If you would like to place an ad on this page for a job opening you have at your organization, please download the agreement form (.DOC – .PDF) for the posting criteria and submit it, along with the job description, to email@example.com.
If you have any questions, please contact SITC at firstname.lastname@example.org or call 414-271-2456.
The National Cancer Institute (NCI) is seeking candidates with a medical degree and experience in cancer immunotherapy for the position of Supervisory Physician (GP-602-15), Branch Chief of the Immuno-Oncology Branch (IOB), Developmental Therapeutics Program (DTP), Division of Cancer Treatment and Diagnosis (DCTD).
The candidate will serve as a Supervisory Physician/Branch Chief directing the activities of the IOB (https://dtp.cancer.gov/organization/iob/default.htm) and will collaborate with investigators of the DTP (https://dtp.cancer.gov/). The candidate will manage and coordinate all functions of the branch including planning, designing and executing preclinical research and clinical development of immunotherapy agents through a cross-functional collaboration within DTP and DCTD. As a senior advisor to the Division Director and Institute Director, the candidate will set priorities for federal investment in the development of new methods, technologies, and treatment paradigms that integrate immunomodulation strategies into clinical studies. The candidate is expected to manage and coordinate a program that includes grants and contracts to discover, investigate, develop and bring to initial clinical trials novel immuno-oncology products.
A vacancy announcement to fill the position is posted on www.usajobs.gov. To apply, please visit: https://www.usajobs.gov and search NIH-SR-DH-18-10270590.
This is a full-time government position. Compensation for this position is commensurate with the individual’s qualifications and experience as permitted within Federal government appointments. Individuals who apply must be U.S. citizens.
DHHS, NIH and NCI are Equal Opportunity Employers.
The EACRI, a division of the Providence Cancer Institute, at the Robert W. Franz Cancer Center invites applicants for full-time faculty positions in Immuno-oncology. The rank is open and will depend on the candidate’s research accomplishments. We are seeking energetic, creative and innovative individuals to complement a strong team of cancer immunologists. Applicants must hold a PhD and/or MD degree in immunology or related discipline. Applicants can be an established investigator with a strong record of published research in immunology and demonstrated success in garnering external funding or a junior faculty candidate with a clear vision of how to establish a funded, productive research laboratory. Competitive start-up funding is available. Additional information on our Institute can be found at www.franzcancer.org.
Apply now by sending your curriculum vitae, a one page description of current and future research interests, and names and contact information of three references to email@example.com.
The Markowitz lab is seeking a Postdoc Fellow or Research Scientist whose skills and personal and professional experience have prepared them to contribute to our commitment to diversity and excellence.
The lab’s research interest is in studying immune suppressor cells, their role in the development of melanoma, and means of inhibiting their actions. We are also developing tools to predict which patients are likely to fail immune-based therapy via novel high dimensional flow cytometric, mass spectrometry and informatics techniques, allowing those patients to be treated with other potentially more effective therapies. We are a translational laboratory striving to translate the knowledge gained in the laboratory via immune-based and traditional biochemical approaches to the clinic. https://moffitt.org/providers/joseph-markowitz/
The postdoctoral fellow/research scientist is a non-tenure track researcher who assumes the direct responsibility of conducting and performing experiments or directly overseeing experimentation as part of a research team under the general guidance of Dr. Markowitz.
Develop biomarkers for immune-based therapy.
Study resistance mechanisms to immune checkpoint blockade.
The Ideal Candidate:
proficiency in flow cytometry, IHC, immunoblot, cell culture techniques, general immunology
comfortable with murine experiments,
general proficiency in computers, general familiarity with bioinformatics and statistics preferred.
Manage projects under general supervision.
General laboratory techniques such as flow cytometry, murine experiments, informatics (assistance will be given with coding, but need to understand the basics to apply it and make small changes), immunohistochemistry, immunoblots, cell culture, ELISA, proliferation assays, immunoprecipiation
Technical writing of research papers and assistance with grants.
Credentials and Qualifications:
M.D. or Ph.D. in Immunology, Bioinformatics, Cancer Biology
Research Scientist required having a minimum of 3 years as a Postdoc Fellow.
A competitive salary and benefits package will be offered to the successful candidate.
Moffitt is located in Tampa, Florida, which is a thriving city with a low cost of living, excellent culture and outstanding restaurants, and a high quality of life. This position requires someone who can appreciate the sunshine, the nation’s top beaches, and year-round golf, biking, boating, fishing, tennis, swimming, snorkeling and other recreational activities that are associated with the Gulf Coast of Florida.
To formally apply: visit https://moffitt.org/careers-education/. Interested applicants should attach a single PDF file that includes a current CV and cover letter expressing interest with this position to either the Postdoc req 27406 or Research Scientist Req 27435.
AbbVie Stemcentrx is currently offering a unique opportunity for a highly motivated individual to join our team as a Director, Companion Diagnostics Pathology. The Companion Diagnostics Pathology Group resides within the Companion Diagnostics Center of Excellence (CDx COE), which supports CDx development across Abbvie. The successful candidate will provide leadership and expertise in human disease pathology and molecular pathology to support the clinical development of tissue-based companion diagnostics for oncology drug candidates. As a member of the development project teams he/she will have the opportunity to work in a highly collaborative environment and to support projects throughout clinical development.
Key Responsibilities Includes:
* Lead the identification and development of tissue-based biomarkers, including their characterization and validation (biomarker prevalence, clinical utility for patient selection/stratification, relevant cutoffs, etc.) and the proposed pathology assays (specificity and sensitivity, scoring system, etc.)
* Design, implement and oversee pathology based biomarker and diagnostic testing and data analysis for clinical development studies:
o Direct the development, outsourcing and validation of clinically applicable tissue based assays. Assists in the development of assay protocols as needed.
o Write the relevant pathology based biomarker and diagnostics testing sections in drug development and registration documents such as clinical study protocols, clinical study reports, investigator brochures, and regulatory submission packages (INDs, NDA’s,BLA's).
* Provide pathology input to development project teams and ensure access to state of the art tissue based techniques and samples for target pathway evaluation in human disease:
o Implement technologies and/or methodologies as needed, via a combination of in-house efforts and the use of CROs or other external expertise using techniques such as in situ hybridization, immunohistochemistry, IHC multiplexing, fluorescence applications, use of image analysis algorithms, laser capture microdissection, RNAseq, qPCR, etc.
o Evaluate the scientific basis and clinical applicability of the proposed assays, their validation status and any related technical issues.
o Assume responsibility for the assessment and scoring of specimens and the preparation of reports summarizing the data, analysis and interpretation of findings.
o Collaborate with project teams from concept to reagent generation to quantitation and approval plan for CDx as needed.
* Participate in the evaluation of external licensing or collaborative opportunities (including CDx collaborations), and oversee internal components of shared programs.
* Lead and participate in project development teams or sub-teams as needed. Coordinate with appropriate team members to advance projects efficiently.
* Highly experienced pathologist (MD, PhD, or DVM degree) with 8+ years of relevant post-doctoral academic, clinical and/or industry pathology experience. Board certification in the United States is desirable but not required.
* In depth experience with the discovery, characterization, clinical validation and utilization of tissue based biomarkers and potential diagnostics:
o Awareness of the challenges of implementing tissue based biomarker and diagnostic technologies in the clinical setting
o Direct experience in development, outsourcing and validation of clinically applicable tissue based biomarker assays
* A proven Molecular Pathology track record with credible publications and Pathology support for research and clinical science:
o Demonstrated expertise in tissue-based analysis such as in situ hybridization, immunohistochemistry, fluorescence applications, laser capture microdissection
o Expertise with human diseases and evaluation of disease pathogenesis with tools such as experimental mouse models
o Expertise with image analysis software and algorithm design
* Demonstrated excellence in independently leading and conducting research and ability to summarize information/data in a concise, easy to understand manner
* Excellent leadership skills including mentoring, motivation and delegation
* Excellent verbal and written communication and presentation skills in English
* High level of initiative and ability to work independently
* High level of business awareness
Equal Opportunity Employer Minorities/Women/Veterans/Disabled
URL for your website or original job posting:
Job Contact Information: firstname.lastname@example.org, Tim Silcott, 650-296-4528
About USUHS: The mission of the USUHS is to educate, train, and comprehensively prepare uniformed services health professionals, scientists, and leaders to support the Military and Public Health Systems, the National Security and National Defense Strategies of the United States, and the readiness of our Uniformed Services. USUHS is integral part of F. Edward Hébert School of Medicine. Within campus, we collaborated with Armed Forces Radiobiology Research Institute and with Murtha Cancer Center, Walter Reed, capital Breast care project. USUHS is located in close proximity to National Institute of health, providing opportunities for cross campus collaboration. More info: https://www.usuhs.edu/
Core facilities at USUHS: https://www.usuhs.edu/research/core-facilities
About Geeta Upadhyay: Dr. Upadhyay recently joined USUHS faculty as tenure track faculty. Dr. Upadhyay received her training at Harvard, NCI, UTHSCSA, Georgetown University. Her research is focused on biomarker discover, drug development and drug resistance in breast cancer.
Click here for a complete list of publications.
PROJECT DESCRIPTION: The postdoctoral candidate will have the opportunity to conduct some of the research described in our newly funded R01 grant title “Role of Ly6K in TGF-beta and immune escape pathways of triple negative breast cancer”. Ly6K, a GPI anchored protein, is expressed in cancer tissue and is required for in vivo tumor progression. We have shown that Ly6K activates TGF-beta signaling, epithelial-to-mesenchymal transition and PD-L1 expression. We found that knockdown or pharmacological inhibition of Ly6K by small molecules binders, can significantly inhibit multiple distinct aspects of the biological activity of Ly6K. This proposal will be focused on determining the molecular basis of Ly6K action and Ly6K targeted therapeutics.
Flow cytometry: Sample prep, execution on the machine, data analysis, sorting and multicolor panel
Cell culture: Primary and cell lines, T cell expansion.
In vivo studies: Mouse handling, i.p. injections, tumor injections and
measurements, immunotherapy assays, tissue collection and processing, mouse genetics.
In vitro and ex vivo assays: cell signaling, live cell imaging, westerns, qRT-PCR, luminex.
Upadhyay G, Yin Y, Yuan H, Li X, Derynck R, Glazer RI. Stem cell antigen-1 enhances tumorigenicity by disruption of growth differentiation factor-10 (GDF10)-dependent TGF-beta signaling. Proc. Natl. Acad. Sci. U.S.A., 108, 7820–7825 (2011). PMID: 21518866.
AlHossiny M, Luo L, Frazier WR, Steiner N, Gusev Y, Kallakury B, Glasgow E, Creswell K, Madhavan S, Kumar R, Upadhyay G. Lymphocyte antigens 6 complex K/E-transforming growth factor-beta axis promotes breast cancer tumorigenesis. Cancer Res., 76, 3376–3386 (2016). PMID: 27197181.
Luo L, McGarvey P, Madhavan S, Kumar R, Gusev Y, Upadhyay G. Lymphocyte antigens 6 complex gene family members drive tumorigenesis. Oncotarget, 7, 11165–11193 (2016). PMID: 26862846
Click here to apply for the postdoctoral position at USUHS website.
Heal the sick, Advance the science, Share the knowledge.
The successful candidate will be an immunologist with expertise in senescent remodeling of the immune system with aging and will lead an independent and nationally and internationally-recognized research program. This person will hold academic rank at Mayo Clinic commensurate with experience and qualifications. The ideal candidate will target the profound changes that occur in the immune system with age and how such changes can be linked with the progression of a variety of chronic illnesses and increased risk of acute infections, using cutting edge technologies. Specific areas of interest may include effects of age on micro- environmental niches supporting adaptive immune cell development, cell intrinsic physiologic changes in long-lived adaptive immune cells, age-related extrinsic stresses impacting immune cells and the aging of the innate immune system. Faculty will be expected to work collaboratively with colleagues and to be an active participant in the enterprise-wide Department of Immunology and the Robert and Arlene Kogod Center on Aging. The individual may also align with other Mayo Clinic centers such as cancer, transplant, cardiovascular diseases, biomedical discovery, individualized medicine and regenerative medicine.
QUALIFICATIONS: Credentials of a successful candidate will include a doctoral degree (PhD, MD/PhD, MD or equivalent) in a biomedical science field and rigorous postdoctoral training. Junior investigators should have a strong publication record; evidence of successful competition for external funding is preferred. Mid-career investigators must have a strong publication record and history of NIH- or equivalent extramural funding.
MAYO CLINIC is an integrated, multidisciplinary academic medical center with comprehensive programs in medical education and research that span across three group practice and research sites. We support a vibrant and diverse research enterprise, with programs in basic, translational, clinical, and population sciences. Mayo has world-class faculty, laboratories, and state-of-the-art core facilities and biorepositories. The Mayo Clinic Graduate School of Biomedical Sciences trains and supports PhD and MD/PhD students.
We offer a highly competitive compensation package with sustained salary support, capital equipment funding, technical and computational resources, and exceptional benefits. Mayo Foundation is an affirmative action and equal opportunity educator and employer that values and promotes diversity as a strategic advantage.
Mayo Clinic's campuses in Arizona are located in Phoenix and Scottsdale, in the beautiful Sonoran Desert. With Phoenix being the sixth largest city in the nation, this sunny "desert metropolis" offers the amenities of a big city in the midst of a strikingly beautiful, rugged, southwest landscape.
Scottsdale frequently earns praise as a highly desirable place to live. The city's more than 200,000 residents enjoy a vibrant mix of culinary hot spots, arts and entertainment, professional and collegiate sports teams, and community resources. The region's desert climate promotes an outdoor lifestyle with a full complement of sports and recreation.
CLICK HERE to learn more and apply!
Applications should include a cover letter, CV and a statement of research interests. Specific questions should be directed to:
Dr. Sandra Gendler, Ph.D. Department of Immunology Chair, Search Committee C/O Adriana Semko email@example.com.
©2018 Mayo Foundation for Medical Education and Research. Post offer/pre-employment drug screening is required. Mayo Clinic is an equal opportunity educator and employer (including veterans and persons with disabilities).
Oncology is a key therapeutic area for AbbVie, with a portfolio consisting of three marketed products — Imbruvica®, Venclexta™, and Empliciti™ — and a pipeline containing multiple promising new molecules that are being studied in nearly 200 clinical trials in 19 different types of cancer.
AbbVie is expanding its oncology hub on the West Coast, with three sites in the San Francisco Bay Area (Redwood City, South San Francisco, and Sunnyvale) focused on the discovery and development of novel oncology therapies. More than 1,000 AbbVie scientists, clinicians, and product developers with strong entrepreneurial roots work across these three sites. They combine their expertise in immuno-oncology, stem cells, and cell-signaling with their knowledge of bispecific antibodies, antibody-drug conjugates (ADCs), and covalent-inhibitor technologies to discover and develop novel cancer treatments. This position will be based at Stemcentrx, AbbVie's South San Francisco, CA location.
As part of a talented and multi-disciplinary team advancing an exciting novel approach to drug development, the successful candidate will lead method validation and transfer activities associated with QC testing of the Company’s GMP products.
The successful candidate will be responsible for providing strategic leadership and technical expertise overseeing in-house validation and method transfer activities as the company progresses through clinical trials. This is a hands-on role that requires close collaboration with Quality Control, Analytical Development, Research, Manufacturing, Quality Assurance and Regulatory groups.
Primary Duties and Responsibilities:
* Coordinate/collaborate with the Analytical Development and Research Bioassay teams to define methods required for the control system for release and stability testing of monoclonal antibody intermediates, antibody-drug conjugate drug substances and drug products
* Coordinate/collaborate on method optimization and transfer from the Analytical Development and Research Bioassay Teams to Quality Control
* Oversee determination of appropriate system suitability criteria based on data trending
* Establish appropriate timelines for QC validation activities
* Establish validation strategies that are phase appropriate and drive validation strategy and execution to meet required timeline
* Prepare and provide technical review of relevant documentation including test methods, transfer documentation, validation protocols, reports and raw data
* Approve final test methods after validation in alignment with control strategy as well as after any revisions
* Serve as a technical advisor to the critical reagent control and monitoring program
* Collaborate on the development of specifications for intermediates, drug substances, drug products and reference standards
* Assist in the preparation of CMC regulatory submissions
* Implement new technology and instrumentation into QC lab to maintain state-of-the-art control systems
* Provide technical expertise necessary for troubleshooting instrumentation, investigating unexpected results/deviations, optimizing QC methods and developing appropriate CAPAs
Required Skills and Specifications:
* In-depth knowledge of analytical methods used for monoclonal antibodies and antibody-drug conjugates (Bioassay experience a plus)
* Experience with optimizing assays for a QC environment, including defining appropriate system suitability
* Demonstrated track record of leadership in method validation activities, including development of supporting documentation and managing timelines
* Experience managing method transfers
* Experience with LIMs systems and electronic document management and quality management systems a plus
* In-depth experience with regulatory/pharmacopeia requirements for biologic product testing and validation
* In-depth knowledge of FDA, EMA, GMP, WHO and ICH regulatory requirements
* Excellent interpersonal skills, organizational skills and communication skills including the proven ability to manage direct reports and influence collaborators in other departments
* Excellent verbal and written communication skills
* Ability to operate in a fast-paced, multi-disciplinary industrial environment
* A minimum BS, but preferably an MS or Ph.D in Biological Sciences, Biochemistry or Chemistry
* Minimum of 8+ years of experience in the biotechnology or pharma industry with experience in biologics
To apply for this position, click here: https://ars2.equest.com/?response_id=9e0e64055b0ca77acbb0cc287ba2d1a4
We are looking to hire post-doctoral scientists in the fields of tumor immunology and cancer immunotherapy. The positions are available in the laboratory of Dr. Samir N. Khleif at the Lombardi Comprehensive Cancer Center (LCCC), Georgetown University Medical Center in Washington DC. The major focus of the lab is the basic and translational research that is dedicated to understanding the cellular/molecular mechanisms underlying immune cell activation, localization and immunosuppression within the tumor microenvironment. Another major focus of the lab is to decipher the mechanisms leading to resistance to cancer immunotherapy.
The ideal candidates will hold a PhD/MD in Immunology, Cancer Biology, Cell Biology or Molecular Biology. A deep and thorough understanding of the T cell biology, various immune mechanisms is mandatory for this application. In addition, for one of the positions knowledge of mouse models of obesity is required. Experience in the area of in vivo cancer biology is a plus. The required skills include but are not limited to: mouse models, immunohistochemistry, flow cytometry, in vitro assays.
Candidates must be proficient in oral and written English, excellent communication, and multi-tasking skills, and be team-oriented, proactive and results driven. Candidates are invited to apply for competitive fellowships during their stay in the lab.
The positions can start between July-August, at the earliest. The starting date can be flexible. Interested candidates should send their resume, containing a list of publications, a summary of past research, contact information of 2 or 3 referees, and a motivation letter in a single.pdf file to firstname.lastname@example.org or email@example.com.
About the Lab
The Khleif Laboratory offers a highly competitive, stimulating and dynamic working environment within an exceptional scientific setting in an international, young, enthusiastic, motivated team. The laboratory is working on high-impact projects and conducts research that can be translated into the clinical practice. The laboratory is part of the LCCC, a multidisciplinary research center focusing on cancer, genetics, metabolism and immune-therapy. LCCC offers many core facilities including: Imaging, Molecular Biology, Metabolomics, Histology and animal facility, etc. Technical support is granted within the lab. Remuneration is competitive. Georgetown University is an equal opportunity employer and all eligible candidates irrespective of their social background are welcome to apply.
Job Type: Full-time
Oncology is a key therapeutic area for AbbVie, with a portfolio consisting of three marketed products — Imbruvica, Venclexta, and Empliciti — and a pipeline containing multiple promising new molecules that are being studied in nearly 200 clinical trials in 19 different types of cancer.
AbbVie is expanding its oncology efforts with a focus on the discovery and development of novel oncology therapies. More than 1,000 AbbVie scientists, clinicians, and product developers with strong entrepreneurial roots work across these multiple sites. They combine their expertise in immuno-oncology, stem cells, and cell-signaling with their knowledge of bispecific antibodies, antibody-drug conjugates (ADCs), and covalent-inhibitor technologies to discover and develop novel cancer treatments. This position is located at the AbbVie site in Redwood City, CA.
Director, Immuno-Oncology Clinical Biomarkers
We are searching for a Director of Immuno-Oncology Clinical Biomarkers (I-O CB) to join Oncology Early Development (OED). This is a unique opportunity to lead a team of scientists that drive the strategy and implementation of the clinical biomarker plans across innovative first in-class, cutting edge programs, in the area of Immuno-Oncology.
In this role, you will report directly to the Group Project Leader in Oncology Early Development (OED) and will join an experienced team with a strong track record in developing biotech products. As the Director of I-O CB, you will lead a team of clinical biomarker scientists that participate in cross-functional OED teams. The scope of OED is clinical candidate nomination through the end of clinical proof of concept. As a Director of I-O CB, you will be responsible for the development and execution of comprehensive biomarker plans that will enable science based decision making on the clinical programs. You will liaise with Project Director, Medical Director, preclinical biomarker leads, discovery leads, and experts in pharmacokinetics/pharmacodynamics (PK/PD) to develop and implement the clinical biomarker strategies for OED stage I-O assets. You will also help guide IND enabling preclinical biomarker studies, help draft and review regulatory documents (such as INDs),
Investigator Brochures and clinical protocols, design clinical biomarker studies for OED stage compounds. To be successful in this role, you need a deep understanding of cancer immunotherapy and related development, and convincingly articulate the rationale for the biomarker plans to senior management and governance committees within AbbVie. You will be a clinical scientific leader of I-O CB within the organization.
Key goals include:
The Developmental Therapeutics Program (DTP), of the NCI, is seeking candidates with an advanced degree in Biology, Microbiology, or equivalent for the position of Branch Chief, Biological Resources Branch (BRB).
The candidate will be a Supervisory Biologist directing the activities of the BRB (https://ncifrederick.cancer.gov/research/brb/) and will collaborate with investigators of the NCI DTP (https://dtp.cancer.gov/). The candidate will manage and coordinate all functional requirements for the branch including preclinical development research, clinical manufacturing and testing of biopharmaceutical products, and related studies pertaining to the extramural work of the BRB. The agents to be developed and manufactured in this program are biopharmaceutical and immunotherapy agents including, but not limited to, recombinant proteins, peptides, vaccines, monoclonal antibodies, genetically modified viruses, bacteria or mammalian cells, immunomodulating agents, cytokines and growth factors, tumor antigens, and nanotechnology-based biopharmaceutical products. The Chief manages and coordinates a system of grants and contracts to discover, investigate, develop and bring to initial clinical trials selected biologics and biopharmaceuticals with the intent of producing a therapeutic affect that alters the biology of cell growth and metastasis.
This is an exploratory ad to gauge interest and a possible candidate pool. A vacancy announcement (VA) to fill the position will be posted on WWW.USAJOBS.GOV at a later date.
Candidates must be U.S. citizens. Compensation for this position is commensurate with the individual’s qualifications and experience as permitted within Federal Government appointments.
Please submit your C.V., a statement of interest, and contact information for three references to Dr. Rosemarie Aurigemma, Developmental Therapeutics Program, National Cancer Institute at firstname.lastname@example.org (phone 240-276-5465).
DHHS, NIH, and NCI are Equal Opportunity Employers.
The Developmental Therapeutics Program (DTP), of the NCI, is seeking candidates with an advanced degree in Toxicology, Pharmacology, or equivalent for the position of Branch Chief, Toxicology and Pharmacology Branch (TPB).
The candidate will be a Supervisory Toxicologist directing the activities of the TPB (https://dtp.cancer.gov/organization/tpb/) and will collaborate with investigators of the NCI DTP (https://dtp.cancer.gov/). The candidate will manage and coordinate all functional requirements for the branch including formulation of research and/or testing the biological, toxicological, carcinogenic potential of chemicals, and/or biopharmaceutical agents and make recommendations for the development of new or revised programs to meet existing needs in the areas of toxicology, pharmacology, and pharmacodynamics.
The candidate initiates and develops research projects investigating mechanisms underlying the toxicity of chemicals, classes of chemicals, or other agents or important topics related to cancer therapeutics research. Candidates with interest in developing model systems for predicting and measuring toxicological and pharmacological properties of anticancer agents are of particular interest.
Please submit your C.V., a statement of interest. and contact information for three references to Dr. Rosemarie Aurigemma, Developmental Therapeutics Program, National Cancer Institute at email@example.com (phone 240-276-5465).
The Department of Laboratory Medicine at Memorial Sloan Kettering Cancer Center, New York seeks a Clinical Laboratory Immunologist. The Memorial Hospital for Cancer and Allied Diseases is a worldwide leader in cancer treatment and diagnosis, consistently voted as one of the best specialty hospitals in the nation. The Department of Laboratory Medicine provides diagnostic testing for all patients seen at Memorial Sloan Kettering Cancer Center (MSKCC). The Department is comprised of the following services: Clinical Chemistry, including Point-of Care, Hematology, including Coagulation and Cellular Immunology, Microbiology, Cellular Therapy, Transfusion Medicine, including blood bank, donor room and apheresis, and jointly with the Pathology Department, Hematopathology. The main campus operation is comprised of seven laboratories and the highest-volume hospital-based blood donor room in the City of New York. In addition, there are six regional sites located in New Jersey, Westchester, Long Island and several outpatient sites in Manhattan that collect specimens and perform limited testing on site.
The Cellular Immunology Laboratory performs over 35 thousand tests annually and is a highly advanced laboratory with a staff of 15 technologists, a supervisor, manager, and one Medical Service Chief. The environment provides substantial opportunities for clinical/translational research, as well as collaboration with investigators throughout MSKCC. The successful candidate will have the opportunity to participate in an expanding program focused on service, research and teaching. Several programs at Memorial Hospital are currently expanding resulting in increased tests volumes. The Department of Laboratory Medicine is concurrently expanding to support these new and expanding hospital programs that include a new, state-of-the art Lab Medicine building with dedicated laboratory space for individual areas.
Candidates must have an MD and/or PhD with expertise in cellular immunology including flow cytometry and functional/cytotoxic assays, particularly as they apply to the analysis of hematopoietic stem cell transplantation, immune reconstitution and immune modulation. Candidates must also have expertise in innate and humoral immunity, particularly related to clinical test utilization and assay development. Board Certification from the American Board of Clinical Laboratory Immunology is preferred and Board Certification from the American Board of Histocompatibility and Immunogenetics would be a plus. An additional requirement is the ability to obtain a NYS DOH COQ covering the relevant categories.
Applicants should send CV and cover letter describing personal area(s) of interest and long-term career goals to:
Melissa S Pessin, MD PhDChair, Department of Laboratory MedicineMemorial Sloan Kettering Cancer CenterCenter for Laboratory Medicine327 East 64th Street, Fifth Floor, Room 542New York, NY 10065email: firstname.lastname@example.org
Postdoctoral Associate Position in Tumor Immunology/Immunotherapy at the Duke Cancer Institute.
The Hanks Lab is a basic/translational research lab in the Duke Cancer Institute with an interest in understanding cancer immune evasion and immunotherapy resistance. We are seeking a motivated, hardworking Post-Doctoral Candidate with a background in immunology to take a leadership role in projects focused on understanding the role of the tumor microenvironment on immunotherapy resistance. This will be a two-year minimum position. The candidate will be expected to work independently but capable of collaborating with other lab members in a team-oriented work environment. Recent Ph.D. graduates preferred. http://www.thehankslab.com
Interested candidates should send CVs to Dr. Brent A. Hanks at email@example.com for consideration. Select candidates will undergo a phone interview and finalists will be interviewed in-person at Duke University.
Oncology is a key therapeutic area for AbbVie, with a portfolio consisting of three marketed products — Imbruvica, Venclexta, and Empliciti — and a pipeline containing multiple promising new molecules that are being studied in nearly 200 clinical trials in 19 different types of cancer. AbbVie is expanding its oncology organization focusing on the discovery and development of novel oncology therapies. More than 1,000 AbbVie scientists, clinicians, and product developers with strong entrepreneurial roots combine their expertise in immuno-oncology, stem cells, apoptosis and cell-signaling with their knowledge of bispecific antibodies, antibody-drug conjugates (ADCs), and covalent-inhibitor technologies to discover and develop novel cancer treatments.
The Translational Modeling & Simulation department within the Drug Metabolism and Pharmacokinetics (DMPK) group is searching for a DMPK project representative in South San Francisco to provide project support enabling biologics progression (incl. antibody-drug conjugates (ADCs) and bi-specifics) in Oncology discovery and clinical development. The scientist will collaborate closely with Discovery project teams; developing and executing the DMPK and PKPD strategies necessary to facilitate the advancement of optimized candidate molecules.
The Haura lab has an opening for a postdoctoral scholar in tumor immunology research. We pursue an interdisciplinary approach spanning immune biology and proteogenomics to characterize tumor immune states and response to immune therapy. We are looking for a highly motivated and independent postdoctoral research fellow who is interested in working on a project related to tumor neoantigens that predict response to tumor infiltrating lymphocytes and PD1 checkpoint therapy in lung cancer patients.
This individual will design, conduct and interpret correlative experiments using human samples from accruing immunotherapy clinical trials, in particular a trial using adoptive cell transfer of tumor infiltrating lymphocytes (TIL). This individual will identify and validate predicted neoantigens from lung cancer immunotherapy trials using novel functional assays. The candidate will have immediate access to rich array of patient samples including frozen tumor and tumor cell suspensions, and apheresis products and will join a productive, energetic team of immunologists, bioinformaticians, clinicians, surgeons, and protein researchers within our group.
Successful candidates will have a publication track record demonstrating a strong background in in tumor immunology and/or immune-therapy; with an interest in translational research. Prior experience is required with some of the following techniques: high-throughput screening, mammalian cell culture, cell transfection assays, flow cytometry (FACS). Expertise in molecular biology (cloning, plasmid purification), and extraction of nucleic acids and protein from patient tissue samples is highly preferred. Candidates with experience in validating neoantigens in model systems will be given priority.u
Candidates with experience in cell culture, gene manipulation in cancer cells, cloning, T-cell activation assays or other immune cell based assays, and DNA/RNA/protein isolation techniques will be given preference.
M.D. or PhD in Molecular Biology, Immunology, Biochemistry, or relevant field.
Interested applicants should send their current CV with recent publications and contact information for three references to Dr. Eric Haura at Eric.Haura@moffitt.org
Moffitt Cancer Center is a premier cancer research institution in the United States. Built in an attractive location, it is the only NCI-designated cancer center in Florida and one of the top institutions in systems medicine and personalized cancer therapy. Moffitt features a number of high-quality core facilities equipped with state-of-the-art instrumentation and a cluster of expertise particularly in adoptive cell therapies.
The Neuro-Oncology Branch (NOB), Center for Cancer Research (CCR) of the National Cancer Institute (NCI), National Institutes of Health (NIH), Department of Health and Human Services (HHS), Bethesda, MD, is actively recruiting for a tenure-track principal investigator to work in the area of immunology and/or immunotherapy. The NOB Immunology/Immunotherapy Investigator will be tasked with forming and leading an independent research program. This position will build the basic immunology program in the NOB and complement ongoing and planned translational research and clinical trials evaluating the effects of immunotherapy in patients with primary brain tumors. This program will be able to access biospecimens generated from ongoing and planned immunotherapy protocols within the NOB, thus creating an opportunity to perform correlative studies to interrogate the complex biology of immunologic response, toxicity, and treatment resistance. Demonstrated expertise in scientific inquiries in immunotherapy and/or immunology are essential, but prior work in brain tumors is not required. This is an exciting opportunity to join a growing trans-institutional research team that promotes and supports collaborations across the basic, translational, and clinical research spectrum to develop novel therapeutics for individuals with primary central nervous system malignancies that will globally influence the field.
About NCI's Center for Cancer Research
The CCR is an intramural research component of the NCI. The CCR’s enabling infrastructure facilitates clinical studies at the NIH Clinical Center, the world’s largest dedicated clinical research complex; and provides extensive opportunities for collaboration with other investigators at the forefront of medical research. This environment enables scientists and clinicians to undertake high-risk, high-impact, laboratory- and clinic-based investigations. Investigators are supported by a wide array of intellectual, technological, and research resources. This includes surgical and pathology facilities; animal facilities; and dedicated, high-quality technology cores. For an overview of CCR, please visit: http://ccr.cancer.gov/. Access to core research support is also available to NCI CCR investigators through the Office of Science and Technology Resources (OSTR) that identifies, evaluates, and makes available new technologies and scientific resources. For more information of OSTR, please visit: https://ostr.cancer.gov/resources. The NCI Center of Excellence in Immunology (CEI) also provides a network of diverse intellectual, financial, and physical resources to help develop new initiatives, projects, and collaborations. For more information of CEI, please visit: https://ccrod.cancer.gov/confluence/display/COEI/Home.
The NOB also offers collaborative opportunities and resources through its various laboratory programs, encompassing areas of research in cell biology, genomics, and metabolomics, as well as its pre-clinical translational research program. For more information of NOB, please visit: https://ccr.cancer.gov/Neuro-Oncology-Branch.
The successful candidate should have a Ph.D. or equivalent doctoral degree and a well-established track record of publications in the area of immunology/immunotherapy. Candidates will be evaluated on their educational background, scholarly work, leadership and mentoring activities, and experience with immunology/immunotherapy research. Salary is commensurate with education and experience. Candidates may be U.S. citizens, U.S. permanent residents, or eligible for a visa that will enable work in the U.S.
Please submit curriculum vitae and statement of research interests and future plans to: http://irp-positions.nih.gov/job/NOBImmunology. Review of applications will begin on or about July 1, 2018 and the position will remain open until filled.
HHS, NIH, and NCI are Equal Opportunity Employers.
The NIH and NCI are dedicated to building a diverse community in its training and employment programs and encourages the application and nomination of qualified women, minorities, and individuals with disabilities.
Gene Therapies Branch and Cell Therapies Branch in Division of Cellular and Gene Therapies (DCGT), Office of Tissues and Advanced Therapies, Food and Drug Administration are recruiting full-time review scientists. Successful candidates will perform scientific review, interpretation, and documentation of product manufacturing data to evaluate the safety and quality of gene and/or cell therapy products in regulatory submissions to FDA. Candidates are expected to be proficient in applying relevant scientific knowledge and research experience to support multi-disciplinary scientific and regulatory reviews of regulatory submissions. Successful candidates may also have opportunities to contribute to guidance and policy development activities relevant to gene and/or cell therapy.
DCGT is strongly committed to bringing FDA and other scientists, patient advocates, and the public together in partnership to develop new therapies for the 21st Century, while protecting human subjects and ensuring product safety. The candidate will be a part of a cutting-edge and fast-paced scientific and regulatory environment.
These positions will be filled through FDA's Service Fellowship program. The appointment is for up to four years with opportunities for renewal. Applications will be accepted from U.S. citizens or Lawful Permanent Residents (green card holders) only. No previous Federal experience is required. Appointment does not confer any entitlement to a position in the competitive service, and there is no entitlement to Merit Systems Protection Board (MSPB) appeals rights.
QUALIFICATIONS: Ph.D. or equivalent advanced degree in the areas specified below. Postdoctoral experience highly preferred. In addition, you must have strong collaborative skills, excellent written and oral communication skills, and evidence of leadership potential. Knowledge of federal regulations applicable to drugs, biologics, and devices is helpful but not a requirement for consideration.
SALARY: Salary commensurate with education/experience.
LOCATION: FDA White Oak campus, Silver Spring, Maryland, U.S.A.
HOW TO APPLY: Submit a statement of interest for a gene therapy or cell therapy review scientist position, resume or curriculum vitae (CV) detailing relevant experience, transcripts, names/contact information for three references, proof of U.S. citizenship or lawful permanent residency status, and other supporting documentations to Ms. Teslyn Hudgins at firstname.lastname@example.org. Applications will be accepted through August 27, 2018. However, candidates will be considered as received. For best consideration, please submit your application as soon as possible.
Tel: +1 414 271 2456 | Fax: +1 414 276 3349 | Email: email@example.com