SU2C-SITC Convergence Scholar Award 3

SU2C-Lustgarten Foundation Convergence Research Team: Computational Deconstruction of Neoantigen-TCR Degeneracy for Cancer Immunotherapy

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Team Leaders

Benjamin Greenbaum, PhD
Icahn School of Medicine at Mount Sinai Hospital
Vinod Balachandran, MD
Memorial Sloan Kettering Cancer Center

Team Members

Marta Łuksza, PhD
Icahn School of Medicine at Mount Sinai
Eileen M. O’Reilly, MD
David M. Rubenstein Center for Pancreatic Cancer Research
Jedd Wolchok, MD, PhD
Memorial Sloan Kettering Cancer Center


Collaborators

Nina Bhardwaj, MD, PhD
Icahn School of Medicine at Mount Sinai
Curtis Callan, PhD
Princeton University
Timothy Chan, MD, PhD
Memorial Sloan Kettering Cancer Center
Simona Cocco, PhD
Ecole Normale Supérieure
Jeffrey Drebin, MD, PhD
Memorial Sloan Kettering Cancer Center
Anthony Gill, MD
Professor of Surgical Pathology, University of Sydney
Christine Iacobuzio-Donahue, MD, PhD
Memorial Sloan Kettering Cancer Center
Dmitry Krotov, PhD
Member, Institute for Advanced Study
Taha Merghoub, PhD
Memorial Sloan Kettering Cancer Center
Rémi Monasson, PhD
Centre National de la Recherche Scientifique
Thierry Mora
Ecole Normale Supérieure
Aleksandra Walczak, PhD
Ecole Normale Supérieure

Project Summary

The team will build on the work started under a prior SU2C Convergence grant but further explore the underpinnings that constitute pancreatic survivorship. By looking at the few individuals who survive pancreatic cancer for long periods of time, the team identified an initial set of high-quality neoantigens, or protein tags, on cancer cells that the immune system recognizes.  This project will continue the work to understand what makes a high-quality neoantigen and how the microbiome influences how the immune system recognizes it, with the goal of developing a method for creating vaccines to treat pancreatic cancers.  This research will have a significant impact on understanding neoantigen-T cell immunobiology and could improve the treatment prospects of pancreatic cancer patients.

Apply Now

To apply, send your CV, cover letter, and two letters of support to development@sitcancer.org. Please indicate the project to which you are applying.

Click here for more information regarding application requirements.

Applications due: Sept. 28, 2018

GENERAL INFORMATION

Details vary by project and institution, but the following applies to each opportunity
  • Full-time, multi-year commitment
  • Salary commensurate with experience and applicable policies
  • Fellowship will take place at either the Team Lead's institution or a partner institution
  • Additional eligibility criteria are determined by the Team Leads and host institutions