SITC Resource Library

2014 Hot Topic Symposium I: Accelerating Tumor Immunity with Agonist Antibodies

02-21-2017 15:32

From the Society for Immunotherapy of Cancer (SITC), these enduring materials from the 2014 Hot Topic Symposium I: Accelerating Tumor Immunity with Agonist Antibodies address how activation of stimulatory receptors on both T cells and antigen presenting cells can enhance tumor immunity both in animal models and in clinical trials.

Tumors locally attenuate T cells through engagement of co-inhibitory receptors, as well as by depriving their microenvironment of the positive co-stimulation signals necessary for these cells to robustly expand and acquire high-levels of effector function. Antibodies which block immune checkpoint receptors have proven capable of extending survival and inducing tumor regression in patients suffering from a variety of metastatic cancers leading to FDA approval for Ipilimumab (a-CTLA-4) in 2011 and likely approval of multiple PD-1 blocking antibodies in the coming months. In contrast, antibodies designed to activate co-stimulatory receptors on T cells and/or antigen-presenting cells to promote enhanced survival, proliferation, and effector function have yet to move beyond early phase clinical trials despite profound therapeutic efficacy in pre-clinical models.

The development of these promising immunotherapeutic agonists has been slowed by limited understanding of their underlying mechanisms of action and, in many cases, the resulting inability to separate off-target toxicity from on-target anti-tumor immunity. Recent discoveries illuminating the detailed immunobiology of existing agonist antibodies such as a-CD40 and a-4-1BB, coupled with new agonists targeting OX40 and CD27 into the clinic, has renewed optimism that these agents will show the therapeutic promise they have displayed in animal models. This symposium addressed how activation of stimulatory receptors on both T cells and antigen presenting cells can enhance tumor immunity both in animal models and in clinical trials.

2014 Hot Topic Symposium I: Accelerating Tumor Immunity with Agonist Antibodies
November 6, 2014
Gaylord National Hotel & Convention Center
National Harbor, MD

Organizers:
Michael A. Curran, PhD –University of Texas, MD Anderson Cancer Center
Ronald Levy, MD – Stanford University
Andrew D. Weinberg, PhD – Earle A. Chiles Research Institute, Providence Portland Medical Center

Statistics
0 Favorited
42 Views
8 Files
0 Shares
471 Downloads
Attachment(s)
pdf file
T Cell Costimulation in Cancer Immunotherapy through Agon...   1.57MB   1 version
Uploaded - 02-21-2017
Meeting: Hot Topic Symposium I: Accelerating Tumor Immunity with Agonist Antibodies; Presentation: T Cell Costimulation in Cancer Immunotherapy through Agonist Agents: OX40; Presenter: Andrew D. Weinberg, PhD – Earle A. Chiles Research Institute, Providence Portland Medical Center; Date: November 9, 2014
mp4 file
T Cell Costimulation in Cancer Immunotherapy through Agon...   83.97MB   1 version
Uploaded - 03-28-2017
Meeting: Hot Topic Symposium I: Accelerating Tumor Immunity with Agonist Antibodies; Presentation: T Cell Costimulation in Cancer Immunotherapy through Agonist Agents: OX40; Presenter: Andrew D. Weinberg, PhD – Earle A. Chiles Research Institute, Providence Portland Medical Center; Date: November 9, 2014
pdf file
4-1BB: Enhancing Innate and Adaptive Immunity Presentatio...   16.48MB   1 version
Uploaded - 02-21-2017
Meeting: Hot Topic Symposium I: Accelerating Tumor Immunity with Agonist Antibodies; Presentation: 4-1BB: Enhancing Innate and Adaptive Immunity; Presenter: Holbrook E. Kohrt, MD, PhD – Stanford Cancer Institute; Date: November 9, 2014
mp4 file
4-1BB: Enhancing Innate and Adaptive Immunity Presentatio...   91.83MB   1 version
Uploaded - 03-28-2017
Meeting: Hot Topic Symposium I: Accelerating Tumor Immunity with Agonist Antibodies; Presentation: 4-1BB: Enhancing Innate and Adaptive Immunity; Presenter: Holbrook E. Kohrt, MD, PhD – Stanford Cancer Institute; Date: November 9, 2014
pdf file
Anti-CD40 Agonist Antibody - The Ideal Combination Partne...   2.61MB   1 version
Uploaded - 02-21-2017
Meeting: Hot Topic Symposium I: Accelerating Tumor Immunity with Agonist Antibodies; Presentation: Anti-CD40 Agonist Antibody - The Ideal Combination Partner for Cancer Immunotherapy; Presenter: Hy Levitsky, MD – Roche Glycart AG; Date: November 9, 2014
mp4 file
Anti-CD40 Agonist Antibody - The Ideal Combination Partne...   60.16MB   1 version
Uploaded - 03-28-2017
Meeting: Hot Topic Symposium I: Accelerating Tumor Immunity with Agonist Antibodies; Presentation: Anti-CD40 Agonist Antibody - The Ideal Combination Partner for Cancer Immunotherapy; Presenter: Hy Levitsky, MD – Roche Glycart AG; Date: November 9, 2014
pdf file
Oligonucleotide Aptamers: A Novel Drug and Drug Delivery ...   1.19MB   1 version
Uploaded - 02-21-2017
Meeting: Hot Topic Symposium I: Accelerating Tumor Immunity with Agonist Antibodies; Presentation: Oligonucleotide Aptamers: A Novel Drug and Drug Delivery Platform for Cancer Immunotherapy; Presenter: Eli Gilboa, PhD – University of Miami; Date: November 9, 2014
mp4 file
Oligonucleotide Aptamers: A Novel Drug and Drug Delivery ...   45.92MB   1 version
Uploaded - 03-28-2017
Meeting: Hot Topic Symposium I: Accelerating Tumor Immunity with Agonist Antibodies; Presentation: Oligonucleotide Aptamers: A Novel Drug and Drug Delivery Platform for Cancer Immunotherapy; Presenter: Eli Gilboa, PhD – University of Miami; Date: November 9, 2014

Tags and Keywords

Related Entries and Links

No Related Resource entered.