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Immune checkpoint inhibitor related myasthenia gravis: single center experience and systematic review of the literature

Myasthenia gravis (MG) is a rare but life-threatening adverse event of immune checkpoint inhibitors (ICI). Given the limited evidence, data from a large cohort of patients is needed to aid in recognition and management of this fatal complication. The authors reviewed their institutional...


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Dual checkpoint inhibitor-associated eosinophilic enteritis

Eosinophilia has been reported as a rare, new biological effect of immune checkpoint inhibition that may be associated with improved treatment response and the development of immune-related adverse events. The authors report a case of dual checkpoint inhibitor-associated hypereosinophilia and...


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Pericardial effusion under nivolumab: case-reports and review of the literature

Nivolumab, a programmed death-1 (PD-1) inhibitor, is an immune checkpoint inhibitor particularly used in the treatment of malignant melanoma, non-small cell lung cancer and renal cell carcinoma. Immune-related adverse events are frequent under immunotherapies. Cardiotoxic side effects, initially...


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Seronegative autoimmune autonomic ganglionopathy from dual immune checkpoint inhibition in a patient with metastatic melanoma

Immune checkpoint inhibitors have improved clinical outcomes including survival in several malignancies but have also been associated with a range of immune-related adverse events (irAEs). Neurological irAEs are rare compared to the more typical skin, gastrointestinal, and endocrine toxicities,...


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Unchecked immunity: a unique case of sequential immune-related adverse events with Pembrolizumab

The authors present a case of sequential immune-related adverse events (irAEs) in a patient with metastatic melanoma treated with single-agent anti-programmed cell death-1 (PD-1) therapy, pembrolizumab. Although numerous cases of irAEs have been reported, sequential multi-organ involvement,...


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SITC Webinar: I-O Highlights from ASCO 2019 - Recorded Webinar and Presentation Slides

On August 28, 2019, leading experts presented the latest advances in cancer immunotherapy emerging from the 2019 American Society of Clinical Oncology (ASCO) Annual Meeting. The webinar summarized key studies on the following topics: Biomarkers and checkpoint inhibitors Cellular therapies ...

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A case of checkpoint inhibitor-induced celiac disease

Immune checkpoint inhibitors (ICIs) have now become standard of care treatment for many malignancies. ICIs are associated with unique immune mediated adverse events (irAEs) due to dysregulation of immune activation. As treatment with ICIs is becoming more common, rare irAEs are also being...


Event
SITC Webinar: I-O Highlights from ASCO 2019

On Aug. 28, 2019, at Noon EDT, leading experts presented the latest advances in cancer immunotherapy emerging from the 2019 American Society of Clinical Oncology (ASCO) Annual Meeting. The webinar summarized key studies on the following topics: Biomarkers and checkpoint inhibitors Cellular...

 08-28-2019 | 12:00 - 13:00 ET