SITC Resource Library

2014 Hot Topic Symposium II: Managing Engineered T Cell Toxicities

02-21-2017 15:45

From the Society for Immunotherapy of Cancer (SITC), these enduring materials from the 2014 Hot Topic Symposium II: Managing Engineered T Cell Toxicities review the safety experience with CAR T cells and engineered TCR T cells treating hematologic and solid tumor indications, with a specific focus on the unique toxicities described above. Faculty provided guidance on T cell engineering considerations, protocol eligibility restrictions, and special safety monitoring, grading and management guidelines to minimize risk associated with these novel T cell therapies. Organizers: Kristen Hege, MD – Celgene and University of California, San Francisco Peter Emtage, MD – Medimmune/AstraZeneca 2014 Hot Topic Symposium II: Managing Engineered T Cell Toxicities November 9, 2014 Gaylord National Hotel & Convention Center National Harbor, MD

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Welcome and Overview Presentation Slides   20K   1 version
Uploaded - 02-21-2017
Meeting: 2014 Hot Topic Symposium II: Managing Engineered T Cell Toxicities; Presentation: Welcome and Overview; Presenter: Kristen M. Hege, MD – Celgene Corporation and University of California, San Francisco; Date: November 9, 2014
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FDA – History of Immune-Related Adverse Effects from the ...   393K   1 version
Uploaded - 02-21-2017
Meeting: 2014 Hot Topic Symposium II: Managing Engineered T Cell Toxicities; Presentation: FDA – History of Immune-Related Adverse Effects from the Regulatory Perspective; Presenter: Bindu George, MD – U.S. Food and Drug Administration; Date: November 9, 2014
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FDA – History of Immune-Related Adverse Effects from the ...   41.21MB   1 version
Uploaded - 03-28-2017
Meeting: 2014 Hot Topic Symposium II: Managing Engineered T Cell Toxicities; Presentation: FDA – History of Immune-Related Adverse Effects from the Regulatory Perspective; Presenter: Bindu George, MD – U.S. Food and Drug Administration; Date: November 9, 2014
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Toxicity and Management after CTL019 Therapy: Update from...   777K   1 version
Uploaded - 02-21-2017
Meeting: 2014 Hot Topic Symposium II: Managing Engineered T Cell Toxicities; Presentation: Toxicity and Management after CTL019 Therapy: Update from University of Pennsylvania; Presenter: James N. Kochenderfer, MD – National Cancer Institute; Date: November 9, 2014
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Toxicity and Management after CTL019 Therapy: Update from...   77.65MB   1 version
Uploaded - 03-28-2017
Meeting: 2014 Hot Topic Symposium II: Managing Engineered T Cell Toxicities; Presentation: Toxicity and Management after CTL019 Therapy: Update from University of Pennsylvania; Presenter: James N. Kochenderfer, MD – National Cancer Institute; Date: November 9, 2014
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Anti-CD19 CAR T Cells: The Balance of Efficacy and Toxici...   193K   1 version
Uploaded - 02-21-2017
Meeting: 2014 Hot Topic Symposium II: Managing Engineered T Cell Toxicities; Presentation: Anti-CD19 CAR T Cells: The Balance of Efficacy and Toxicity; Presenter: James N. Kochenderfer, MD – National Cancer Institute; Date: November 9, 2014
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Anti-CD19 CAR T Cells: The Balance of Efficacy and Toxici...   60.16MB   1 version
Uploaded - 03-28-2017
Meeting: 2014 Hot Topic Symposium II: Managing Engineered T Cell Toxicities; Presentation: Anti-CD19 CAR T Cells: The Balance of Efficacy and Toxicity; Presenter: James N. Kochenderfer, MD – National Cancer Institute; Date: November 9, 2014
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Fred Hutchinson Cancer Research Center Experience Present...   2.17MB   1 version
Uploaded - 02-21-2017
Meeting: 2014 Hot Topic Symposium II: Managing Engineered T Cell Toxicities; Presentation: Fred Hutchinson Cancer Research Center Experience; Presenter: Michael C.V. Jensen, MD – University of Washington; Date: November 9, 2014
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Fred Hutchinson Cancer Research Center Experience Present...   40.02MB   1 version
Uploaded - 03-28-2017
Meeting: 2014 Hot Topic Symposium II: Managing Engineered T Cell Toxicities; Presentation: Fred Hutchinson Cancer Research Center Experience; Presenter: Michael C.V. Jensen, MD – University of Washington; Date: November 9, 2014
pdf file
Cytokine Storm in T Cell Studies - An Update from Baylor ...   451K   1 version
Uploaded - 02-21-2017
Meeting: 2014 Hot Topic Symposium II: Managing Engineered T Cell Toxicities; Presentation: Cytokine Storm in T Cell Studies - An Update from Baylor University; Presenter: Helen E. Heslop, MD – Baylor College of Medicine; Date: November 9, 2014
mp4 file
Cytokine Storm in T Cell Studies - An Update from Baylor ...   19.03MB   1 version
Uploaded - 03-28-2017
Meeting: 2014 Hot Topic Symposium II: Managing Engineered T Cell Toxicities; Presentation: Cytokine Storm in T Cell Studies - An Update from Baylor University; Presenter: Helen E. Heslop, MD – Baylor College of Medicine; Date: November 9, 2014

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