SITC Resource Library

On October 13, 2021, leading experts from the SITC Immune Effector Cell-related Adverse Events Guideline Expert Panel presented the "SITC Clinical Practice Guideline Webinar – Case Studies in Immune Effector Cell-related Adverse Events." This high-level webinar covered advanced concepts of toxicity management and risk factors drawing from recommendations within the Clinical Practice Guideline (CPG). The recorded webinar and presentation slides are available below.

Webinar Faculty:

• Moderator: Marcela V. Maus, MD, PhD — Massachusetts General Hospital (Expert Panel Chair)
• Shannon L. Maude, MD, PhD — Children’s Hospital of Philadelphia and University of Pennsylvania (Expert Panel Member)
• Michael R. Bishop, MD — The University of Chicago (Expert Panel Member)

The webinar illustrates how the SITC guideline recommendations can be used while managing toxicities related to CAR T therapies, specifically in cases involving:

• Low-grade cytokine release syndrome (CRS) + high-grade neurotoxicity
• Long-term toxicities, including cytopenias
• Severe CRS HLH/MAS

Disclaimer: Due to the rapidly-evolving field of cancer immunotherapy, some of the content on this page may be out of date. For current information from SITC on cancer immunotherapy, please visit connected.sitcancer.org, or check out our free CPG mobile app.

The Practical Management Pearls and Case Studies Webinars are part of the Cancer Immunotherapy Clinical Practice Guidelines Advanced Webinar Series supported, in part, by grants from Amgen and Merck & Co., Inc. (as of 9/15/2021).
The SITC Clinical Practice Guidelines are produced by SITC and have no funding from outside sources.