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2014 Workshop on Combination Immunotherapy: Where Do We Go From Here?

02-21-2017 14:36

From the Society for Immunotherapy of Cancer (SITC), these enduring materials from the 2014 Workshop on Combination Immunotherapy: Where Do We Go From Here? identifies the current challenges to implementation of combination immune-based therapies across multiple cancer indications and to identify potential solutions to improve the rational application of immunotherapy. Immune-profiling of the tumor microenvironment by multiple different approaches is currently being pursued as a means to guide the development and clinical application of combination immunotherapies. Immune-profiling prior to treatment may hold the key to elucidation of biomarkers predictive of response while immune-profiling of patients undergoing treatment may hold the key for identifying biomarkers indicative of favorable clinical response, thus providing a means for early intervention and modification of treatment regimens in patients who may not be responding. By participating in the workshop, participants interacted with clinicians and scientists at the forefront of the cancer immunotherapy field. Participants learned about the current barriers, the outstanding unaddressed questions, the current approaches and technologies being employed in the field, and future directions. Most importantly, participants had the opportunity to connect with leaders in the field to spark new collaborations to push the field forward.

The target audience for this program included basic scientists and clinical investigators from academic institutions, industry, and regulatory agencies. The audience included clinicians, translational and basic researchers, graduate students, and postdoctoral fellows involved in cancer research.

2014 Workshop on Combination Immunotherapy: Where Do We Go From Here?
November 6, 2014
Gaylord National Hotel & Convention Center
National Harbor, MD

Organizers:
Anna Carrizosa Anderson, PhD - Harvard Medical School
Drew M. Pardoll, MD, PhD - Johns Hopkins University
Mario Sznol, MD - Yale University
Dario A. A. Vignali, PhD - University of Pittsburgh

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Immune-Tumor Interactions to Guide Combination Therapies ...   5.39MB   1 version
Uploaded - 02-21-2017
Meeting: 2014 Workshop on Combination Immunotherapy: Where Do We Go From Here?; Session: Session I: Beyond the Inflamed/Non-Inflamed Classification of the Immune Microenvironment; Presentation: Immune-Tumor Interactions to Guide Combination Therapies; Presenter: Antoni Ribas, MD, PhD – University of California Los Angeles; Date: November 6, 2014
mp4 file
Immune-Tumor Interactions to Guide Combination Therapies ...   92.06MB   1 version
Uploaded - 03-22-2017
Meeting: 2014 Workshop on Combination Immunotherapy: Where Do We Go From Here?; Session: Session I: Beyond the Inflamed/Non-Inflamed Classification of the Immune Microenvironment; Presentation: Immune-Tumor Interactions to Guide Combination Therapies; Presenter: Antoni Ribas, MD, PhD – University of California Los Angeles; Date: November 6, 2014
pdf file
PD-L1 IHC in Clinical Decision-Making for Immune Checkpoi...   2.05MB   1 version
Uploaded - 02-21-2017
Meeting: 2014 Workshop on Combination Immunotherapy: Where Do We Go From Here?; Session: Session I: Beyond the Inflamed/Non-Inflamed Classification of the Immune Microenvironment; Presentation: PD-L1 IHC in Clinical Decision-Making for Immune Checkpoint Blockade; Presenter: Suzanne L. Topalian, MD – Johns Hopkins University; Date: November 6, 2014
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Targeting Tregs in Tumors Presentation Slides   4.40MB   1 version
Uploaded - 02-21-2017
Meeting: 2014 Workshop on Combination Immunotherapy: Where Do We Go From Here?; Session: Session III: How to Break Tumor-Induced Immune Suppression; Presentation: Targeting Tregs in Tumors; Presenter: Dario A. A. Vignali, PhD – University of Pittsburgh; Date: November 6, 2014
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Effects of Immunotherapy on the Tumor Microenvironment Pr...   10.18MB   1 version
Uploaded - 02-21-2017
Meeting: 2014 Workshop on Combination Immunotherapy: Where Do We Go From Here?; Session: Session III: How to Break Tumor-Induced Immune Suppression; Presentation: Effects of Immunotherapy on the Tumor Microenvironment; Presenter: Susan M. Kaech, PhD – Yale University; Date: November 6, 2014
mp4 file
Effects of Immunotherapy on the Tumor Microenvironment Pr...   102.07MB   1 version
Uploaded - 03-22-2017
Meeting: 2014 Workshop on Combination Immunotherapy: Where Do We Go From Here?; Session: Session III: How to Break Tumor-Induced Immune Suppression; Presentation: Effects of Immunotherapy on the Tumor Microenvironment; Presenter: Susan M. Kaech, PhD – Yale University; Date: November 6, 2014
pdf file
Molecular Mechanisms of T Cell Exhaustion Presentation Sl...   3.83MB   1 version
Uploaded - 02-21-2017
Meeting: 2014 Workshop on Combination Immunotherapy: Where Do We Go From Here?; Session: Session III: How to Break Tumor-Induced Immune Suppression; Presentation: Molecular Mechanisms of T Cell Exhaustion; Presenter: E. John Wherry, PhD – University of Pennsylvania; Date: November 6, 2014
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Molecular Mechanisms of T Cell Exhaustion Presentation Video   90.50MB   1 version
Uploaded - 03-22-2017
Meeting: 2014 Workshop on Combination Immunotherapy: Where Do We Go From Here?; Session: Session III: How to Break Tumor-Induced Immune Suppression; Presentation: Molecular Mechanisms of T Cell Exhaustion; Presenter: E. John Wherry, PhD – University of Pennsylvania; Date: November 6, 2014
pdf file
Imprecision Medicine: Combination Immunotherapy Presentat...   1.24MB   1 version
Uploaded - 02-21-2017
Meeting: 2014 Workshop on Combination Immunotherapy: Where Do We Go From Here?; Session: Session III: How to Break Tumor-Induced Immune Suppression; Presentation: Imprecision Medicine: Combination Immunotherapy; Presenter: Mario Sznol, MD – Yale University; Date: November 6, 2014
mp4 file
Imprecision Medicine: Combination Immunotherapy Presentat...   70.27MB   1 version
Uploaded - 03-22-2017
Meeting: 2014 Workshop on Combination Immunotherapy: Where Do We Go From Here?; Session: Session III: How to Break Tumor-Induced Immune Suppression; Presentation: Imprecision Medicine: Combination Immunotherapy; Presenter: Mario Sznol, MD – Yale University; Date: November 6, 2014

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