Summarized in this review are discussions from the 2013 SITC Primer, which focused on reviewing current knowledge and future directions of research related to tumor immunology and cancer immunotherapy, including sessions on innate immunity, adaptive immunity, therapeutic approaches (dendritic cells, adoptive T cell therapy, anti-tumor antibodies, cancer vaccines, and immune checkpoint blockade), challenges to driving an anti-tumor immune response, monitoring immune responses, and the future of immunotherapy clinical trial design.Authors: Raju R. Raval, Andrew B. Sharabi, Amanda J. Walker, Charles G. Drake and Padmanee SharmaPublished as a review in the Journal for ImmunoTherapy of Cancer (2014) 2:14.#SITCPublication