SITC Resource Library

SITC 2017 Annual Meeting: Workshop on Single Cell Techniques in Immunology and Cancer Immunotherapy - Enduring Materials 

11-17-2017 14:18

The Society for Immunotherapy of Cancer (SITC) hosted the "Workshop on Single Cell Techniques in Immunology and Cancer Immunotherapy" during the SITC 2017 Annual Meeting on November 9, 2017. Available here are the presentation slides and video from the workshop.

Program Organizers

  • Gordon J. Freeman, PhD – Dana-Farber Cancer Institute
  • Nir Hacohen, PhD – Massachusetts General Hospital
  • Nicholas McGranahan, PhD – University College London

Program Summary

Historically, molecular analyses have been performed on heterogeneous populations of cells, where observed patterns represent a combination of the unique characteristics of each individual cell. In the last few years, single cell techniques combined with high-throughput technologies, such as multiplex quantitative PCR, next generation DNA and RNA sequencing, and state-of-the-art flow cytometry by time of flight (CyTOF), have revolutionized the field, allowing for high-dimensional analysis of isolated subpopulations of individual cells.

With these techniques, researchers have the opportunity to address key challenges barring advancements in the field of cancer immunotherapy, including resolving intratumoral heterogeneity, understanding rare tumor and immune cell populations, tracing cellular lineages and mutational rates, and elucidating complex cellular interactions within the tumor microenvironment both before and after treatment. To demonstrate the potential of single cell techniques in cancer immunotherapy research, this day-long workshop will focus on recent technical and analytical advances specific to single cell techniques to help drive the field forward.

Specifically, this program will begin with an overview of tumor heterogeneity and evolution under immune pressure, with a focus on neoantigen presentation, recognition, and evolution. In the second session of this workshop, changes in myeloid cell populations within the tumor microenvironment both prior to and after immunotherapy treatment will be presented. Moreover, predictors of response to therapy as well as the analysis of liquid tumor biopsies will also be discussed. In order to provide attendees guidance on how to apply single cell techniques to their own research, this workshop will conclude with a panel-led discussion with audience participation focused on experimental approaches and computational methods for single cell techniques.

Intended Audience

The intended audience for this annual, one-day program includes basic scientists and clinical investigators from academic institutions, industry and regulatory agencies. Additional audiences benefiting from this program include clinicians, graduate students, and postdoctoral fellows involved in cancer research and its translation into clinical practice.

Disclaimer: Due to the rapidly-evolving field of cancer immunotherapy, some of the content on this page may be out of date. For current information from SITC on cancer immunotherapy, scroll down to view Related Entries and Links.

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#NonSmallCellLungCancer#RenalCellCarcinoma#AdoptiveCellTherapy
#ImmuneCheckpointInhibitors#Biomarkers

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pdf file
"Tumor Neoantigens and Presentation and Recognition" - Pr...   4.57 MB   1 version
Uploaded - 11-17-2017
Meeting: SITC 32 Annual Meeting; Workshop on Single Cell Techniques in Immunology and Cancer Immunotherapy; Session I: Tumor Heterogeneity and Evolution under Immune Pressure and Treatment; Presenter: James R. Heath, PhD – California Institute of Technology; Date: November 9, 2017
mp4 file
"Tumor Neoantigens and Presentation and Recognition" - Video   319.70 MB   1 version
Uploaded - 12-06-2017
Meeting: SITC 32 Annual Meeting; Workshop on Single Cell Techniques in Immunology and Cancer Immunotherapy; Session I: Tumor Heterogeneity and Evolution under Immune Pressure and Treatment; Presenter: James R. Heath, PhD – California Institute of Technology; Date: November 9, 2017
pdf file
"Computational Methods for Analyzing Single Cells in the ...   15.25 MB   1 version
Uploaded - 11-17-2017
Meeting: SITC 32 Annual Meeting; Workshop on Single Cell Techniques in Immunology and Cancer Immunotherapy; Session II: Tumor Immune Microenvironment; Presenter: Dana Pe’er, PhD – Sloan Kettering Cancer Center; Date: November 9, 2017
mp4 file
"Computational Methods for Analyzing Single Cells in the ...   328.43 MB   1 version
Uploaded - 12-06-2017
Meeting: SITC 32 Annual Meeting; Workshop on Single Cell Techniques in Immunology and Cancer Immunotherapy; Session II: Tumor Immune Microenvironment; Presenter: Dana Pe’er, PhD – Sloan Kettering Cancer Center; Date: November 9, 2017
pdf file
"PDL1 Response" - Presentation Slides   5.43 MB   1 version
Uploaded - 11-17-2017
Meeting: SITC 32 Annual Meeting; Workshop on Single Cell Techniques in Immunology and Cancer Immunotherapy; Session III: Predictor Response & Liquid Biopsy; Priti Hegde, PhD – Genentech; Date: November 9, 2017
mp4 file
"PDL1 Response" - Video   354.26 MB   1 version
Uploaded - 12-06-2017
Meeting: SITC 32 Annual Meeting; Workshop on Single Cell Techniques in Immunology and Cancer Immunotherapy; Session III: Predictor Response & Liquid Biopsy; Presenter: Priti Hegde, PhD – Genentech; Date: November 9, 2017
pdf file
"Pre & Post PD1" - Presentation Slides   3.79 MB   1 version
Uploaded - 11-17-2017
Meeting: SITC 32 Annual Meeting; Workshop on Single Cell Techniques in Immunology and Cancer Immunotherapy; Session III: Predictor Response & Liquid Biopsy; Presenter: Sean Mackay – IsoPlexis; Date: November 9, 2017
mp4 file
"Pre & Post PD1" - Video   222.60 MB   1 version
Uploaded - 12-06-2017
Meeting: SITC 32 Annual Meeting; Workshop on Single Cell Techniques in Immunology and Cancer Immunotherapy; Session III: Predictor Response & Liquid Biopsy; Presenter: Sean Mackay – IsoPlexis; Date: November 9, 2017
pdf file
"Influence of Gut Microbiome upon PD1/I-O Responses" - Pr...   4.30 MB   1 version
Uploaded - 11-17-2017
Meeting: SITC 32 Annual Meeting; Workshop on Single Cell Techniques in Immunology and Cancer Immunotherapy; Session III: Predictor Response & Liquid Biopsy; Presenter: Jennifer A. Wargo, MD, MMSc – University of Texas MD Anderson Cancer Center; Date: November 9, 2017
mp4 file
"Influence of Gut Microbiome upon PD1/I-O Responses" - Video   348.57 MB   1 version
Uploaded - 12-06-2017
Meeting: SITC 32 Annual Meeting; Workshop on Single Cell Techniques in Immunology and Cancer Immunotherapy; Session III: Predictor Response & Liquid Biopsy; Presenter: Jennifer A. Wargo, MD, MMSc – University of Texas MD Anderson Cancer Center; Date: November 9, 2017
pdf file
"Discussion on Experimental and Computational Methods" - ...   46.95 MB   1 version
Uploaded - 11-17-2017
Meeting: SITC 32 Annual Meeting; Workshop on Single Cell Techniques in Immunology and Cancer Immunotherapy; Session IV: How to Apply Single Cell to Your Research; Presenter: Alexandra-Chloé Villani, PhD – Broad Institute of Massachusetts Institute of Technology; Date: November 9, 2017
mp4 file
"Discussion on Experimental and Computational Methods" - ...   564.64 MB   1 version
Uploaded - 12-06-2017
Meeting: SITC 32 Annual Meeting; Workshop on Single Cell Techniques in Immunology and Cancer Immunotherapy; Session IV: How to Apply Single Cell to Your Research; Presenter: Alexandra-Chloé Villani, PhD – Broad Institute of Massachusetts Institute of Technology; Date: November 9, 2017