Biomarkers Special Interest Group

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last person joined: 2 days ago 

Given the rapid growth and success of immunotherapy in cancer care, the next challenges lie in discovering new targets, predicting patient response, reducing toxicities, and optimizing therapeutic strategies. Central to overcoming these challenges is bioinformatics—the application of computational, statistical, and genomic tools to understand the immune system and guide the development of next‑generation immunotherapies.
The SITC Immunotherapy Bioinformatics Special Interest Group (SIG) welcomes all SITC members interested in leveraging bioinformatics to drive these advances. The SIG offers a collaborative space for researchers, clinicians, data scientists, and industry professionals to connect with peers, share expertise, and help shape the future of immunotherapy.

  • 1.  Pipeline Updates

    Posted an hour ago

    Have you had a chance to look at the new pipeline updates for predicting neoantigen stability? The latest models are starting to incorporate MHC–peptide complex dynamics instead of just affinity scores.



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    Lucy Macek
    Communications and Membership Coordinator
    SITC
    Milwaukee WI
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  • 2.  RE: Pipeline Updates

    Posted an hour ago
    Yes! And what's interesting is how much the stability predictions change once you factor in antigen processing features. It's giving us a clearer picture of which candidates might drive actual T‑cell responses.


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    William Wesolowski MS
    Project Manager-Membership
    SITC
    Milwaukee WI
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    Original Message


  • 3.  RE: Pipeline Updates

    Posted an hour ago

     Exactly. I'm thinking our SIG could run a small benchmarking project-compare the new predictors on a shared dataset and see if any of them hold up across tumor types.



    ------------------------------
    Lucy Macek
    Communications and Membership Coordinator
    SITC
    Milwaukee WI
    ------------------------------

    Original Message


  • 4.  RE: Pipeline Updates

    Posted an hour ago
    Count me in. It'd be great to have a community-driven evaluation instead of relying on individual papers with different assumptions!


    ------------------------------
    William Wesolowski MS
    Project Manager-Membership
    SITC
    Milwaukee WI
    ------------------------------

    Original Message


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