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SITC 29th Annual Meeting (2014): Richard V. Smalley, MD Memorial Lectureship: Cancer as a Disease of the Metaorganism 

02-20-2017 12:38

SITC 29th Annual Meeting: Richard V. Smalley, MD Memorial Lectureship - Cancer as a Disease of the Metaorganism
November 7-9, 2014
Gaylord National Hotel & Convention Center National Harbor, MD

SITC 29th Annual Meeting Organizers
Arthur A. Hurwitz, PhD - National Cancer Institute
Kim A. Margolin, MD - Stanford University
Daniel E. Speiser, MD - Ludwig Center for Cancer Research of the University of Lausanne
Walter J. Urba, MD, PhD - Earle A. Chiles Research Institute

Program Summary
About the Richard V. Smalley, MD Memorial Award: Established in 2005, the Richard V. Smalley, MD Memorial Award is presented each year to a luminary in the field that has significantly contributed to the advancement of cancer immunotherapy research. This award serves to honor those that have been pioneers in their work and made a notable impact worthy of high regard and recognition by their peers. Named in memory of former Society President and SITC charter member, Richard V. Smalley, MD, this is the Society's most prestigious award.

About the SITC 29th Annual Meeting
The SITC 29th Annual Meeting provided a multidisciplinary educational and interactive environment focused on improving outcomes for current and future patients with cancer by incorporating strategies based on basic and applied cancer immunotherapy. The meeting consisted of cutting-edge research presentations by experts in the field, oral and poster abstract presentations, and ample opportunities for structured and informal discussions, including important networking opportunities. In addition, the meeting included updates on major national and international initiatives coming from academia, government and industry, as well as important society projects.

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Cancer as a Disease of the Metaorganism Presentation Slides   8.97 MB   1 version
Uploaded - 02-20-2017
Meeting: SITC 29th Annual Meeting; Session: Richard V. Smalley, MD Memorial Lectureship: Cancer as a Disease of the Metaorganism; Presentation: Cancer as a Disease of the Metaorganism; Presenter: Giorgio Trinchieri, MD – National Cancer Institute; Date: November 7, 2014
 
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Comments

David Wolfgang
06-10-2017 09:16

The "Cancer as a Disease of the Metaorganism" presentation recognizes that human cells act as sensors for environmental changes. Aging can induce modulation of immune cell properties from resultant physiological or damaged-induced changes in the somatic environment. Exposure to high chronic doses to antigen can lead to adaptive lymphocyte changes rendering them refractory to further stimulation. But these cells, actually, should not be considered exhausted as they can modify their immediate environmental resources. Intervening to prevent or revert these adapted cells is what has led, in effect, to development of new cancer immunotherapy strategies.