COVID-19 Considerations for Basic and Translational Research

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Histamine as a therapeutic target to dampen immune response in COVID-19

  • 1.  Histamine as a therapeutic target to dampen immune response in COVID-19

    Posted 04-10-2020 13:12
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    Can histamine be part of the reason why there is such a variability in immune response?   If so, then we can prime patients with a potent type 1 histamine receptor blocker which will decrease inflammation and allow more activation of immunosuppressing type 2 receptors.   The medication is levocetirizine and it had been shown to protect rats from lung damage in a 2018 LPS model study.   The drug is currently cheap and over the counter but most hospitals don't carry it because they have never had a need for it.

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    Michael Johnson
    PA (prior neurology research associate for UVA)
    Mary Washington Healthcare
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