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Updated Content
In accordance with the Institute of Medicine’s Standards for Developing Trustworthy Clinical Practice Guidelines, SITC CPGs undergo periodic evaluation to assess if new evidence necessitates modifications to recommendations, treatment algorithms, or other guideline content. This is done through our “SITC Living Guidelines” rapid update protocols designed to ensure SITC CPGs are up-to-date with cutting-edge thinking and incorporate the leading expert guidance in cancer immunotherapy care – a vital service to treating clinicians and those along the whole cancer care continuum.
The information below provides an overview of the updates made to "The Society for Immunotherapy of Cancer consensus statement on immunotherapy for the treatment of multiple myeloma" since its publication in Journal for ImmunoTherapy of Cancer (JITC).
Rapid Update v1.3 Summary
- Based on the FDA approval of daratumumab in combination with carfilzomib and dexamethasone for adult patients with relapsed or refractory multiple myeloma who have received 1 to 3 prior lines of therapy on November 30, 2021, the Multiple Myeloma CPG has been updated in the following locations: "Monoclonal Antibodies Expert Panel Recommendations," and "Multiple Myeloma Key Monoclonal Antibody Therapies Trials."
Rapid Update v1.2 Summary
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Based on the approval of idecabtagene vicleucel for the treatment of adult patients with relapsed or refractory multiple myeloma after four or more prior lines of therapy, including an immunomodulatory agent, a proteasome inhibitor, and an anti-CD38 monoclonal antibody, the Multiple Myeloma CPG has been updated in the following locations: "Background," and "CAR T Cell Therapies."
Rapid Update v1.1 Summary
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Based on the accelerated approval of belantamab mafodotin-blmf for adult patients with relapsed or refractory multiple myeloma who have received at least 4 prior therapies, including an anti-CD38 monoclonal antibody, a proteasome inhibitor, and an immunomodulatory agent, the Multiple Myeloma CPG was updated in the following locations: "Antibody-Drug Conjugates," and "Background."
Version 2.0 Coming Soon
A complete update of this guideline is currently in development; SITC Multiple Myeloma Clinical Practice Guideline v2.0 is expected to publish in early 2025.