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High numbers of activated helper T cells are associated with better clinical outcome in early stage vulvar cancer, irrespective of HPV or p53 status

Vulvar squamous cell carcinoma (VSCC) has been suggested to consist of three subtypes; HPV-positive, HPV-negative mutated TP53 or HPV-negative TP53 wildtype, with different clinical courses. To analyze the immune infiltrate in these molecular subtypes and its impact on clinical outcome,...


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A phase I study of the PD-L1 inhibitor, durvalumab, in combination with a PARP inhibitor, olaparib, and a VEGFR1–3 inhibitor, cediranib, in recurrent women’s cancers with biomarker analyses

Strategies to improve activity of immune checkpoint inhibitors are needed. The authors hypothesized enhanced DNA damage by olaparib, a PARP inhibitor, and reduced VEGF signaling by cediranib, a VEGFR1–3 inhibitor, would complement anti-tumor activity of durvalumab, a PD-L1 inhibitor, and the 3...



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Carboplatin/paclitaxel, E7-vaccination and intravaginal CpG as tri-therapy towards efficient regression of genital HPV16 tumors

High-risk human papillomavirus (HPV) are responsible for genital and oral cancers associated with the expression of the E6/E7 HPV oncogenes. Therapeutic vaccines targeting those oncogenes can only partially control tumor progression, highlighting the necessity to investigate different treatment...






Event
11th Breast-Gynecological & Immuno-Oncology International Cancer Conference (BGIICC)

The 11th Breast, Gynecological and Immuno-oncology International Cancer Conference (BGIICC) is the only conference specialized in breast gynecological cancers in Africa and the Middle-East. The 2019 Scientific Program is designed to give a good platform for the exchange of experience on cancers...

 01-17-2019 00:00 - 01-18-2019 23:55 EET
 Cairo Governorate


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Session Descriptions

Advances in Immunotherapy of Breast and Gynecologic Cancers The fields of cancer immunology and immunotherapy are making great advances in developing a comprehensive understanding of the mechanisms underlying tumor immune system interactions and the application of this knowledge to the...