guidelines – Squamous Cell Carcinoma of the Head and Neck (HNSCC) Webinar

On July 24, 2019, leading experts in cancer immunotherapy presented an overview of the recently published SITC Cancer Immunotherapy Guidelines – Squamous Cell Carcinoma of the Head and Neck (HNSCC) at a live webinar. This FREE CME-, CNE-, CPE-certified webinar provided a chance for...

 07-24-2019 | 15:00 - 16:00 ET