Mechanisms of Immune-Related Adverse Events: Module 9 of 12


It is important to note there are twelve ACI online modules, you are currently reviewing module nine. You may complete any of the modules in the order you choose. Each module can be completed independently for continuing education credit. 

The Mechanisms of Immune-Related Adverse Events module covers the inflammatory reaction produced by immune system responses, differences in adverse events compared to cytotoxic chemotherapy and targeted agents, and the timing of various immune toxicities.

Module 9
Justine V. Cohen, DO – Massachusetts General Hospital

Educational Objectives
  • Explain basic principles of immunological tolerance and autoimmunity
  • Discuss the differential roles of CTLA-4 and PD-1 in maintenance of tolerance
  • Describe mechanisms of breakdown of tolerance by checkpoint blockade

Target Audience

The ACI 2017 video series have been designed to meet the educational needs of physicians, pharmacists, registered nurses and other healthcare professionals involved in the care of patients with cancer.

Related Class Content

All modules offer Continuing Education (CE) Credit

Register/Access Class

Target Audience
Clinician Icon

Credit Available
Oct. 6, 2017- Sept. 30, 2018

  • CME: 0.5 AMA PRA Category 1 Credit(s)™
  • CNE: 0.4 contact hours
  • CPE: 0.5 contact hours (0.05 CEUs)

Approximate Time to Complete
0.5 hours


Please use one of the following Internet browsers to open this activity: Chrome, Firefox, or Safari browsers in order to view this online activity.

Jointly provided by Postgraduate Institute for Medicine and the Society for Immunotherapy of Cancer 

The 2017 Advances in Cancer Immunotherapy™ series is supported in part by independent medical educational grants from 
Aduro Biotech, Inc., Amgen, AstraZeneca Pharmaceuticals LP, Bristol-Myers Squibb, Merck & Co., Inc. and Prometheus Laboratories Inc.