SITC Archive Library

The Society for Immunotherapy of Cancer (SITC) hosted "Concurrent Session I: Metabolic and Age Associated Dysregulation of Anti-Cancer Immunity" during the SITC 31st Annual Meeting & Associated Programs on November 11-13, 2016. Available here is the video from this session.

Co-Chairs:

• Tom Misteli, PhD – National Cancer Institute, National Institutes of Health
• Graham P. Pawelec, PhD – University of Tuebingen
  
  

Program Summary

The inflammatory response is tightly regulated by a complex cascade of metabolic and genomic signals. Aberrations in these signaling pathways due to aging or metabolic alterations can result in compromised immune function and an impaired ability to mount a response against pathogens as well as cancer. Understanding the mechanisms underlying this dysregulation is essential for developing therapeutic strategies to restore immunity in patients with cancer. Therefore, this session will highlight recent advances surrounding the metabolic and age-related factors involved in the dysregulation of the antitumor response. Topics covered will include a discussion of the therapeutic potential of T cells reactive to idoleamine 2, 3 dioxygenase (IDO) or programmed cell death ligand-1 (PD-L1) as well as the role of myeloid-derived suppressors cells (MDSC) in the aging and tumor microenvironments. Organized in collaboration with the American Society for Cell Biology (ASCB)

Intended Audience

The intended audience for this program includes U.S. and international researchers, regulators and healthcare professionals involved in cancer research and clinical care. This included, but was not limited to basic, translational and clinical researchers; postdoctoral fellows; oncologists; registered nurses; nurse practitioners; pharmacists; payers; and other allied health professionals. 

Disclaimer: Due to the rapidly-evolving field of cancer immunotherapy, some of the content on this page may be out of date. For current information from SITC on cancer immunotherapy, scroll down to view Related Entries and Links.

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