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Basal cell carcinoma: PD-L1/PD-1 checkpoint expression and tumor regression after PD-1 blockade

03-29-2017 09:28

Published in the Journal for ImmunoTherapy of Cancer (JITC), this article shows the findings of an investigation of the expression of PD-L1 and its association with PD-1 expression in the basal cell carcinoma tumor microenvironment and presents the first report of an objective anti-tumor response to pembrolizumab (anti-PD-1) in a patient with metastatic PD-L1 (+) basal cell carcinoma, whose disease had previously progressed through hedgehog pathway-directed therapy.

Authors: Evan J. LipsonEmail author, Mohammed T. Lilo, Aleksandra Ogurtsova, Jessica Esandrio, Haiying Xu, Patricia Brothers, Megan Schollenberger, William H. Sharfman and Janis M. Taube
JITC (2017) 5:23

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