SITC Archive Library

The Society for Immunotherapy of Cancer (SITC) hosted the "Workshop on Intratumoral Immunomodulation" during the SITC 2019 Annual Meeting on November 7, 2019. Available here are the presentation slides and video from "Session 5: Systemic Combinations."

Program Summary

Immunotherapy treatments inherently rely on the presence of immune cells, both systemic and localized to the tumor microenvironment. Immunologically “hot” tumors, such as melanoma, have demonstrated enhanced responses to immunotherapy treatments; however, many tumors are “cold”, lacking the necessary immune components for a successful treatment. Many techniques, including radiotherapy, synthetic immunomodulators, oncolytic viruses, and certain systemic treatments, have been shown to manipulate the immune status of the treated tumor microenvironment, and even those tumor sites elsewhere in the body (abscopal effects). Such manipulations can increase the presence of desirable immune infiltrates and potentially lead to favorable treatment outcomes. In this workshop, the current status of intratumoral immunomodulation was presented and future directions for the field discussed, along with their implications for current and forthcoming immunotherapy treatments.

Program Organizers

• Nina Bhardwaj, MD, PhD – The Tisch Cancer Institute at The Icahn School of Medicine at Mount Sinai
• Adi Diab, MD – The University of Texas MD Anderson Cancer Center

To view the entire program schedule (including presenter permission to post) please click here.