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Tbet-positive regulatory T cells accumulate in oropharyngeal cancers with ongoing tumor-specific type 1 T cell responses

Published in the Journal for ImmunoTherapy of Cancer (JITC), is a research article showing that high numbers of both conventional and Tbet co-expressing Foxp3 hi Tregs accumulate in human papilloma virus (HPV)-driven oropharyngeal squamous cell carcinoma (OPSCC). The infiltration of Tbet+...

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Tumor microenvironment modulation enhances immunologic benefit of chemoradiotherapy

Published in the Journal for ImmunoTherapy of Cancer (JITC), is a research article in which data shows that modulation of the tumor immune microenvironment with CTX/L-NIL enhances susceptibility of treatment-refractory tumors to CRT. Authors: Aurelie Hanoteau, Jared M. Newton , Rosemarie...


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Advances in Cancer Immunotherapy™ Webinar Series: Updates from the Field - Clinical Updates from SITC 2018

This webinar provided an update on developments in the field relating to content presented at the Advances in Cancer Immunotherapy programs and focused on applicable information for a clinical audience. More specifically, program organizers Christian M. Capitini, MD, and Zachary S. Morris,...


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A severe case of refractory esophageal stenosis induced by nivolumab and responding to tocilizumab therapy

Published in the Journal for ImmunoTherapy of Cancer (JITC), is a case report of a patient with stage IV pulmonary adenocarcinoma treated for 6 months with nivolumab who developed bilateral sterile conjunctivitis followed by oropharyngeal mucositis and esophagitis complicated by a severe...


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High and low mutational burden tumors versus immunologically hot and cold tumors and response to immune checkpoint inhibitors

Published in the Journal for ImmunoTherapy of Cancer (JITC), is a commentary on the evaluation of tumors based on both their immune phenotype and genomic mutation profile to determine which patients have a higher likelihood of responding to treatment with ICIs. Author: Saman Maleki Vareki ...



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A systematic review of the cost and cost-effectiveness studies of immune checkpoint inhibitors

Published in the Journal for ImmunoTherapy of Cancer (JITC), is a systematic assessment of the cost-effectiveness (CE) of ICIs. Authors: Vivek Verma , Tanja Sprave , Waqar Haque , Charles B. Simone II , Joe Y. Chang , James W. Welsh and Charles R. Thomas Jr. JITC(2018) 1:128 ...



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A nomogram-based immunoprofile predicts overall survival for previously untreated patients with esophageal squamous cell carcinoma after esophagectomy

Published in the Journal for ImmunoTherapy of Cancer (JITC), is a research article where researches examined the infiltration of four immune cell types (CD8+ /CD4+/Foxp3+/CD33+ cells), the expression of both inhibitory (PD-1/PD-L1/Tim-3/LAG-3) and stimulatory checkpoints (OX-40/ICOS), and IDO1...


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Serious adverse events and fatal adverse events associated with nivolumab treatment in cancer patients

Published in the Journal for ImmunoTherapy of Cancer (JITC), is a research article that aims to summarize nivolumab-related serious adverse events (SAEs) and fatal adverse events (FAEs) and to estimate the incidence and risk of SAEs/FAEs by conducting a meta-analysis among adult patients with...