SITC Resource Library

On August 12, 2021, leading experts from the SITC Immune Effector Cell-related Adverse Events Guideline Expert Panel presented the "SITC Clinical Practice Guideline Webinar – Practical Management Pearls for Immune Effector Cell-related Adverse Events." This high-level webinar covered advanced concepts of toxicity management and risk factors drawing from recommendations within the Clinical Practice Guideline (CPG). The recorded webinar and presentation slides are available below.

Webinar Faculty:

• Moderator: Stephan Grupp, MD, PhD — Children’s Hospital of Philadelphia and University of Pennsylvania (Expert Panel Chair)
• Jorg Dietrich, MD, PhD — Massachusetts General Hospital (Expert Panel Member)
• Saatva S. Neelapu, MD — The University of Texas MD Anderson Cancer Center (Expert Panel Member)

The webinar discussed management and grading of toxicities associated with CAR T therapies and their risk factors, including:

• Cytokine release syndrome (CRS)
• Cardiovascular toxicities
• Immune effector cell-associated neurotoxicity syndrome (ICANS)
• Cerebral edema

Disclaimer: Due to the rapidly-evolving field of cancer immunotherapy, some of the content on this page may be out of date. For current information from SITC on cancer immunotherapy, please visit connected.sitcancer.org.

This webinar is supported, in part, by independent medical education grant funding from Amgen and Merck & Co., Inc.
The SITC Clinical Practice Guidelines are produced by SITC and have no funding from outside sources.