The Society for Immunotherapy of Cancer (SITC) hosted Session 203 during the 38th Annual Meeting & Pre-Conference Programs on Saturday, November 4, 2023. Available here are the presentation slides and video from “Session 203: Stromal Cells and TLS” as permitted by presenters.
Nikhil Joshi, PhD – Yale School of Medicine
Ellen Puré, PhD – Perelman School of Medicine at the University of Pennsylvania
Solid tumors are complex neo-organs comprised of many cell types and a dynamic extracellular matrix. In recent years, there has been increasing focus on the importance of interactions between immune and stromal cells and on understanding how these interactions facilitate and regulate immune responses. Organization is key to immune responses, but the details of how immune cells are organized in the TME is an emerging area. The stromal microenvironment of human cancer is heterogeneous, but in some cases highly organized tertiary lymphoid structures (TLS) exist in association with tumors, which can exhibit cardinal features of lymph nodes. This session will review the importance of organization in facilitating immune responses and highlight developments in our understanding of TLS biology in cancer and the role of TLS in IO responses.
To view the entire program schedule (including presenter permission to post) please click here.
SITC 2023 Annual Meeting: Saturday, November 401:59:02