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Session #8: Late Breaking Special Session (ASH-SITC JOINT Session)
John Tisdale, MD - NIH Molecular & Clinical Hematology
Nina Shah, MD - University of California San Diego
The Immune Predictors of Response to CAR T and Bispecific T Cell Therapy
Paola Neri, MD, PhD - University of Calgary
Novel Technologies to Improve and Safely Deliver Gene Therapies
Jennifer E. Adair, PhD - Fred Hutchinson Cancer Center
Dr. Paola Neri will discuss the Immune predictors of response to chimeric antigen receptor (CAR) T and bispecific T cell therapy in multiple myeloma (MM). She will start by describing the mechanisms of tumor escape that allow MM progression and development of immune dysfunction. Next, she will review the T-Cell based strategies developed to overcome immune escape with a focus on CAR-T and bispecific T cell therapy. Lastly, Dr. Neri will discuss the causes of resistance to these therapies and how a comprehensive genomic analysis of the tumor together with the study of the immune cell repertoire can help to identify patients with the highest likelihood of respond to these therapies and lead to the development of prevention strategies.