Initiative OverviewPathology and specific multiplex imaging, which allows for simultaneous characterization of multiple markers, has been more readily investigated and is envisioned to be critical for the selection of novel therapeutics in the future. Clinical adoption of these technologies, however, remains limited due to various challenges including standardized data reporting methods. To address this barrier in the field, the
SITC Pathology Committee has proposed holding a Multiplex Immunofluorescence – Special Interest Group (MxIF-SIG) Initiative. The primary goal of this initiative is to develop a consensus checklist for multiplex IF and immune histochemistry (IHC) data validation and reporting.
Over the next few months, the MxIF-SIG Initiative Organizers and 50+ invited stakeholders will meet virtually, through a number of smaller working group meetings, to discuss the development of the consensus checklist.
During these smaller meetings, participants will have the chance to look up close at a specific portion of the checklist to discuss necessary changes and requirements. When a consensus within each working group is met, all stakeholders will reconvene to discuss their findings and finalize the checklist.
MxIF-SIG Initiative Working Groups:
- Data Analysis and Presentation
- General (Overview)
- Image Acquisition
- Image Analysis
- Tissue Staining and Processing