Profiling of the immune receptor repertoire is becoming increasingly relevant to the understanding and clinical management of cancer, autoimmunity, aging, and infectious disease. A platform technology is described that provides comprehensive immune receptor profiling. The authors conclude that immunosequencing is a platform technology that allows the enumeration, specification and quantification of each and every B-and/or T-cell in any biologic sample of interest. It is based on bias-controlled multiplex PCR and high throughput sequencing and is highly accurate, standardized, and sensitive.Author: Ilan KirschPublished as a short report in the Journal for ImmunoTherapy of Cancer (2015) 3:29.#SITCPublication