Search

1 to 10 of 33
Sort by

Library Entry
Safety and enhanced immunostimulatory activity of the DRD2 antagonist ONC201 in advanced solid tumor patients with weekly oral administration

Published in the Journal for ImmunoTherapy of Cancer (JITC), is a research article reporting the results of a phase I study that evaluated the safety, pharmacokinetics (PK), and pharmacodynamics (PD) of weekly ONC201. Authors: Mark N. Stein , Jyoti Malhotra , Rohinton S. Tarapore , Usha...


Library Entry
Level of neo-epitope predecessor and mutation type determine T cell activation of MHC binding peptides

Published in the Journal for ImmunoTherapy of Cancer (JITC), is a research article which analyzed several experimental datasets from cancer patients to elaborate better predictive algorithms for T-cell reactivity to neo-epitopes. Authors: Hanan Besser , Sharon Yunger , Efrat Merhavi-Shoham ,...


Library Entry
Bispecific NKG2D-CD3 and NKG2D-CD16 fusion proteins for induction of NK and T cell reactivity against acute myeloid leukemia

Published in the Journal for ImmunoTherapy of Cancer (JITC), is a research article introducing novel “antibody-like” BFP that takes advantage of the highly tumor-restricted expression of NKG2DL and potently activates the reactivity of NK cells or T cells for immunotherapy of AML. Authors: ...


Library Entry
Toward a comprehensive view of cancer immune responsiveness: a synopsis from the SITC workshop

Published in the Journal for ImmunoTherapy of Cancer (JITC), is a review article discussing a workshop held in San Francisco on May 14–15, 2018 that convened immunologists, geneticists, cell biologists, molecular biologists, biophysicists, computational analysts and oncologists, and aimed at two...


Library Entry
The promise of Immuno-oncology: implications for defining the value of cancer treatment

Published in the Journal for ImmunoTherapy of Cancer (JITC), is a position article and guidelines. This paper defines ways in which treatment with I-O is different from other therapies. It also proposes key aspects and attributes of I-O therapies that should be considered in any assessment of...



Library Entry
Collagen density regulates the activity of tumor-infiltrating T cells

Published in the Journal for ImmunoTherapy of Cancer (JITC), is a research article investigating if a high-density tumor-specific ECM could influence the ability of T cells to kill cancer cells, by studying how T cells respond to 3D culture in different collagen densities. Authors: Dorota E....


Library Entry
The immune suppressive microenvironment of human gliomas depends on the accumulation of bone marrow-derived macrophages in the center of the lesion

Published in the Journal for ImmunoTherapy of Cancer (JITC), is a research article in which Myeloid and lymphoid infiltrate were characterized in grade II, III and IV gliomas by multicolor flow cytometry, along with the composition of the cell subsets of circulating myeloid cells. Macrophages...


Library Entry
Suppression of Myeloid Cell Arginase Activity leads to Therapeutic Response in a NSCLC Mouse Model by Activating Anti-Tumor Immunity

Published in the Journal for ImmunoTherapy of Cancer (JITC), is a research article showing that arginase expression is elevated in mouse and patient lung tumors. In a KRAS G12D GEMM arginase inhibition diminished growth of established tumors. the data suggests arginase as an immunomodulatory...


Library Entry
Immunotherapy of triple-negative breast cancer with cathepsin D-targeting antibodies

Published in the Journal for ImmunoTherapy of Cancer (JITC), is a research article describing how Cath-D is a tumor-specific extracellular target in TNBC suitable for antibody-based therapy. Immunomodulatory antibody-based strategy against cath-D is a promising immunotherapy to treat patients...