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Collagen density regulates the activity of tumor-infiltrating T cells

Published in the Journal for ImmunoTherapy of Cancer (JITC), is a research article investigating if a high-density tumor-specific ECM could influence the ability of T cells to kill cancer cells, by studying how T cells respond to 3D culture in different collagen densities. Authors: Dorota E....


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The immune suppressive microenvironment of human gliomas depends on the accumulation of bone marrow-derived macrophages in the center of the lesion

Published in the Journal for ImmunoTherapy of Cancer (JITC), is a research article in which Myeloid and lymphoid infiltrate were characterized in grade II, III and IV gliomas by multicolor flow cytometry, along with the composition of the cell subsets of circulating myeloid cells. Macrophages...


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Suppression of Myeloid Cell Arginase Activity leads to Therapeutic Response in a NSCLC Mouse Model by Activating Anti-Tumor Immunity

Published in the Journal for ImmunoTherapy of Cancer (JITC), is a research article showing that arginase expression is elevated in mouse and patient lung tumors. In a KRAS G12D GEMM arginase inhibition diminished growth of established tumors. the data suggests arginase as an immunomodulatory...


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Immunotherapy of triple-negative breast cancer with cathepsin D-targeting antibodies

Published in the Journal for ImmunoTherapy of Cancer (JITC), is a research article describing how Cath-D is a tumor-specific extracellular target in TNBC suitable for antibody-based therapy. Immunomodulatory antibody-based strategy against cath-D is a promising immunotherapy to treat patients...


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Tumor microenvironment modulation enhances immunologic benefit of chemoradiotherapy

Published in the Journal for ImmunoTherapy of Cancer (JITC), is a research article in which data shows that modulation of the tumor immune microenvironment with CTX/L-NIL enhances susceptibility of treatment-refractory tumors to CRT. Authors: Aurelie Hanoteau, Jared M. Newton , Rosemarie...



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Purinergic targeting enhances immunotherapy of CD73+ solid tumors with piggyBac-engineered chimeric antigen receptor natural killer cells

Published in the Journal for ImmunoTherapy of Cancer (JITC), is a research article which reports pre-clinical data showing that combination immunotherapy with CD73 blockade and CAR-NK-92 cells shows improved anti-cancer effects against CD73 + solid tumor targets both in vitro and in vivo. ...


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Dose escalation results from a first-in-human, phase 1 study of glucocorticoid-induced TNF receptor–related protein agonist AMG 228 in patients with advanced solid tumors

Published in the Journal for ImmunoTherapy of Cancer (JITC), is a research article about open-label, first-in-human, phase 1 study evaluated the safety, pharmacokinetics, pharmacodynamics, and maximum tolerated dose (MTD) of AMG 228, an agonistic human IgG1 monoclonal antibody targeting...


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Living with Melanoma Symposium: Complications of Immunotherapy

Presentation given by Ragini Kudchadkar, MD, as part of the AIM at Melanoma’s Living With Melanoma - Symposium on September 23, 2017 at Winship Cancer institute at Emory University. #Melanoma #Video #CollaborativePartner #SideEffects #AdverseEvents #Biomarkers ...


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Understanding Melanoma: Treatment Options - Immunotherapy

From AIM at Melanoma, this article describes the different immunotherapy treatment options approved for the treatment of melanoma. Click here to read "Understanding Melanoma: Treatment Options - Immunotherapy" #Melanoma #WebPage #CollaborativePartner #Immunomodulators ...