SITC Archive Library

2016 Workshop on Challenges, Insights, and Future Directions for Mouse and Humanized Models in Cancer Immunology and Immunotherapy 

02-13-2017 15:44

The Society for Immunotherapy of Cancer (SITC) hosted the 2016 Workshop on Challenges, Insights, and Future Directions for Mouse and Humanized Models in Cancer Immunology and Immunotherapy during the 2016 Annual Meeting & Associated Programs on November 10, 2016. Available here are the presentation slides and video from the workshop.

Program Organizers

  • Marcus Bosenberg, PhD – Yale Cancer Center
  • Karolina Palucka, MD, PhD – The Jackson Laboratory for Genomic Medicine
  • Andrew Zloza, MD, PhD – Rutgers Cancer Institute of New Jersey

Program Summary

As the field of cancer immunotherapy continues to expand, it is important to address how models can best inform the future of immune drug development and aid us in understanding the mechanisms underlying anti-tumor immune responses. This workshop at the SITC 2016 Annual Meeting & Associated Programs on November 10, 2016 in National Harbor, MD provided a comprehensive discussion to address current strengths and weaknesses of a variety of models, approaches towards improving the predictive value of mouse models, and advances in cancer modeling that are anticipated in the near future. The program began with an introduction and overview of the most common immune competent (mouse-in-mouse) and human xenograft (humanized mouse) models used in cancer immunology and immunotherapy research. A special focus was placed on how to accurately model the tumor immune microenvironment. Further, the program discussed the use of models in the evaluation of immune therapies, specifically focusing on immune checkpoint inhibitors and combinations of small molecule inhibitors. Lastly, the workshop concluded with an open discussion regarding future directions for the development and use of cancer immune models.

Target Audience

The intended audience for this annual, one-day program included basic scientists and clinical investigators from academic institutions, industry and regulatory agencies. Additional audiences benefiting from this program included clinicians, graduate students, and postdoctoral fellows involved in cancer research and its translation into clinical practice. 

Disclaimer: Due to the rapidly-evolving field of cancer immunotherapy, some of the content on this page may be out of date. For current information from SITC on cancer immunotherapy, scroll down to view Related Entries and Links.

#Video#2016#AnnualMeeting#SITC#PresentationSlides#ClinicalTrials
#BrainCancers#BreastCancers#GastrointestinalCancers#Leukemia
#Melanoma#NonSmallCellLungCancer#RenalCellCarcinoma
#AdoptiveCellTherapy#Cytokines#ImmuneCheckpointInhibitors
#Pembrolizumab#Vaccines#Clinician#Industry#Oncologist#Researcher

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 Video
Attachment(s)
pdf file
"Major Questions Related to Immunotherapies that Require ...   1.13 MB   1 version
Uploaded - 02-13-2017
Meeting: 2016 Workshop on Challenges, Insights, and Future Directions for Mouse and Humanized Models in Cancer Immunology and Immunotherapy; Session: Introduction to Models of Immunotherapy; Presenter: Mario Sznol, MD – Yale School of Medicine; Date: November 10, 2016
mp4 file
"Major Questions Related to Immunotherapies that Require ...   222.41 MB   1 version
Uploaded - 02-14-2017
Meeting: 2016 Workshop on Challenges, Insights, and Future Directions for Mouse and Humanized Models in Cancer Immunology and Immunotherapy; Session: Introduction to Models of Immunotherapy; Presenter: Mario Sznol, MD – Yale School of Medicine; Date: November 10, 2016
pdf file
"Overview of Mouse-Mouse Models" - Presentation Slides   1.33 MB   1 version
Uploaded - 02-13-2017
Meeting: 2016 Workshop on Challenges, Insights, and Future Directions for Mouse and Humanized Models in Cancer Immunology and Immunotherapy; Session: Introduction to Models of Immunotherapy; Presenter: Marcus W. Bosenberg, MD, PhD – Yale School of Medicine; Date: November 10, 2016
mp4 file
"Overview of Mouse-Mouse Models" - Video   307.73 MB   1 version
Uploaded - 02-14-2017
Meeting: 2016 Workshop on Challenges, Insights, and Future Directions for Mouse and Humanized Models in Cancer Immunology and Immunotherapy; Session: Introduction to Models of Immunotherapy; Presenter: Marcus W. Bosenberg, MD, PhD – Yale School of Medicine; Date: November 10, 2016
pdf file
"Overview of Humanized Mice Models" - Presentation Slides   6.23 MB   1 version
Uploaded - 02-13-2017
Meeting: 2016 Workshop on Challenges, Insights, and Future Directions for Mouse and Humanized Models in Cancer Immunology and Immunotherapy; Session: Introduction to Models of Immunotherapy; Presenter: A. Karolina Palucka, MD, PhD – The Jackson Laboratory for Genomic Medicine; Date: November 10, 2016
mp4 file
"Overview of Humanized Mice Models" - Video   291.97 MB   1 version
Uploaded - 02-14-2017
Meeting: 2016 Workshop on Challenges, Insights, and Future Directions for Mouse and Humanized Models in Cancer Immunology and Immunotherapy; Session: Introduction to Models of Immunotherapy; Presenter: A. Karolina Palucka, MD, PhD – The Jackson Laboratory for Genomic Medicine; Date: November 10, 2016
pdf file
"Evaluation of the Tumor Microenvironment" - Presentation...   4.99 MB   1 version
Uploaded - 02-13-2017
Meeting: 2016 Workshop on Challenges, Insights, and Future Directions for Mouse and Humanized Models in Cancer Immunology and Immunotherapy; Session: Modeling the Tumor Microenvironment; Presenter: Mark B. Headley, PhD – University of California San Francisco; Date: November 10, 2016
mp4 file
"Evaluation of the Tumor Microenvironment" - Video   307.58 MB   1 version
Uploaded - 02-14-2017
Meeting: 2016 Workshop on Challenges, Insights, and Future Directions for Mouse and Humanized Models in Cancer Immunology and Immunotherapy; Session: Modeling the Tumor Microenvironment; Presenter: Mark B. Headley, PhD – University of California San Francisco; Date: November 10, 2016
pdf file
"Developing New Immunotherapies in Preclinical Models and...   2.82 MB   1 version
Uploaded - 02-13-2017
Meeting: 2016 Workshop on Challenges, Insights, and Future Directions for Mouse and Humanized Models in Cancer Immunology and Immunotherapy; Session: Modeling the Tumor Microenvironment; Presenter: Elizabeth M. Jaffee, MD – The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins University; Date: November 10, 2016
mp4 file
"Developing New Immunotherapies in Preclinical Models and...   282.77 MB   1 version
Uploaded - 02-14-2017
Meeting: 2016 Workshop on Challenges, Insights, and Future Directions for Mouse and Humanized Models in Cancer Immunology and Immunotherapy; Session: Modeling the Tumor Microenvironment; Presenter: Elizabeth M. Jaffee, MD – The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins University; Date: November 10, 2016
pdf file
"What Information Provided by Models will Inform Immune D...   2.21 MB   1 version
Uploaded - 02-13-2017
Meeting: 2016 Workshop on Challenges, Insights, and Future Directions for Mouse and Humanized Models in Cancer Immunology and Immunotherapy; Session: Modeling the Tumor Microenvironment; Presenter: Philip Gotwals, PhD – Novartis Institutes for BioMedical Research, Inc.; Date: November 10, 2016
mp4 file
"What Information Provided by Models will Inform Immune D...   389.02 MB   1 version
Uploaded - 02-14-2017
Meeting: 2016 Workshop on Challenges, Insights, and Future Directions for Mouse and Humanized Models in Cancer Immunology and Immunotherapy; Session: Modeling the Tumor Microenvironment; Presenter: Philip Gotwals, PhD – Novartis Institutes for BioMedical Research, Inc.; Date: November 10, 2016