Cancer Immune Responsiveness Workshop

Starts:  May 14, 2018 8:00 AM (PT)
Ends:  May 15, 2018 5:00 PM (PT)

Workshop Overview Leadership Hotel and Travel Registration  Program Agenda

REGISTER NOW

Program Purpose
This workshop promises to be a dynamic and lively opportunity to help determine which questions in cancer cell biology must be answered in order to understand patterns of immune interaction between the host and cancers of different ontology. Topics slated for discussion include the role of the host's genetic background and/or environmental modifiers in cancer immune biology, the role of adaptive versus innate immune mechanisms in initiating immune activation, and the development of improved in vivo models for screening therapeutic strategies.

Over the course of the two-day workshop, participants will attend five didactic sessions, each followed by an interactive panel discussion, and later split into working groups tasked with refining and prioritizing key questions identified. By contributing to defining pivotal questions in cancer immune responsiveness/resistance, participants will help deepen understanding of the cancer biology that orchestrates distinct immune landscapes, and help move the field towards improved therapeutic strategies.

Following the workshop, the SITC Cancer Immune Responsiveness Task Force will convene five working groups, incorporating workshop attendees, to address these key questions in the years ahead.

Program Committee

Chair Francesco M. Marincola, MD
Co-Chair Alessandra Cesano, MD, PhD – NanoString Technologies
Paolo A. Ascierto, MD – Istituto Nazionale Tumori-Fondazione 'G. Pascale'
Lisa H. Butterfield, PhD – University of Pittsburgh
Mary L. Disis, MD – University of Washington
Bernard A. Fox, PhD – Earle A. Chiles Research Institute, Robert W. Franz Cancer Center
Teri Foy, PhD – Celgene
Howard L. Kaufman, MD, FACS – Replimune Group Inc.
Magdalena Thurin, PhD – National Institutes of Health

Working Group Chairs

Davide Bedognetti, MD, PhD – Sidra Medical and Research Center
Rongze Lu, PhD – AbbVie 
Josue Samayoa, PhD – AbbVie 
Stefanie Spranger, PhD – Koch Institute for Integrative Cancer Research at MIT
Sarah Warren, PhD – NanoString Technologies

Hotel and Travel

Hotel
999 California Street, San Francisco, California 94108
Contact: 415-392-3434 | Fax: 415-421-3302

SITC has organized a block of rooms at $269 per night at the meeting hotel. Click here to book your hotel room on the InterContinental Mark Hopkins Hotel website. 
Click on the “BOOK NOW” link in the upper right hand corner of the page. Click "More Options" next to the gold Search button and the SITC discount Group Code “SIC” will automatically show and allow for the discounted group rates.   

To make your hotel reservation by phone, please contact the IHG Reservation Department at +1 800-662-4455. Identify yourself as a participant of the SITC Group (Code: SIC) in order to receive the negotiated rates of $269 per night.

Hotel Reservation deadline is Wednesday, May 2, 2018. After that time, reservations are considered based on availability.

Travel

Major Airports

The San Francisco Bay Area has three major airports with airline service.

For travel tips and security updates, please visit tsa.gov.

Shuttles
Intercontinental Mark Hopkins Hotel does not offer shuttle service. The BayPorter Express and SuperShuttle provide shuttle services from both San Francisco International Airport and Oakland International Airport to downtown San Francisco. 
Fares are approximate and subject to change.

Taxi Services
Taxi stands are located at all the major airports as well as most hotels, attractions and shopping centers. From the San Francisco International Airport to the InterContinental Mark Hopkins Hotel fares are approximately $45*. From the Oakland International Airport, the fare is $40* to the hotel. For more information about the taxi fares, please visit www.taxifarefinder.com.
*Fares are approximate and subject to change.

Trains
Trains arrive at the SFO International Terminal every 15 minutes and it's just 30 minutes to downtown San Francisco. A one-way ticket from SFO to downtown is approximately $9.65*. The BART (Bay Area Rapid Transit) station at SFO is located in the International Terminal. The Oakland Airport BART station is located just across from the Terminal 1 baggage claim area and a short walk from Terminal 2. *Fares are approximate and subject to change.

Registration
To register click Cancer Immune Responsiveness Workshop.

Registration rates for members and non-members are listed below:


Member Type


Early Registration Rate


Onsite 
Registration Rate

Industry Member

$880

$930

Industry Non-Member

$1,100

$1,150

Non-Industry Member

$400

$450

Non-Industry Non-Member

$480

$530


Consider also registering for SITC’s Immuno-Oncology Biomarkers: State of the Art workshop, taking place at the same location on May 16 – 17, 2018, and receive a 50 percent discount on that registration fee.

Cancellation Policy

All cancellations must be received in writing. You may fax your cancellation to +1 888-289-9844 or e-mail education@sitcancer.org. Requests must be submitted by April 14, 2018. A $50 processing fee will be charged for all cancellations. All refunds will be processed after the programs; you will receive an e-mail confirmation. No refunds will be granted if cancellation is received after April 14, 2018. Special considerations will be given for health or family emergencies if requested in writing to education@sitcancer.org no later than 15 business days after the last day of the programs.

Program Agenda
(Tentative Schedule as of April 9, 2018)

Monday, May 14 (Times are subject to change)

Registration
Time: 7:00 – 8:00 a.m.
Location: Lobby Terrace

Breakfast
Time: 7:00 – 8:00 a.m.
Location: Lobby Terrace

Opening Remarks
Time: 8:00 – 8:05 a.m.
Location: Peacock Court
Organizer: Francesco M. Marincola, MD

Session I: Germline Genetic Contributions to Immune Landscape
Time: 8:05 – 9:25 a.m.
Location: Peacock Court
Chair: Davide Bedognetti, MD, PhD – Sidra Medical and Research Center 

8:05 a.m. Efficacy Through Diversity: The Role of HLA Polymorphism in Response to Checkpoint Blockade Immunotherapy  
                 Diego Chowell, PhD – Memorial Sloan Kettering Cancer Center

8:25 a.m. Germline Analysis of Tumor Immune Signatures in TCGA   
                 Elad Ziv, MD – University California, San Francisco

8:45 a.m. Germline Genetic Risk of Autoimmunity and Its Effect on Immunotherapy Response and Toxicity    
                 Tomas Kirchhoff, PhD – New York University Medical Center

9:05 a.m. Applying Germ-Line Microrna Mutations to Predict Response and Toxicity to Immune Therapy    
                Joanne B. Weidhaas, MD, PhD, MSM – University of California, Los Angeles

Session II: Somatic Genetics / Epigenetics of Immune Landscape
Time: 9:25 – 10:25 a.m.
Location: Peacock Court
Chair: Josue Samayoa, PhD – AbbVie  

9:25 a.m.Title to be Determined
               
Vésteinn Thorsson, PhD – Institute for Systems Biology 

9:45 a.m. Enhancing Anti-Tumor Immune Response Using Epigenetic Therapy   
                 
Daniel De Carvalho, PhD – University of Toronto

10:05 a.m.Translational Systems Immunology in Therapeutics Development 
                  
Richard Simon, DSc – National Cancer Institute

10:25 a.m.     Break
Location:        Lobby Terrace 

Session III: Transcriptional Patterns of Distinct Immune Landscapes
Time: 10:40 a.m. – 12:30 p.m.
Location: Peacock Court
Chair: Stefani Spranger, PhD – Koch Institute for Integrative Cancer Research at MIT 

10:40 a.m.Tumor-Intrinsic Pathway Activation Associated With the Non-T Cell-Inflamed Tumor Microenvironment 
                  Jason J. Luke, MD, FACP – University of Chicago

11:00 a.m. Preclinical Models to Elucidate Tumor Immune Microenvironment
                  Kwok-Kin Wong, MD, PhD – Dana-Farber Cancer Institute, Harvard Medical School

11:20 a.m. Targeting the Pancreatic Tumor Microenvironment to Improve Responses to Immunotherapy 
                   David G. DeNardo, PhD – Washington University, St. Louis

11:40 a.m. Pattern Recognition Receptor and Interferon Signaling in Cancer Immunotherapy
                  Andy J. Minn, MD, PhD – University of Pennsylvania

12:00 p.m.   Panel Discussion for Sessions I, II and III

Moderators: Davide Bedognetti, MD, PhD – Sidra Medical and Research Center
                    Josue Samayoa, PhD – AbbVie 
                    Stefani Spranger, PhD – Koch Institute for Integrative Cancer Research at MIT
Participants: Diego Chowell, PhD – Memorial Sloan Kettering Cancer Center
                     Elad Ziv, MD – University California, San Francisco
                     Tomas Kirchhoff, PhD – New York University Medical Center
                     Joanne Weidhaas, MD, PhD, MSM – University of California, Los Angeles
                     Daniel De Carvalho, PhD – University of Toronto
                     Richard Simon, DSc – National Cancer Institute
                     Jason J. Luke, MD, FACP – University of Chicago
                     Kwok-Kin Wong, MD, PhD – Dana-Farber Cancer Institute, Harvard Medical School
                     David DeNardo, PhD – Washington University, St. Louis
                     Andy J. Minn, MD, PhD – University of Pennsylvania

12:30 p.m.       Lunch
Location:          Lobby Terrace                 

Session IV: Role of Immunogenic Cell Death
Time: 1:30 – 2:30 p.m.
Location: Peacock Court
Chair: Sarah Warren, PhD – NanoString Technologies, Inc. 

1:30 p.m. Immunogenic Cell Death in Cancer Therapy, From Cells to Patients
                Lorenzo Galluzzi, PhD – Stich Radiation Oncology

1:50 p.m. Boosting Cancer Immunity: How Oncolytic Viruses Kill Tumor Cells 
                 Howard L. Kaufman, MD, FACS – Replimune Group Inc.

2:10 p.m. The DAMP Hypothesis: Unscheduled Cell Death Regulates the Immune Tumor Microenvironment 
                  Michael T. Lotze, MD – University of Pennsylvania

2:30 p.m.        Break
Location:         Lobby Terrace


Session V: Experimental Models of the Immune Landscape
Time: 2:45 – 4:45 p.m.
Location: Peacock Court
Chair: Rongze Lu, PhD – AbbVie  

2:45 p.m. Next Generation Humanized Mice for Cancer Immunotherapy
                 Lenny Shultz, PhD – Jackson Laboratory Cancer Center

3:05 p.m. Leveraging Mouse Models to Study Sensitivity and Resistance to Cancer Therapies
                 Katerina Politi, PhD – Yale University

3:25 p.m. Humanized Mice to Study Cancer-Immune System Interface 
                 A. Karolina Palucka, MD, PhD – The Jackson Laboratory for Genomic Medicine

3:45 p.m. Modulating Immune Response: Lessons Learned from Mouse Models of Human Cancer
                 Lisa Coussens, PhD – Oregon Health & Science University

4:05 p.m. Panel Discussion for Sessions IV and V
                   
Moderators:    Sarah Warren, PhD – NanoString Technologies, Inc.
                       Rongze Lu, PhD – AbbVie 
Participants:   Lorenzo Galluzzi, PhD – Stich Radiation Oncology
                       Howard L. Kaufman, MD, FACS – Replimune Group Inc.
                       Michael T. Lotze, MD – University of Pennsylvania
                       Lenny Schultz, PhD – Jackson Laboratory Cancer Center
                       Katerina Politi, PhD – Yale University
                       A. Karolina Palucka, MD, PhD – The Jackson Laboratory for Genomic
Medicine
                       Lisa M. Coussens, PhD – Oregon Health & Science University

4:35 p.m. Closing Remarks
                 Francesco M. Marincola, MD
 
4:45 p.m. Reception
                 Room of Don's   

Tuesday, May 15

8:00 a.m.        Opening Remarks
                       
Francesco M. Marincola, MD

Working Group Breakouts
8:05 a.m. – 12:00 p.m.

Working Group 1: Germline Genetic Contributions to Immune Landscape 
Location:        Florentine & Garden

Working Group 2: Somatic Genetics / Epigenetics of Immune Landscape 
Location:        Six Continents

Working Group 3: Transcriptional Patterns of Distinct Immune Landscapes
Location:        George D. Smith

Working Group 4: Role of Immunogenic Cell Death
Location:        Willard

Working Group 5: Experimental Models of the Immune Landscape
Location:        Barclay

Working Group Presentations
1:00 p.m.  – 4:00 p.m. 
Location:        Peacock Court    

1:00 p.m. Working Group 1: Germline Genetic Contributions to Immune Landscape 
Location:        Florentine & Garden

1:30 p.m. Working Group 2: Somatic Genetics / Epigenetics of Immune Landscape 
Location:        Six Continents

2:00 p.m. Working Group 3: Transcriptional Patterns of Distinct Immune Landscapes
Location:        George D. Smith

2:30 p.m. Working Group 4: Role of Immunogenic Cell Death
Location:        Willard

3:00 p.m. Working Group 5: Experimental Models of the Immune Landscape
Location:        Barclay

3:30 p.m. Closing Remarks
                 
Francesco M. Marincola, MD

Location

InterContinental Mark Hopkins Hotel
999 California Street
San Francisco, CA 94108

Contact

SITC Education

Education@sitcancer.org