The Society for Immunotherapy of Cancer (SITC) cordially asks you to save the date of our 32nd Annual Meeting & Pre-Conference Programs.Scheduled for November 8-12 in National Harbor, MD, the event will take place at the Gaylord National Hotel & Convention Center.
Annual Program Oversight Committee
The SITC 2017 Annual Meeting & Pre-Conference Programs website is now live! Click here to visit the website to learn the latest information on this event, including details on registration, housing, abstract submission and more.
Click here to view an archived listing of previous Annual Meeting websites.
This may be due to an alternate immune checkpoint, CD200 (OX2) checkpoint blockade. The immuneosuppressive CD200 protein shuts down the immune system through multiple mechanisms (Xiong et al, 2016). We demonstrated that human glioblastoma in the top ...
While I agree with Stephanie's detailed account, simply put checkpoint molecules are a signature of exhausted/ chronically stimulated lymphocytes and therefore serves as a feedback mechanism to mitigate the immune activation from entering an overdrive ...
Hi Stephanie many thanks for your ample reply. It makes sense indeed in order to secure self-antigens. However, is immune system evasion by means of immune checkpoint a matter of quality or quantity? I mean is there a cutoff for "normal"CTLA4, PD1 levels ...
The expression and regulation of immune checkpoints is an area of active investigation. In answer to your question regarding whether healthy tissues express immune checkpoint inhibitors in the steady state they absolutely do! Immune ...
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