The Society for Immunotherapy of Cancer (SITC) developed and published the first evidence-based consensus statement on tumor immunotherapy for the treatment of patients with cutaneous melanoma in Nature Reviews Clinical Oncology in 2013.
On Wednesday, May 30, 2018, SITC published an update in the Journal for ImmunoTherapy of Cancer (JITC), the society's open access, peer-reviewed online journal.
This updated consensus statement provides expert evidence-based recommendations for the use of immunotherapies including checkpoint inhibitor monotherapies and combinations, as well as oncolytic viruses, interferon-α2, and interleukin-2 in various disease stages and settings. This statement also includes recommendations for patient selection, sequencing or combination of therapies, using and screening for predictive biomarkers, managing adverse events, and selecting optimal clinical endpoints.
SITC Cancer Immunotherapy Guidelines (CIGs) are a collection of clinical practice guidelines developed by multi-disciplinary panels of experts who draw from their own practical experience as well as evidence in the published literature and clinical trial data to develop evidence- and consensus-based recommendations. SITC uses as a model the Institute of Medicine's 2011 "Standards for Developing Trustworthy Clinical Practice Guidelines" to ensure the recommendations are unbiased, transparent and balanced and will aid oncologists in effective clinical decision-making concerning patient selection, toxicity management, response evaluation, and the sequencing or combination of therapies, among other topics.