During the November 2014 Annual Meeting of the Society of the Immunotherapy of Cancer, leaders in tumor immunology and cancer immunotherapy convened at the second annual SITC Primer to review both current knowledge and future directions in the field. Here, the authors will review the key discussions across a variety of topics, including innate immunity, adaptive immunity, dendritic cells, adoptive T cell therapy, anti-tumor antibodies, cancer vaccines, immune checkpoint blockade, challenges to immunotherapy, monitoring immune responses, and immunotherapy clinical trial design.Authors: Daivd B. Page, Ariel Bulua Bourla, Anthony Daniyan, Jarushka Naidoo, Eric Smith, Melody Smith, Claire Friedman, Danny N. Khalil, Samuel Funt, Alexander N. Shoushtari, Willem W. Overwijk, Padmanee Sharma and Margaret K. CallahanPublished as a meeting report in the Journal for ImmunoTherapy of Cancer (2015) 3:25.#SITCPublication