Over the course of 2024, the Global Access and Impact Committee worked to develop a manuscript titled “Cancer Immunotherapy Clinical Trials to Support Urgently Needed Access in Low and Middle-Income Countries: A Report from the SITC Global Access and Impact Committee”. The goal of this text is to discuss learnings from clinical trials and demonstration projects of checkpoint blockade immunotherapy around the world, with an emphasis on low- and middle-income economies (LMIEs), as well as provide recommendations for future studies. These recommendations instruct readers on how to drive towards patient impact by generating data that will educate local stakeholders, including patients, providers, regulators, professional societies, and payors. This manuscript demonstrates how clinical trials in resource-limited settings have the power to impact future IO development. As of early December 2024, the manuscript was submitted to JITC and is currently under consideration for publication.