Case Report
Jared R. Lowe, Daniel J. Perry, April K. S. Salama, Clayton E. Mathews, Larry G. Moss and Brent A. Hanks
Journal for ImmunoTherapy of Cancer 2016, 4:89 (20 December 2016)
From the Authors
"The ability to predict the development of toxicities to checkpoint inhibitors represents a clinically meaningful goal in the field of cancer immunotherapy. We describe a genetic risk assessment based on HLA alleles and single nucleotide polymorphisms of a patient following the development of fulminant autoimmune type I diabetes while undergoing combination ipilimumab/nivolumab immunotherapy."
Brent A. Hanks, MD, PhD — Duke University Medical Center
Joshua E. Reuss, Paul R. Kunk, Anne M. Stowman, Alejandro A. Gru, Craig L. Slingluff Jr. and Elizabeth M. Gaughan
Journal for ImmunoTherapy of Cancer 2016, 4:94 (20 December 2016)
From the Authors
"With the routine use of combination and sequential checkpoint inhibitor therapy, providers are challenged to interpret and manage varied responses. Tissue biopsy of new lesions developing while a patient is receiving immunotherapy is an important step to help guide decision making, as non-melanoma lesions can mimic disease progression."
Elizabeth M. Gaughan, MD — University of Virginia
Commentary
William J. Murphy
Journal for ImmunoTherapy of Cancer 2016, 4:88 (20 December 2016)
From the Author
"Immunotherapy is increasingly applied as a mainstream cancer regimen yet its strength – the ability to amplify and sustain responses – can also be a drawback with regard to off-target effects. There is a critical need to develop and use preclinical models that better emulate human immune status in cancer."
William J. Murphy, PhD — University of California, Davis
Dustin A. Deming
Journal for ImmunoTherapy of Cancer 2016, 4:93 (20 December 2016)
From the Author
"Here we provide commentary on a manuscript from Halama et al. examining CCL5/CCR5 as an immune biomarker and the potential role of anti-CCR5 agents for the treatment of patients with colorectal cancer."
Excerpt from Article Abstract
Eli Gilboa
Journal for ImmunoTherapy of Cancer 2016, 4:87 (20 December 2016)
From the Author
"In a recent article in Nature, Kranz and colleagues describe what appears to be a remarkably effective and relatively simple approach, using tumor antigen-encoding mRNA complexed to cationic lipid carriers, RNA-lipoplexes. Amazingly, all it took was to tweak the net charge of the RNA to lipid ratio to be slightly negative."
Eli Gilboa, PhD — University of Miami
Position Article & Guidelines
Douglas G. McNeel, Neil H. Bander, Tomasz M. Beer, Charles G. Drake, Lawrence Fong, Stacey Harrelson, Philip W. Kantoff, Ravi A. Madan, William K. Oh, David J. Peace, Daniel P. Petrylak, Hank Porterfield, Oliver Sartor, Neal D. Shore, Susan F. Slovin, Mark N. Stein, Johannes Vieweg and James L. Gulley
Journal for ImmunoTherapy of Cancer 2016, 4:92 (20 December 2016)
From the Authors
"These consensus guidelines provide guidance for the use of sipuleucel-T, currently the only approved immunotherapy in prostate cancer, and lay the groundwork for the development and subsequent clinical implementation of novel immune-based agents currently being explored in prostate cancer. We look forward to updating these guidelines as new immunotherapy agents are approved for patients with prostate cancer."
James L. Gulley, MD, PhD, FACP — National Cancer Institute
Michael Boyiadzis, Michael R. Bishop, Rafat Abonour, Kenneth C. Anderson, Stephen M. Ansell, David Avigan, Lisa Barbarotta, Austin John Barrett, Koen Van Besien, P. Leif Bergsagel, Ivan Borrello, Joshua Brody, Jill Brufsky, Mitchell Cairo, Ajai Chari, Adam Cohen, Jorge Cortes, Stephen J. Forman, Jonathan W. Friedberg, Ephraim J. Fuchs, Steven D. Gore, Sundar Jagannath, Brad S. Kahl, Justin Kline, James N. Kochenderfer, Larry W. Kwak, Ronald Levy, Marcos de Lima, Mark R. Litzow, Anuj Mahindra, Jeffrey Miller, Nikhil C. Munshi, Robert Z. Orlowski, John M. Pagel, David L. Porter, Stephen J. Russell, Karl Schwartz, Margaret A. Shipp, David Siegel, Richard M. Stone, Martin S. Tallman, John M. Timmerman, Frits Van Rhee, Edmund K. Waller, Ann Welsh, Michael Werner, Peter H. Wiernik and Madhav V. Dhodapkar
Journal for ImmunoTherapy of Cancer 2016, 4:90 (20 December 2016)
From the Authors
"This document provides the first consensus opinion on the application of current and emerging immune-based approaches in the management of hematologic malignancies. SITC should be congratulated for engaging clinical and research leaders in this field, as well as patient and nursing advocates and SITC membership for generating this important evidence-based document."
Madhav Dhodapkar, MD — Yale University
Research Article
James T. Gordy, Kun Luo, Hong Zhang, Arya Biragyn and Richard B. Markham
Journal for ImmunoTherapy of Cancer 2016, 4:96 (20 December 2016)
From the Authors
"Although therapeutic cancer vaccines have been mostly disappointing in the clinic, the advent of novel immunotherapies and the future promise of neoantigen-based therapies have created the need for new vaccine modalities that can easily adapt to current and future developments in cancer immunotherapy."
Excerpt from Article Abstract
Mizuki Nishino, Nikhil H. Ramaiya, Emily S. Chambers, Anika E. Adeni, Hiroto Hatabu, Pasi A. Jänne, F. Stephen Hodi and Mark M. Awad
Journal for ImmunoTherapy of Cancer 2016, 4:84 (20 December 2016)
From the Authors
"Immune-related response evaluations using irRECIST1.1 in advanced non-small cell lung cancer patients treated with nivolumab resulted in the identical response rate to the conventional RECIST1.1, with no pseudoprogression cases during the study. Adrenal lesions and lymph nodes were more responsive and liver lesions were less responsive to nivolumab, indicating the impact of tumor microenvironments in different organs on immune-related tumor response."
Mizuki Nishino, MD, MPH — Dana-Farber Cancer Institute
Andrew S. Brohl, Nikhil I. Khushalani, Zeynep Eroglu, Joseph Markowitz, Ram Thapa, Y. Ann Chen, Ragini Kudchadkar and Jeffrey S. Weber
Journal for ImmunoTherapy of Cancer 2016, 4:85 (20 December 2016)
From the Authors
"In our 31 patient study, we report the feasibility of treatment with the combination of ipilimumab and peginterferon alfa-2b in the setting of advanced melanoma. A promising efficacy signal was observed, with 40% of patients experiencing an objective response to treatment."
Andrew S. Brohl, MD — H. Lee Moffitt Cancer Center
Review
Jie Deng, Isabelle Le Mercier, Anna Kuta and Randolph J. Noelle
Journal for ImmunoTherapy of Cancer 2016, 4:86 (20 December 2016)
From the Authors
"As combination immunotherapy continues to rise to the forefront of cancer treatment, we discuss how the strategic combination of current established NCR with anti-VISTA antibody can be used to target non-redundant pathways."
Isabelle Le Mercier, PhD — ImmuNext, Inc.
Tycel Phillips, Sumana Devata and Ryan A. Wilcox
Journal for ImmunoTherapy of Cancer 2016, 4:95 (20 December 2016)
From the Authors
"The results achieved thus far with checkpoint blockade in T cell lymphomas, while encouraging, suggest that novel combination strategies will be needed to achieve durable remissions in patients afflicted with these aggressive non-Hodgkin lymphomas."
Ryan A. Wilcox, MD, PhD — University of Michigan
Jiwon S. Park, Sita S. Withers, Jaime F. Modiano, Michael S. Kent, Mingyi Chen, Jesus I. Luna, William T. N. Culp, Ellen E. Sparger, Robert B. Rebhun, Arta M. Monjazeb, William J. Murphy and Robert J. Canter
Journal for ImmunoTherapy of Cancer 2016, 4:97 (20 December 2016)
From the Authors
"There is a growing body of evidence that spontaneous cancers in dogs represent attractive translational models that bridge mechanistic studies in mice to the heterogeneous human situation where clinical trials are time and resource intensive and may deliver ambiguous results. Particularly in the burgeoning field of immunotherapy, dogs offer an innovative model for translational research, as they present many of the same challenges faced in “scaling up” a therapeutic system dependent on complex interactions between multiple cell types, while simultaneously allowing for long-term assessment of efficacy and toxicities."
Robert Canter, MD, MAS, FACS — University of California Davis Health System
November Highly Accessed Articles
Brian I. Rini, David F. McDermott, Hans Hammers, William Bro, Ronald M. Bukowski, Bernard Faba, Jo Faba, Robert A. Figlin, Thomas Hutson, Eric Jonasch, Richard W. Joseph, Bradley C. Leibovich, Thomas Olencki, Allan J. Pantuck, David I. Quinn, Virginia Seery, Martin H. Voss, Christopher G. Wood, Laura S. Wood and Michael B. Atkins
Journal for ImmunoTherapy of Cancer 2016 4:81 (15 November 2016)
Giuseppe V. Masucci, Alessandra Cesano, Rachael Hawtin, Sylvia Janetzki, Jenny Zhang, Ilan Kirsch, Kevin K. Dobbin, John Alvarez, Paul B. Robbins, Senthamil R. Selvan, Howard Z. Streicher, Lisa H. Butterfield and Magdalena Thurin
Journal for ImmunoTherapy of Cancer 2016 4:76 (15 November 2016)