Registration & Breakfast7–8 a.m.
Opening Remarks8–8:10 a.m.
Keynote Address8:10–9:10 a.m.
Targeting The Tissue and Tumor Microenvironment and Microbiome To Promote Health and End CancerJennifer A. Wargo, MD, MMSc – The University of Texas MD Anderson Cancer Center
Session I: Visualizing the TME9:10–10:50 a.m.
Integrating Tumor Heterogeneity for Radiomics Guided Radio-immunotherapy?Eric Deutsch, MD, PhD – Gustave Roussy Cancer Campus
Autofluorescence Imaging of Immune Cell MetabolismMelissa Skala, PhD – Morgridge Institute for Research
Session II: Metabolism: Nutrient Availability and Competition11:05 a.m.–12:35 p.m.
Impact of Extracellular Nutrients on Tumor BiologyMatt Vander Heiden, MD, PhD – Koch Institute at MIT
Metabolic Alterations in the Tumor-Draining Lymph Node-NicheAngela Riedel, PhD – University of Würzburg
Dissecting the Role of Metabolites in the Tumor MicroenvironmentMarcia C. Haigis, PhD – Harvard Medical School
(O5) Lactate uptake through MCT11, a novel monocarboxylate transporter, enforces dysfunction in terminally exhausted T cells Ronal Peralta, BS – University of Pittsburgh
Session III: Pediatric Tumors2:05–3:35 p.m.
OsteosarcomaChristian M. Capitini, MD – University of Wisconsin-Madison
Immune Landscape of Rhabdoid Tumors: Non-Genetic Mechanisms of Tumor ImmunogenicityEliane Piaggio, MD – Institut Curie
TBARosandra (Rosie) Kaplan, MD – National Cancer Institute, NIH
(O2) Spatiotemporal co-dependency between macrophages and exhausted CD8+ T cells in cancer Kelly Kersten, PhD – University of California San Francisco
Session IV: Oncogenomics and Immunology 3:50–5:20 p.m.
Immune and Malignant Cell Phenotypes of Ovarian Cancer are Determined by Distinct Mutational ProcessesSohrab Shah, PhD – Memorial Sloan Kettering Cancer Center
Effects of Germline Genetics on the TMEDavide Bedognetti, MD, PhD – Sidra Medicine
Targeting the Interaction of Oncogenic Signaling with Immunity in Breast CancerSangeetha Reddy, MD, MSci – University of Texas Southwestern
(O1) Characterization of molecular and spatial diversity of macrophages in hepatocellular carcinomaPauline Hamon, PhD – Icahn School of Medicine, Mount Sinai
Poster Session5:20–6:20 p.m.
Session I: Metabolism: Hypoxia and Acidity (Whole Environment)8:10–9:40 a.m.
Stress Induced Re-programming of Metabolic Pathways in the Tumor Microenvironment: A Mechanism of Immunosuppression?Elizabeth A. Repasky, PhD – Roswell Comprehensive Cancer Center
Microenvironmental Metabolites Shaping T Cell Fate and Function in CancerGreg M. Delgoffe, PhD – University of Pittsburgh
(O7) Breast Tumor Cell Heme Metabolism Alters Macrophage Polarization and Function to Support Lung MetastasisMichelle Williams, PhD – University of Colorado Anschutz Medical Campus
Session II: Metastatic TMEs9:40–10:55 a.m.
Metabolic Control of Tumor Immunity and TherapyWeiping Zou, MD, PhD – University of Michigan
The Functional Contribution of Stromal Fibroblasts and ECM in the Pathogenesis and Immunotherapy Response in Pancreatic Cancer
Raghu Kalluri, MD, PhD – The University of Texas MD Anderson Cancer Center
(O3) High-dimensional Image Cytometry Reveals Spatially Organized Tumor-immune Microenvironment in Hepatocellular Carcinoma Haoyang Mi, MS – Johns Hopkins University School of Medicine
Normalizing the Tumor Microenvironment to Improve Immunotherapy: Bench to BedsideRakesh Jain, PhD – Massachusetts General Hospital and Harvard Medical School
(O6) Sox2 expression in NSCLC impairs tumor T cell infiltration and promotes resistance to checkpoint blockade therapy Elen Torres-Mejia, PhD – Koch Institute at MIT
Session IV: Methods for Manipulating and Studying the TME2:25–3:55 p.m.
Intratumoral Cytokine Therapy - Principles and PracticeNoor Momin, PhD – Massachusetts Institute of Technology
Scgb1a1+ Club Cells Increase the Efficacy of Immune Checkpoint Blockade in Lung CancerVivek Mittal, PhD – Weill Cornell Medicine
Immunological Mechanisms of Resistance to CDK4/6 Inhibitors in Breast CancerLorenzo Galluzzi, PhD – Weill Cornell Medicine
(O4) Microbiota-specific T follicular helper cells support tertiary lymphoid structure formation and anti-tumor immunity in colorectal cancerAbigail Overacre-Delgoffe, PhD – University of Pittsburgh
Closing Remarks3:55–4 p.m.
If you have questions about this program, please contact the SITC Education team
TME WORKSHOP HOMEPAGE
Tel: +1 414 271 2456 | Fax: +1 414 276 3349 | Email: firstname.lastname@example.org