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Interleukin-1 alpha increases anti-tumor efficacy of cetuximab in head and neck squamous cell carcinoma

Published in the Journal for ImmunoTherapy of Cancer (JITC), is a research article suggesting that IL-1α in combination with cetuximab can induce a T cell-dependent anti-tumor immune response and may represent a novel immunotherapeutic strategy for EGFR-positive HNSCCs. Authors: Madelyn...




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Tbet-positive regulatory T cells accumulate in oropharyngeal cancers with ongoing tumor-specific type 1 T cell responses

Published in the Journal for ImmunoTherapy of Cancer (JITC), is a research article showing that high numbers of both conventional and Tbet co-expressing Foxp3 hi Tregs accumulate in human papilloma virus (HPV)-driven oropharyngeal squamous cell carcinoma (OPSCC). The infiltration of Tbet+...


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Tumor microenvironment modulation enhances immunologic benefit of chemoradiotherapy

Published in the Journal for ImmunoTherapy of Cancer (JITC), is a research article in which data shows that modulation of the tumor immune microenvironment with CTX/L-NIL enhances susceptibility of treatment-refractory tumors to CRT. Authors: Aurelie Hanoteau, Jared M. Newton , Rosemarie...


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Advances in Cancer Immunotherapy™ Webinar Series: Updates from the Field - Clinical Updates from SITC 2018

This webinar provided an update on developments in the field relating to content presented at the Advances in Cancer Immunotherapy programs and focused on applicable information for a clinical audience. More specifically, program organizers Christian M. Capitini, MD, and Zachary S. Morris,...


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A severe case of refractory esophageal stenosis induced by nivolumab and responding to tocilizumab therapy

Published in the Journal for ImmunoTherapy of Cancer (JITC), is a case report of a patient with stage IV pulmonary adenocarcinoma treated for 6 months with nivolumab who developed bilateral sterile conjunctivitis followed by oropharyngeal mucositis and esophagitis complicated by a severe...