Draft Manuscript Summary
Immune checkpoint inhibitors (ICIs) have revolutionized cancer therapy, offering durable responses and prolonged survival. However, these therapies also present unique challenges, particularly with the onset of immune-related adverse events (irAEs), which can emerge during treatment either acutely and/or become chronic, or present long after treatment cessation. Delayed, chronic, and re-emergent irAEs often require nuanced survivorship care, including coordination across oncology, specialty care, and primary care. Despite the increased usage of these agents, there is limited longitudinal data guiding the surveillance, attribution, diagnosis, and management of irAEs after ICI treatment.
To address these gaps, the Society for Immunotherapy of Cancer (SITC) convened an Expert Panel to discuss best practices and identify research opportunities for improving post-treatment care. This manuscript outlines these expert insights into irAE surveillance, care transitions, and management strategies, emphasizing the importance of clinicians understanding irAE onset patterns, multidisciplinary coordination, and the urgent need in the field for the development of a comprehensive irAE registry. By addressing these critical gaps, the oncology community can better support the growing population of ICI-treated cancer survivors, ensuring improved quality of life and care outcomes.