The Society for Immunotherapy of Cancer (SITC) hosted Session 203 during the 39th Annual Meeting & Pre-Conference Programs on Saturday, November 9, 2024. Available here are the presentation slides and video from “Session 203: Genomic Instability: How it Mediates Immunity and Immune Evasion” as permitted by presenters.
David A. Braun, MD, PhD – Yale School of Medicine
Genomic instability is a core feature of cancer evolution, but beyond tumor-intrinsic effects, it can also contribute to pro- or anti-tumor immune responses. Genomic instability leading to DNA damage and mutations increase the potential neoantigen burden and may therefore contribute positively to anti-tumor immunity. By contrast, chromosomal instability may lead to chronic activation of innate and adaptive immune pathways, ultimately mediating immune evasion by tumor cells. This session will focus on the role of understanding chromosomal instability in cancer evolution in the clinic, and then dive into the mechanistic underpinnings of how chromosomal instability and chronic interferon signaling may facilitate immune evasion and resistance to current immunotherapies.
To view the entire program schedule (including presenter permission to post) please click here.
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