The Society of Interventional Radiology (SIR) is a nonprofit, professional medical society representing more than 8,000 practicing interventional radiology physicians, trainees, medical students, scientists and clinical associates, including physician assistants, nurse practitioners, radiologic technologists and paramedical professionals. SIR’s members work in a variety of settings and at different professional levels—from medical students and residents to university faculty and private practice physicians. The society’s core purpose and mission is to work with its members to deliver patient-centered care through image-guided therapy.Wednesday Closing Plenary Session: Act Local, Think Global: IR and its role in Immuno-oncology Schedule:March 8th, 10:30 a.m. – 12:00 p.m.Moderators: Rahul A. Sheth, MD - The University of Texas MD Anderson Cancer CenterDaniel B. Brown, MD - Vanderbilt University Medical CenterDescription:This plenary session will highlight the potential roles of Interventional Radiology in the contemporary era of Immuno-Oncology. While immunotherapy has revolutionized cancer care, there are substantial unmet needs for which IR is in many ways ideally suited to address. Topics addressed in this plenary session will include barriers to immune checkpoint inhibition and in particular the role of the liver and liver metastases in suppressing tumor immunity. Hot topics in immuno-oncology including cell-based therapies, novel targeted therapies, and intratumoral immunotherapies will also be discussed.